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Official Full Name sirtuin 3
Background This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Synonyms SIRT3; sirtuin 3; SIR2L3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; sir2-like 3; sirtuin type 3; SIR2-like protein 3; regulatory protein SIR2 homolog 3; NAD-dependent deacetylase sirtuin-3, mitochondrial; silent mating type information regulation 2, S.cerevisiae, homolog 3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIRT3-10H Recombinant Human SIRT3 protein, His-tagged E.coli His
    Human SIRT3-1832HCL Recombinant Human SIRT3 293 Cell Lysate HEK293 N/A
    Human SIRT3-1833HCL Recombinant Human SIRT3 293 Cell Lysate HEK293 N/A
    Human SIRT3-2681H Recombinant Human SIRT3, GST-tagged E.coli GST
    Human SIRT3-2747H Recombinant Human Sirtuin 3, His-tagged E.coli His
    Human SIRT3-28H Recombinant Human SIRT3 Protein, His-tagged E.coli His
    Human SIRT3-30594TH Recombinant Human SIRT3, His-tagged E.coli His
    Human SIRT3-341H Recombinant Human SIRT3 E.coli N/A
    Human SIRT3-345H Recombinant Human SIRT3, His-tagged E.coli His
    Human SIRT3-346H Recombinant Human SIRT3, His-tagged E.coli His
    Human SIRT3-347H Recombinant Human SIRT3, GST-tagged E.coli GST
    Human SIRT3-4877H Recombinant Human Sirtuin 3, GST-tagged Sf9 Insect Cell GST
    Human SIRT3-4878H Recombinant Human Sirtuin 3, GST-tagged E.coli GST
    Human SIRT3-699H Recombinant Human SIRT3 Mammalian Cell His
    Mouse Sirt3-1375M Recombinant Mouse Sirt3 protein, His-tagged E.coli His
    Rat Sirt3-1376R Recombinant Rat Sirt3 protein, His-tagged E.coli His
    Chicken SIRT3-4341C Recombinant Chicken SIRT3 Mammalian Cell His
    Zebrafish SIRT3-5033Z Recombinant Zebrafish SIRT3 Mammalian Cell His

    sirt3 involved in several pathways and played different roles in them. We selected most pathways sirt3 participated on our site, such as Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with sirt3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Central carbon metabolism in cancer SLC2A2; PIK3R5; AKT1; SCO2; PDGFRA; FGFR3; ERBB2; PDGFRB; FLT3; GLS

    sirt3 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by sirt3 itself. We selected most functions sirt3 had, and list some proteins which have the same functions with sirt3. You can find most of the proteins on our site.

    Function Related Protein
    NOT NAD+ ADP-ribosyltransferase activity SIRT2; SIRT3; SIRT5; SIRT1
    enzyme binding CNTNAP2; PTEN; HIF1A; Alb; DAOA; SLPI; UGT1A2; AKIRIN2; PTPLAD2; TSPAN15
    hydrolase activity FURINA; DESI1; USPL1; PSMA6A; Ces2e; DNASE1L3L; UFSP2; SGPP2; PPP4CA; REXO4
    protein binding NR2F1; PFDN5; JAM3B; LASP1; RPL14; LGI4; SPCS1; TRAPPC2; CEBPG; ZNF436
    zinc ion binding RXRG; ZMAT2; ZRANB3; LIMCH1B; MT1G; TXNDC17; ALAD; DEF8; ADH1A; APOBEC2A

    sirt3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sirt3 here. Most of them are supplied by our site. Hope this information will be useful for your research of sirt3.

    SKP2; OPA1; ATP5A1; DLAT; Ppif; b3kms0_human; FOXO3; UGDH; SBF1; HERC2; ALDH2; ATP5B; UQCRH

    Auburger, G; Gispert, S; et al. Mitochondrial Acetylation and Genetic Models of Parkinson's Disease. MITOCHONDRION IN AGING AND DISEASE 127:155-182(2014).
    Nguyen, TTM; Wong, R; et al. Cyclophilin D Modulates Mitochondrial Acetylome. CIRCULATION RESEARCH 113:1308-+(2013).

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