Recombinant Human MAGEA4, His-tagged

• Cat.No.: MAGEA4-28847TH
• Product Overview: Recombinant full length Human MAGEA4 with a N terminal 20 amino acid His tag, 337 amino acids with a predicted MWt 37kDa inclusive of tag. UniID = P43358

Specification

• Description: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.
• Protein length: 317 amino acids
• Conjugation: HIS
• Molecular Weight: 37.000kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:20% Glycerol, 0.32% Tris HCl
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT LEEVPAAESA GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP DAESLFREAL SNKVDELAHF LLRKYRAKEL VTKAEMLERV IKNYKRCFPV IFGKASESLK MIFGIDVKEV DPTSNTYTLV TCLGLSYDGL LGNNQIFPKT GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY GEPRKLLTQD WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI AYPSLREAAL LEEEEGV.
• Sequence Similarities: Contains 1 MAGE domain.

Gene Information

• Gene Name: MAGEA4 melanoma antigen family A, 4 [ Homo sapiens ]
• Official Symbol: MAGEA4
• Synonyms: MAGEA4; melanoma antigen family A, 4; MAGE4; melanoma-associated antigen 4; cancer/testis antigen family 1; member 4; CT1.4; MAGE 41; MAGE X2; MAGE4A; MAGE4B; melanoma associated antigen 4; MGC21336
• Gene ID: 4103
• mRNA Refseq: NM_001011548
• Protein Refseq: NP_001011548
• MIM: 300175
• Uniprot ID: P43358
• Chromosome Location: Xq28
• Function: molecular_function; protein binding