"Rab5a" Related Products

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Recombinant Rat RAB5A, Member RAS Oncogene Family

Cat. No. : Rab5a-1115R
Description : Rab5A is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. The small Rab5A GTPase is localized to plasma membrane, clathrin coated vesicles, caveosomes and early endosomes. Rab5 is a key regulator of the early endocytic pathway and plays a role in early endosome fusion and caveolar vesicle targeting to early endosomes. Furtermore it is also implicated in EGF receptor activation and apoptotic cell engulfment.
Source : E. coli.
Usage : For in vitro use only.
Form : Liquid. Supplied in 50 mM Tris-HCl pH 8.0, 100 mM NaCl, 10 mM MgCl2, 10 μM GDP and 2 mM mercaptoethanol.
Activity : 100 pmol of protein can bind > 80 pmol of GDP.
Purity : ≥ 90% by SDS-PAGE.
Storage : Quality guaranteed for 12 months. Store at -80℃. Avoid freeze / thaw cycles.
Gene Name : Rab5a RAB5A, member RAS oncogene family [ Rattus norvegicus ]
Synonyms : Rab5a; RAB5A, member RAS oncogene family
Gene ID : 64633
mRNA Refseq : NM_022692
Protein Refseq : NP_073183
UniProt ID : O88565
Chromosome Location : 9q11
Pathway : Endocytosis; Amyotrophic lateral sclerosis (ALS)
Function : GTP binding; GTPase activity; nucleotide binding; protein binding; GDP-dissociation inhibitor binding; guanyl nucleotide binding

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