Recombinant Human ERCC6 Protein, MYC/DDK-tagged

• Cat.No.: ERCC6-2113H
• Product Overview: Recombinant human ERCC6 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Description: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. [provided by RefSeq, Mar 2016]
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 168.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6 [ Homo sapiens ]
• Official Symbol: ERCC6
• Synonyms: ARMD5; CKN2; COFS; COFS1; CSB; RAD26; UVSS1
• Gene ID: 2074
• mRNA Refseq: NM_000124
• Protein Refseq: NP_000115
• MIM: 609413
• UniProt ID: Q03468