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MAGEA2

Official Full Name

melanoma antigen family A, 2
Overview

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
Synonyms

MAGEA2; melanoma antigen family A, 2; MAGE2; melanoma-associated antigen 2; cancer/testis antigen family 1; member 2; CT1.2; MAGEA2A; MAGE-2 antigen; melanoma antigen 2; cancer/testis antigen 1.2; cancer/testis antigen family 1, member 2; MAGEA2B; MGC1319;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAGEA2-691H	Recombinant Human MAGEA2, His-tagged	E.coli	His	1-169aa	$319 / 25ug
Human	MAGEA2-4555HCL	Recombinant Human MAGEA2 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MAGEA2 involved in several pathways and played different roles in them. We selected most pathways MAGEA2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MAGEA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MAGEA2 has several biochemical functions, for example, histone deacetylase binding, protein binding, repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAGEA2 itself. We selected most functions MAGEA2 had, and list some proteins which have the same functions with MAGEA2. You can find most of the proteins on our site.

Function	Related Protein
histone deacetylase binding	BRMS1L;CCND1;SRF;PRDM1;ZNHIT1;HDAC3;KPNA2;YWHAB;MAGEA2B
protein binding	G3BP1;MIS18BP1;ILF2;TSSK1;NRP1B;CRHBP;RG9MTD1;DFFA;YWHAE
repressing transcription factor binding	MAGEA2B;DDX20;HDAC9;TBP;SRI;TLE4;MYC;CTBP1;HMGB1
ubiquitin protein ligase binding	SCAMP3;GRIK2;SMAD5;ANAPC2;BID;FANCL;RIPK1;UBXN6;UQCRC1

MAGEA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGEA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGEA2.

TP53; TRIM28; HDAC3; UBE2H; ubiq_human; UBA1