sirt2
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  • Official Full Name
  • sirtuin 2
  • Background
  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
  • Synonyms
  • SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; NAD-dependent protein deacetylase sirtuin-2; sirtuin-2; sirtuin type 2; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; regulatory protein SIR2 homolog 2; NAD-dependent deacetylase sirtuin-2;
Cat.#:SIRT2-174HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT2 protein, T7/His-tagged
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Cat.#:SIRT2-191HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human SIRT2 Protein, His-tagged
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Cat.#:SIRT2-2680HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT2, His-tagged
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Cat.#:SIRT2-30564THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT2
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Cat.#:SIRT2-30566THTag:HIS
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SIRT2, His-tagged
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Cat.#:SIRT2-30567THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT2, His-tagged
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Cat.#:SIRT2-31405THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT2, His-tagged
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Cat.#:SIRT2-463HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT2, His-tagged
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Cat.#:SIRT2-4875HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sirtuin 2, His-tagged
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Cat.#:SIRT2-4876HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sirtuin 2, GST-tagged
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Cat.#:SIRT2-647HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT2 Protein, His-tagged
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Cat.#:SIRT2-929HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT2, His-tagged
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Cat.#:SIRT2-15152MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SIRT2 Protein
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Cat.#:Sirt2-648MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sirt2 Protein, His-tagged
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Cat.#:SIRT2-5408RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SIRT2 Protein
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Cat.#:Sirt2-649RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sirt2 Protein, His-tagged
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Cat.#:SIRT2-2178CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIRT2
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Cat.#:SIRT2-9999ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SIRT2
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Cat.#:SIRT2-1834HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SIRT2 293 Cell Lysate
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Cat.#:Kit-1083Tag:
Source (Host):Species:
Product nameSIRT2 Inhibitor Screening Assay Kit (Fluorometric)
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Cat.#:Kit-2026Tag:
Source (Host):Species:
Product nameSIRT2 Direct Fluorescent Screening Assay Kit
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Involved Pathway

SIRT2 involved in several pathways and played different roles in them. We selected most pathways SIRT2 participated on our site, such as Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class III, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling events mediated by HDAC Class I
PRMT5; WDR77; SIRT7; MXD1; SIRT2; NR2C1; TFCP2; FKBP3; GATA1; SIRT5
Signaling events mediated by HDAC Class III
SIRT2; SIRT7

Protein Function

SIRT2 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding, NAD-dependent histone deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT2 itself. We selected most functions SIRT2 had, and list some proteins which have the same functions with SIRT2. You can find most of the proteins on our site.
Function
Related Protein
Function NOT NAD+ ADP-ribosyltransferase activity
Related Protein SIRT5; SIRT1; SIRT2; SIRT3
Function NAD+ binding
Related Protein SIRT5; UXS1; SIRT3; SIRT1; HADH; ALDH1A3; HPGD; SIRT7; SIRT4; SIRT2
Function NAD-dependent histone deacetylase activity
Related Protein SIRT1; SIRT6; SIRT2
Function NOT NAD-dependent histone deacetylase activity
Related Protein SIRT2
Function NAD-dependent histone deacetylase activity (H4-K16 specific)
Related Protein SIRT2
Function NAD-dependent protein deacetylase activity
Related Protein SIRT2; SIRT1
Function beta-tubulin binding
Related Protein SERPINB1A; SPAST; MAP1S; EMD; RGS2; PIFO; HTT; TRPV4; SIRT2; HDAC6
Function chromatin binding
Related Protein ATAD2; TFAM; TOP1; TFAP2A; SIN3A; CHAF1A; CENPB; TRIM24; MORF4L1; NR5A1B
Function histone acetyltransferase binding
Related Protein EID1; MYOCD; SIRT2; MEF2A; CREB1; CITED2; MTF1; EGR1; CEBPB; TAF7L
Function histone deacetylase activity
Related Protein HDAC10; HDAC9; SIRT2; HDAC8; SIRT1; HDAC11; HDAC5; HDAC3; HDAC9B; HDAC1
Function histone deacetylase binding
Related Protein YY1; TCF21; TFAP4; NACC2; MEF2D; CRY1; TRAF6; RBBP4; SRF; SP2
Function protein binding
Related Protein C8orf74; PLG; TMEM231; CSNK1E; EFCAB4B; UNC13A; VMP1; HK1; DEFA6; EXO1
Function protein deacetylase activity
Related Protein HDAC4; SIN3A; HDAC3; HDAC5; SIRT2; HDAC10; HDAC2; HDAC1; SIRT1; HDAC9
Function transcription factor binding
Related Protein YWHAZ; NFATC4; KAT8; UBN1; HEY2; WWP2; FOXA3; MSX2; SIX2; HES3
Function tubulin deacetylase activity
Related Protein HDAC6; SIRT2
Function NOT tubulin deacetylase activity
Related Protein SIRT2
Function ubiquitin binding
Related Protein FAM125A; TOP2A; DNAJC2; OTUB1A; FAN1; PER2; IDE; NEDD4; UBXN11; SMAD3
Function zinc ion binding
Related Protein MARCH8; LHX8A; SIAH1; RASSF1; ING2; FBXO40.1; LIN28B; CRIP2; TRIP6; RNF145B

Interacting Protein

SIRT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT2.
BUB1B; KAT2B; RELA; CDC14B; G6PD; RIPK3; MYOD1; HDAC6

SIRT2 Related Articles

Yeung, F; Ramsey, CS; et al. Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases. ONCOGENE 34:798-804(2015).
Bajpe, PK; Prahallad, A; et al. A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. ONCOGENE 34:531-536(2015).