rab7a Protein, RAB7A, member RAS oncogene family


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Official Full Name RAB7A, member RAS oncogene family
Background RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.;Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family;member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded;protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly;conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
Synonyms RAB7A; RAB7A, member RAS oncogene family; RAB7, RAB7, member RAS oncogene family; ras-related protein Rab-7a; Ras-associated protein RAB7; RAB7, member RAS oncogene family; RAB7; PRO2706; FLJ20819
    • Species :
    • Dog
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RAB7A-194H Recombinant Human RAB7A, His-tagged E.coli His
    Human RAB7A-2583HCL Recombinant Human RAB7A 293 Cell Lysate HEK293 N/A
    Rat Rab7a-1129R Recombinant Rat Rab7a Protein, His-tagged E.coli His
    Rat RAB7A-4898R Recombinant Rat RAB7A Protein Mammalian Cell His
    Dog RAB7A-1117D Recombinant Dog RAB7A, Member RAS Oncogene Family E.coli N/A
    Dog RAB7A-1118D Recombinant Dog RAB7A, Member RAS Oncogene Family, GST-His E.coli His/GST

    rab7a involved in several pathways and played different roles in them. We selected most pathways rab7a participated on our site, such as Endocytosis, Phagosome, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with rab7a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis PIP5K1BA; SNX1B; TSG101A; WASH; MET; ARPC5; CHMP5B; RAB10; HLA-C; ARPC5LA
    Salmonella infection MAPK9; RAB7; IL8L1; MAPK12B; ROCK1; CASPA; RAB7B; CXCL3; RAC1; NFKB1
    Amoebiasis LAMA2; C9; COL4A4; PLCB1; MUC2; IL12A; RAB5B; IL10; COL5A1; PRKACA
    Tuberculosis Il23a; Il12b; PPP3R1; MAPK10; FCER1G; CASP10; IFNA2; FCGR2B; IFNA8; HSPA9; HLA-DRB4

    rab7a has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by rab7a itself. We selected most functions rab7a had, and list some proteins which have the same functions with rab7a. You can find most of the proteins on our site.

    Function Related Protein
    GDP binding RAB3B; RAB35; RAB28; RAB31; PCK1; RAB7L1; RAB14; RAB40C; RAB8B; RAN
    GTPase activity IIGP1; GNAO1; DNM2; RASEF; RAB3C; RAB3AA; GNL1; GNA14; GNG5; DIRAS1
    Rac GTPase binding PKN1; SRGAP1; NOXA1; PAK6; RAB7A; CORO1C; ARFIP2; CAV1; PAK1; RCC2
    protein binding KIAA1217; FLOT1; CD40; AGXT2L2; IL12A; PIR; SGCA; WWOX; BRAT1; KTN1

    rab7a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rab7a here. Most of them are supplied by our site. Hope this information will be useful for your research of rab7a.

    RILP; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; DNM2; SH3KBP1; EIF1B; MCC; MPG; HLA-B; VHL; GABARAPL2; IKBKE; ATG5; PRKAB1; TRAF6

    Day, PM; Thompson, CD; et al. Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection. JOURNAL OF VIROLOGY 87:3862-3870(2013).
    Osinska, M; Wiejak, J; et al. Distinct expression, localization and function of two Rab7 proteins encoded by paralogous genes in a free-living model eukaryote. ACTA BIOCHIMICA POLONICA 58:597-607(2011).

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