sirt7
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  • Official Full Name
  • sirtuin 7
  • Background
  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
  • Synonyms
  • SIRT7; sirtuin 7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7; NAD-dependent deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7
Cat.#:SIRT7-12HTag:Flag
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT7, Flag-tagged
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Cat.#:SIRT7-30848THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT7, T7 -tagged
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Cat.#:SIRT7-30867THTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SIRT7, His-tagged
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Cat.#:SIRT7-4884HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sirtuin 7, His-tagged
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Cat.#:SIRT7-585HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT7, His-tagged
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Cat.#:SIRT7-15157MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SIRT7 Protein
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Cat.#:Sirt7-1383RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sirt7 protein, His-tagged
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Cat.#:SIRT7-5410RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SIRT7 Protein
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Cat.#:SIRT7-4207RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SIRT7 Protein, His-tagged
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Cat.#:SIRT7-5512CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIRT7
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Cat.#:SIRT7-1828HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SIRT7 293 Cell Lysate
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Involved Pathway

SIRT7 involved in several pathways and played different roles in them. We selected most pathways SIRT7 participated on our site, such as Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class III, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling events mediated by HDAC Class I
GATA2; PRMT5; GATA1; SIRT2; SIRT5; SIRT7; SIRT4; TFCP2; MXD1; WDR77
Signaling events mediated by HDAC Class III
SIRT2; SIRT7

Protein Function

SIRT7 has several biochemical functions, for example, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K18 specific), chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT7 itself. We selected most functions SIRT7 had, and list some proteins which have the same functions with SIRT7. You can find most of the proteins on our site.
Function
Related Protein
Function NAD+ binding
Related Protein SIRT4; SIRT7; UXS1; HADH; GLUD1; SIRT2; SIRT6; SIRT3; HPGD; SIRT1
Function NAD-dependent histone deacetylase activity (H3-K18 specific)
Related Protein SIRT7
Function chromatin binding
Related Protein AAAS; POLG; ELK1; DNMT3B; NFKB2; AIRE; ERG; ASF1A; SUZ12; HIF1AB
Function metal ion binding
Related Protein ENTPD8; ZNF285A; EBF4; ADAP1; ECE2; CYP4T8; ZNF202; ZFPM2A; SORBS2; LRRK1
Function protein binding
Related Protein PRLR; KCND2; KRAS; TRIM16; SNX33; TRAF4; GPRASP1; HYI; PPP1R2P9; S100A10

Interacting Protein

SIRT7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT7.
MAGED1; CBX1

SIRT7 Related Articles

Kiran, S; Chatterjee, N; et al. Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal. FEBS JOURNAL 280:3451-3466(2013).