Recombinant Human IMPA1, His-tagged

• Cat.No.: IMPA1-2824H
• Product Overview: Recombinant human IMPA1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. MW = 32.3 kDa(297aa), confirmed by MALDI-TOF.

Specification

• Cat. No.: IMPA1-2824H
• Description: IMPA1 (inositol monophosphatase1) is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. It plays a key role in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis of inositol monophosphates. This protein has been identified as the pharmacological target for lithium action in the brain.
• Source: E.coli.
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPE TVRMVLSNME KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED
• Purity: > 95% by SDS - PAGE.
• Form: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 [ Homo sapiens ]
• Synonyms: IMPA1; inositol(myo)-1(or 4)-monophosphatase 1; IMP; IMPA; inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1; EC 3.1.3.25
• Gene ID: 3612
• mRNA Refseq: NM_001144878
• Protein Refseq: NP_001138350
• MIM: 602064
• UniProt ID: P29218
• Chromosome Location: 8q21.13-q21.3
• Pathway: Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system
• Function: hydrolase activity; identical protein binding; inositol-1(or 4)-monophosphatase activity; metal ion binding; protein homodimerization activity

Reviews

08/14/2022

It has good stability in different environments, and has thermal stability and acid-base stability.

05/02/2022

The storage method is simple and no special environment is required.

06/02/2021

In the experiment, the effect is remarkable, and it has strong stability.

Q&As

In which diseases is IMPA1 potentially useful?

This protein in the treatment of schizophrenia, bipolar disorder and mental disorders such as autism and muscle disease and potential application in organ transplantation.

What is the role of IMPA1 in autism?

This protein plays an important role in autism by regulating the glutamate signaling pathway and neuronal activity, affecting the development of the disease and the performance of social interaction.

How is IMPA1 involved in the development and progression of muscle diseases?

It can regulate phosphocreatine cycle and energy metabolism, and is associated with muscle diseases such as myasthenia and muscular atrophy.

How IMPA1 participate in organ transplantation immunity?

IMPA1 can regulate folate metabolism pathway and TH1/TH2 immune balance, and participate in the immune regulation of organ transplantation and the control of inflammatory response in vivo.

What is the role of IMPA1 in schizophrenia?

It plays an important role in schizophrenia, which can regulate the glutamate signaling pathway and the level of creatine in the brain, and affect the development of the disease and the performance of symptoms.

What is the role of IMPA1 in bipolar disorder?

This plays an important role in bipolar disorder, which can regulate the creatine cycle and glutamate signaling pathway, and affect the development of the disease and the stability of neurons.