Active Recombinant Rat RAB5A, Member RAS Oncogene Family

• Cat.No.: Rab5a-1115R

Specification

• Cat. No.: Rab5a-1115R
• Description: Rab5A is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. The small Rab5A GTPase is localized to plasma membrane, clathrin coated vesicles, caveosomes and early endosomes. Rab5 is a key regulator of the early endocytic pathway and plays a role in early endosome fusion and caveolar vesicle targeting to early endosomes. Furtermore it is also implicated in EGF receptor activation and apoptotic cell engulfment.
• Source: E. coli.
• Usage: For in vitro use only.
• Form: Liquid. Supplied in 50 mM Tris-HCl pH 8.0, 100 mM NaCl, 10 mM MgCl2, 10 μM GDP and 2 mM mercaptoethanol.
• Activity: 100 pmol of protein can bind > 80 pmol of GDP.
• Purity: ≥ 90% by SDS-PAGE.
• Storage: Quality guaranteed for 12 months. Store at -80℃. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: Rab5a RAB5A, member RAS oncogene family [ Rattus norvegicus ]
• Synonyms: Rab5a; RAB5A, member RAS oncogene family
• Gene ID: 64633
• mRNA Refseq: NM_022692
• Protein Refseq: NP_073183
• UniProt ID: O88565
• Chromosome Location: 9q11
• Pathway: Endocytosis; Amyotrophic lateral sclerosis (ALS)
• Function: GTP binding; GTPase activity; nucleotide binding; protein binding; GDP-dissociation inhibitor binding; guanyl nucleotide binding