Recombinant Human IMPA1 Protein, GST-tagged
Cat.No. : | IMPA1-5144H |
Product Overview : | Human IMPA1 full-length ORF ( AAH08381, 1 a.a. - 277 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 56.21 kDa |
AA Sequence : | MADPWQECMDYAVTLARQAGEVVCE AIKNEMNVMLKSSPVDLVTATDQKV EKMLISSIKEKYPSHSFIGEESVAA GEKSILTDNPTWIIDPIDGTTNFVH RFPFVAVSIGFAVNKKIEFGVVYSC VEGKMYTARKGKGAFCNGQKLQVSQ QEDITKSLLVTELGSSRTPETVRMV LSNMEKLFCIPVHGIRSVGTAAVNM CLVATGGADAYYEMGIHCWDVAGAG IIVTEAGGVLMDVTGGPFDLMSRRV IAANNRILAERIAKEIQVIPLQRDD ED |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 [ Homo sapiens ] |
Official Symbol : | IMPA1 |
Synonyms : | IMPA1; inositol(myo)-1(or 4)-monophosphatase 1; IMPA; inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1; IMP; |
Gene ID : | 3612 |
mRNA Refseq : | NM_001144878 |
Protein Refseq : | NP_001138350 |
MIM : | 602064 |
UniProt ID : | P29218 |
Products Types
◆ Recombinant Protein | ||
Impa1-3529M | Recombinant Mouse Impa1 Protein, Myc/DDK-tagged | +Inquiry |
IMPA1-2712R | Recombinant Rat IMPA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IMPA1-2712H | Recombinant Human IMPA1 protein(11-270 aa), C-His-tagged | +Inquiry |
IMPA1-841Z | Recombinant Zebrafish IMPA1 | +Inquiry |
IMPA1-29490TH | Recombinant Human IMPA1, His-tagged | +Inquiry |
◆ Lysates | ||
IMPA1-5214HCL | Recombinant Human IMPA1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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