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Official Full Name sirtuin 7
Background This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Synonyms SIRT7; sirtuin 7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7; NAD-dependent deacetylase sirtuin-7; sirtuin type 7; SIR2-like protein 7
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • His
    • Myc/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIRT7-120H Recombinant Human SIRT7 Protein, His-tagged E. coli His
    Human SIRT7-12H Recombinant Human SIRT7, Flag-tagged E.coli Flag
    Human SIRT7-1828HCL Recombinant Human SIRT7 293 Cell Lysate HEK293 N/A
    Human SIRT7-21H Recombinant Human SIRT7 Protein, His-tagged E.coli His
    Human SIRT7-30848TH Recombinant Human SIRT7, T7 -tagged E.coli T7
    Human SIRT7-30867TH Recombinant Human SIRT7, His-tagged Sf9 Insect Cell His
    Human SIRT7-4884H Recombinant Human Sirtuin 7, His-tagged Sf9 Insect Cell His
    Human SIRT7-585H Recombinant Human SIRT7, His-tagged E.coli His
    Mouse SIRT7-15157M Recombinant Mouse SIRT7 Protein Mammalian Cell His
    Mouse Sirt7-5886M Recombinant Mouse Sirt7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Sirt7-1383R Recombinant Rat Sirt7 protein, His-tagged E.coli His
    Rat SIRT7-5410R Recombinant Rat SIRT7 Protein Mammalian Cell His
    Rhesus Macaque SIRT7-4207R Recombinant Rhesus monkey SIRT7 Protein, His-tagged Mammalian Cell His
    Chicken SIRT7-5512C Recombinant Chicken SIRT7 Mammalian Cell His

    sirt7 involved in several pathways and played different roles in them. We selected most pathways sirt7 participated on our site, such as Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class III, which may be useful for your reference. Also, other proteins which involved in the same pathway with sirt7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by HDAC Class I FKBP3; GATA1; SIRT2; GATA2; SIRT7; MXD1; NR2C1; PRMT5; SIRT5; WDR77
    Signaling events mediated by HDAC Class III SIRT7; SIRT2

    sirt7 has several biochemical functions, for example, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K18 specific), chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by sirt7 itself. We selected most functions sirt7 had, and list some proteins which have the same functions with sirt7. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K18 specific) SIRT7
    chromatin binding CAPNS2; SIX1; TP73; ACTL6A; ESR1; MEIS3; NCAPD3; LHX2; NPM2; RAG2
    metal ion binding ZSCAN20; ZFPM2A; NAALADL1; ATF7B; ZFP423; RFNG; KDM6B; ACSM2; CYP2K6; KLF8
    protein binding RABAC1; SIRT2; EDDM3B; VPS33B; KIAA0146; AASDHPPT; NUMA1; KRT6C; KCNN4; BRCC3

    sirt7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sirt7 here. Most of them are supplied by our site. Hope this information will be useful for your research of sirt7.

    MAGED1; CBX1

    Kiran, S; Chatterjee, N; et al. Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal. FEBS JOURNAL 280:3451-3466(2013).

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