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Official Full Name sirtuin 4
Background This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Synonyms SIRT4; sirtuin 4; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; NAD-dependent ADP-ribosyltransferase sirtuin-4; SIR2L4; sir2-like 4; sirt
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIRT4-111H Recombinant Human SIRT4 Protein, GST-tagged E. coli GST
    Human SIRT4-024H Recombinant Human SIRT4 Protein, GST-tagged E.coli GST
    Human SIRT4-1831HCL Recombinant Human SIRT4 293 Cell Lysate HEK293 N/A
    Human SIRT4-25H Recombinant Human SIRT4 protein, His-tagged E.coli His
    Human SIRT4-2682H Recombinant Human SIRT4, His-tagged E.coli His
    Human SIRT4-30844TH Recombinant Human SIRT4 E.coli N/A
    Human SIRT4-30846TH Recombinant Human SIRT4 E.coli N/A
    Human SIRT4-465H Recombinant Human SIRT4, GST-tagged E.coli GST
    Human SIRT4-4879H Recombinant Human Sirtuin 4, GST-tagged E.coli GST
    Mouse Sirt4-1377M Recombinant Mouse Sirt4 protein, His-tagged E.coli His
    Mouse SIRT4-15154M Recombinant Mouse SIRT4 Protein Mammalian Cell His
    Rat Sirt4-1378R Recombinant Rat Sirt4 protein, His-tagged E.coli His
    Zebrafish SIRT4-1513Z Recombinant Zebrafish SIRT4 Mammalian Cell His

    sirt4 involved in several pathways and played different roles in them. We selected most pathways sirt4 participated on our site, such as Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with sirt4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by HDAC Class I NR2C1; TFCP2; SIRT5; FKBP3; SIRT4; SIRT7; MXD1; PRMT5; WDR77; GATA2

    sirt4 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, NAD+ binding, NOT NAD-dependent protein deacetylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by sirt4 itself. We selected most functions sirt4 had, and list some proteins which have the same functions with sirt4. You can find most of the proteins on our site.

    Function Related Protein
    NAD+ ADP-ribosyltransferase activity GIG2E; TNKS2; GIG2P; PARP11; PARP14; PARP2; PARP12A; GIG2D; GIG2L; SIRT4
    NOT NAD-dependent protein deacetylase activity SIRT4
    biotinidase activity BTD; SIRT4
    lipoamidase activity SIRT4
    metal ion binding LOXL2B; CYP2J6; TREX1; MUT; ZNF266; GIT2B; Car14; ACLYA; NOB1; ZNF174
    protein binding MBNL3; SNAP47; TRIM55; POLG2; RPS6KB1; MXI1; RAP1B; CCS; NPC2; RAB2B

    sirt4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sirt4 here. Most of them are supplied by our site. Hope this information will be useful for your research of sirt4.


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