|Official Full Name||RAB7B, member RAS oncogene family|
|Background||Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.|
|Synonyms||RAB7B; RAB7B, member RAS oncogene family; ras-related protein Rab-7b; MGC9726; MGC16212; Ras related protein Rab 7b; RAB7; Ras-related protein Rab-7|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
rab7b involved in several pathways and played different roles in them. We selected most pathways rab7b participated on our site, such as Phagosome, Salmonella infection, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with rab7b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Phagosome||BMA1; ATP6V1C1; TFRC; RILP; SEC22BB; FCGR1; HLA-DMB; MHC2A; ATP6V1E2; FCGR2B|
|Salmonella infection||CCL3L1; IL-8; IFNGR2; CXCL1; KLC2; MAPK14A; KLC1A; RHOGB; CXCL2; CDC42L|
|Amoebiasis||PLCB4; IL12B; ACTN2; IL1R2; ACTN1; PTK2; SERPINB4; SERPINB6B; LAMA3; LAMC2|
rab7b has several biochemical functions, for example, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by rab7b itself. We selected most functions rab7b had, and list some proteins which have the same functions with rab7b. You can find most of the proteins on our site.
|GTP binding||RHOJ; GNAI2; GTPBP1L; RAB18; RAB18B; GIMAP6; REM2; ARF6; FPGT; GNAT1|
rab7b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rab7b here. Most of them are supplied by our site. Hope this information will be useful for your research of rab7b.