RAB8A
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Official Full Name
RAB8A, member RAS oncogene family
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Overview
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an;average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of;proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51%;similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding;sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that;of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS;superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated;as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable.;This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. -
Synonyms
RAB8A; RAB8A, member RAS oncogene family; MEL, mel transforming oncogene (derived from cell line NK14); ras-related protein Rab-8A; RAB8; oncogene c-mel; ras-associated protein RAB8; mel transforming oncogene (RAB8 homolog); mel transforming oncogene (de;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- 6×His
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
RAB8A involved in several pathways and played different roles in them. We selected most pathways RAB8A participated on our site, such as Endocytosis, AMPK signaling pathway, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ACAP1;RAB11FIP4A;PARD6A;GRK5;ARF3A;ACAP3;VPS37D;WIPF2B;WASB |
| AMPK signaling pathway | SCD5;MAP3K7;AKT1S1;IRS2;PRKAB1;CREB3L4;PPARGC1A;Scd1;PPP2R2D |
| Pancreatic secretion | ATP2B4;ATP2A2;RAP1B;CLCA5;RAB27B;CTRB1;CELA3B;PNLIPRP2;PLA2G2F |
RAB8A has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB8A itself. We selected most functions RAB8A had, and list some proteins which have the same functions with RAB8A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GDP binding | RAB21;RAB35;RAB18;RAB3B;RAB10;RAB12;RRAS;EIF2B1;RAB8B |
| GTP binding | RAB34A;NME1;RAP2A;RAN;RALBB;ARL17B;RASL10B;NUDT2;GTPBP5 |
| GTPase activity | EEFSEC;GNAT2;RAB14L;SAR1B;RAB2B;GNA11B;GNL1;TUBB6;RAB3AB |
| Rab GTPase binding | RIN3;ATP6AP1;SYTL3;RAB11FIP3;EVI5;EVI5L;ANXA2;GOLGA5;NSF |
| myosin V binding | RAB10;FUS;RAB39B;RAB3B;RAB27B;RAB11A;RAB6B;RAB8A;RAB27A |
| protein binding | YIPF2;CEP152;NITR9;EHD1;HSPA1L;LSM8;PSMC5;HJURP;PREP |
| protein kinase binding | PPP1R12B;CD8A;USP37;GOLGA2;CCNK;CDK5RAP2;EEF2;MLKL;CAMK2N2 |
RAB8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB8A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB8A.
OCRL; OPTN; gdp
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