Recombinant Human SIRT5

• Cat.No.: SIRT5-31167TH
• Product Overview: Recombinant full length Human SIRT5 protein with N-terminal proprietary tag, 60 kDa.

Specification

• Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.
• Source: E. coli
• Tissue specificity: Widely expressed.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.

Gene Information

• Gene Name: SIRT5 sirtuin 5 [ Homo sapiens ]
• Official Symbol: SIRT5
• Synonyms: SIRT5; sirtuin 5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5; NAD-dependent deacetylase sirtuin-5
• Gene ID: 23408
• mRNA Refseq: NM_001193267
• Protein Refseq: NP_001180196
• MIM: 604483
• Uniprot ID: Q9NXA8
• Chromosome Location: 6p23
• Pathway: Signaling events mediated by HDAC Class I, organism-specific biosystem
• Function: NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; hydrolase activity; metal ion binding; zinc ion binding