RAB7A
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Official Full Name
RAB7A, member RAS oncogene family
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Overview
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.;Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family;member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded;protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly;conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. -
Synonyms
RAB7A; RAB7A, member RAS oncogene family; RAB7, RAB7, member RAS oncogene family; ras-related protein Rab-7a; Ras-associated protein RAB7; RAB7, member RAS oncogene family; RAB7; PRO2706; FLJ20819;
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- His
- His (Fc)
- Avi
- His|GST
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- Involved Pathway
- Protein Function
- Interacting Protein
- RAB7A Related Articles
- RAB7A Related Research Area
RAB7A involved in several pathways and played different roles in them. We selected most pathways RAB7A participated on our site, such as Endocytosis, Phagosome, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | KIF5C;PRKCI;SMAD3A;BIN1B;EHD4;EEA1;CHMP5;TGFB1;FMNL3 |
Phagosome | ITGB3B;H2-AB1;ATP6V1H;TUBB2;HLA-DQA2;C3A.3;TUBA8;HLA-DRB5;ATP6V0A1B |
Salmonella infection | FLNB;KLC4;WASB;CCL4;MAPK8A;IL8L2;KLC1B;CXCL1;CXCL8B.3 |
Amoebiasis | PRKACA;SERPINB1A;SERPINB2;NFKB1;C9;LAMC2;ITGB2L;PIK3CD;RAB5C |
Tuberculosis | CALM4;PPP3CC;HLA-DRB5;HLA-DPB1;IL12A;IL1A;NOS2;FCGR1;TLR4 |
RAB7A has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB7A itself. We selected most functions RAB7A had, and list some proteins which have the same functions with RAB7A. You can find most of the proteins on our site.
Function | Related Protein |
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GDP binding | ARL3;RAP1B;TRIM23;RAB18;SRP54A;ARL2;RHOB;RAB28;RAB7 |
GTP binding | RAB32A;CDC42;GIMAP2;RHOGD;RAB44;RAB27B;ARF3B;RAB28;SAR1A |
GTPase activity | TUBB4A;EFTUD2;TUBB2B;RAB36;RAB22A;GBP6;RAB18B;SAR1B;RAB1 |
Rac GTPase binding | ARHGAP4A;CAV1;SRGAP2;RALBP1;NOX1;CDKL5;PAK6;FMNL1;RAB7 |
protein binding | CCAR1;PRKDC;PEBP1;ABL2;GUCY1B3;COMP;LAGE3;HGD;RBM6 |
RAB7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB7A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB7A.
RILP; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; DNM2; SH3KBP1; EIF1B; MCC; MPG; HLA-B; VHL; GABARAPL2; IKBKE; ATG5; PRKAB1; TRAF6
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Q&As (7)
Ask a questionRAB7A activity is regulated by several signaling pathways. One important pathway involves the phosphorylation of RAB7A by protein kinases, such as LRRK2 and CDK1, which modulate its GTPase activity and subcellular localization. Additionally, RAB7A can be regulated by post-translational modifications, including ubiquitination and acetylation. These modifications can affect its interaction with effector proteins and its ability to regulate vesicle trafficking and autophagy.
Targeting RAB7A for therapeutic purposes faces several challenges. One challenge is the need for selective modulation of RAB7A activity without affecting other closely related RAB GTPases. Additionally, the development of efficient delivery systems to specifically target RAB7A in affected cells or tissues is essential. Furthermore, understanding the precise spatiotemporal regulation of RAB7A and its interactions with effector proteins is crucial for designing effective therapeutic interventions. Overcoming these challenges will be instrumental in harnessing the therapeutic potential of targeting RAB7A in neurodegenerative diseases.
argeting RAB7A could be a promising therapeutic strategy for neurodegenerative diseases. One approach is to modulate RAB7A activity using small molecules or gene therapy to restore its normal function in vesicle trafficking and autophagy. Another strategy is to identify compounds that enhance the clearance of aggregated proteins through the autophagy-lysosome pathway, where RAB7A plays a crucial role. Further research is needed to develop and optimize these therapeutic interventions.
RAB7A interacts with various effector proteins to exert its functions in intracellular trafficking. For example, it binds to RILP (RAB7A-interacting lysosomal protein) to recruit dynein-dynactin motor complexes, facilitating the movement of late endosomes towards microtubule minus ends. RAB7A also interacts with FYCO1 and PLEKHM1, which are involved in autophagosomal maturation and fusion with lysosomes. These interactions enable RAB7A to coordinate and regulate vesicle trafficking processes.
RAB7A dysfunction has been implicated in various neurodegenerative diseases. For example, mutations in the RAB7A gene have been associated with Charcot-Marie-Tooth disease type 2B and amyotrophic lateral sclerosis. In these diseases, impaired RAB7A function disrupts the transport of essential cargoes, such as neurotrophic factors and lysosomal enzymes, leading to neuronal degeneration and dysfunction. Understanding the precise mechanisms by which RAB7A contributes to these diseases is an active area of research.
RAB7A is a small GTPase protein that plays a crucial role in regulating late endocytic trafficking. It controls the maturation of late endosomes to lysosomes by mediating the fusion of these compartments. Additionally, RAB7A is involved in autophagy, a process that degrades damaged organelles and protein aggregates. It promotes the formation of autophagosomes and their fusion with lysosomes. RAB7A also regulates the transport of cargo along the endocytic pathway.
RAB7A is involved in the regulation of lysosomal biogenesis. It promotes the transport of lysosomal enzymes from the trans-Golgi network to late endosomes/lysosomes. RAB7A also regulates the fusion of late endosomes with lysosomes, allowing the delivery of newly synthesized lysosomal proteins. Moreover, RAB7A interacts with transcription factors, such as TFEB and MITF, to regulate the expression of lysosomal genes, thereby influencing lysosomal biogenesis and function.
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