ARPC2
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Official Full Name
actin related protein 2/3 complex, subunit 2, 34kDa -
Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. -
Synonyms
ARPC2;actin related protein 2/3 complex, subunit 2, 34kDa;actin related protein 2/3 complex, subunit 2 (34 kD);actin-related protein 2/3 complex subunit 2;ARC34;p34 Arc;arp2/3 complex 34 kDa subunit;ARP2/3 protein complex subunit 34;PRO2446;p34-Arc;PNAS-139
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Rhesus macaque
- Porcine
- Mouse
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- Brain
- In Vitro Cell Free System
- Human Cells
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ARPC2 involved in several pathways and played different roles in them. We selected most pathways ARPC2 participated on our site, such as Axon guidance,B Cell Receptor Signaling Pathway,Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | MED18,FGF20A,SCN3B,COL4A3,FGFR1B,PEA15A,SDCBP,CDH4,SIAH2,KDR |
| Endocytosis | TRAF6,CHMP2A,PSD3,SNF8,WASLB,SNX4,RAB11FIP1,PLD1,TFR1A,ARF3A |
| CDC42 signaling events | CFL1,CDC42BPA,PAK4,ARPC4,TNK2,BAIAP2,ARPC1B,CTNNA1,ARPC3,IQGAP3 |
| EPH-Ephrin signaling | EFNA5,EPHB4A,EFNB3B,ARPC1B,CLTB,ARHGEF28,AP2A2,EFNA3B,AP2M1,EPHA2 |
| Axon guidance | MYL12A,EPHA10,EPHA2,SPNA1,EGF,NEFLB,ROCK1,SEMA3B,EFNB1,KDR |
| EPHB-mediated forward signaling | EFNB3B,EPHB4B,KALRN,ARPC4,ACTR3,ITSN1,ARPC5,KALRNB,CFL1,ARPC1B |
| B Cell Receptor Signaling Pathway | MAP2K2,CDK7,PLEKHA2,PDPK1A,PIK3CD,VAV2,MAPK1,CDK4,PIK3AP1,HRAS |
| Bacterial invasion of epithelial cells | SEPT6,ELMO2,SHC4,PIK3CD,ITGB1,PIK3R3,PIK3CG,CDH1,CDC42,SEPT3 |
Protein Function
ARPC2 has several biochemical functions, for example, AP-1 adaptor complex binding,Arp2/3 complex binding,contributes_to actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC2 itself. We selected most functions ARPC2 had, and list some proteins which have the same functions with ARPC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinesin binding | SERPINB1A,FAM83D,KCNC1,KIF18B,KIFAP3A,SYBU,CD36,NUP62,NEK6,PLEKHM2 |
| contributes_to actin filament binding | ARPC1B,ARPC4,MYH9,ARPC3,MYH10,ACTR2,ACTR3,ARPC5 |
| protein binding | AAAS,SRP14,MRPL11,ZFP346,CASP1,NOP58,SULT1A2,ARMCX1,ORC3L,GLS |
| structural constituent of cytoskeleton | DES,KRT17,SORBS3,EPB42,TUBB1,BFSP2,TUBE1,TUBA3D,TUBA8L3,NGS |
| AP-1 adaptor complex binding | AP1AR,RAB38,RAB32 |
| Arp2/3 complex binding | HAND2,GMFG,WHAMM,GMFB,SNX9,PICK1,CORO1B |
Interacting Protein
ARPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC2.
CORO1B;VCL;VCL;HLA-B;Wasf1;ACTR3B;TRAF6;q7ard3_yerpe;tdh;MYH9;IQGAP1;CAPZA2;Tpm1;Actb;ACTR2;PPP1CB
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