| Official Full Name | RAB7A, member RAS oncogene family |
| Background | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.;Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family;member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded;protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly;conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. |
| Synonyms | RAB7A; RAB7A, member RAS oncogene family; RAB7, RAB7, member RAS oncogene family; ras-related protein Rab-7a; Ras-associated protein RAB7; RAB7, member RAS oncogene family; RAB7; PRO2706; FLJ20819 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
rab7a involved in several pathways and played different roles in them. We selected most pathways rab7a participated on our site, such as Endocytosis, Phagosome, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with rab7a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PIP5K1BA; SNX1B; TSG101A; WASH; MET; ARPC5; CHMP5B; RAB10; HLA-C; ARPC5LA |
| Phagosome | ITGB3B; CANX; ATP6V1C1B; HLA-DPA1; HLA-DOB; FCGR1; CTSSA; BLB1; HGS; SEC61AL2 |
| Salmonella infection | MAPK9; RAB7; IL8L1; MAPK12B; ROCK1; CASPA; RAB7B; CXCL3; RAC1; NFKB1 |
| Amoebiasis | LAMA2; C9; COL4A4; PLCB1; MUC2; IL12A; RAB5B; IL10; COL5A1; PRKACA |
| Tuberculosis | Il23a; Il12b; PPP3R1; MAPK10; FCER1G; CASP10; IFNA2; FCGR2B; IFNA8; HSPA9; HLA-DRB4 |
rab7a has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by rab7a itself. We selected most functions rab7a had, and list some proteins which have the same functions with rab7a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GDP binding | RAB3B; RAB35; RAB28; RAB31; PCK1; RAB7L1; RAB14; RAB40C; RAB8B; RAN |
| GTP binding | REM1; RRAGCB; RAB4A; TUBA8; RAB1; RHOF; HHAT; RND3; RAB37; TUBA1B |
| GTPase activity | IIGP1; GNAO1; DNM2; RASEF; RAB3C; RAB3AA; GNL1; GNA14; GNG5; DIRAS1 |
| Rac GTPase binding | PKN1; SRGAP1; NOXA1; PAK6; RAB7A; CORO1C; ARFIP2; CAV1; PAK1; RCC2 |
| protein binding | KIAA1217; FLOT1; CD40; AGXT2L2; IL12A; PIR; SGCA; WWOX; BRAT1; KTN1 |
rab7a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rab7a here. Most of them are supplied by our site. Hope this information will be useful for your research of rab7a.
RILP; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; DNM2; SH3KBP1; EIF1B; MCC; MPG; HLA-B; VHL; GABARAPL2; IKBKE; ATG5; PRKAB1; TRAF6
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