• Official Full Name

    excision repair cross-complementation group 3

  • Overview

    ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq, Jul 2008]
  • Synonyms

    ERCC3; excision repair cross-complementation group 3; XPB; BTF2; GTF2H; RAD25; TFIIH; TFIIH basal transcription factor complex helicase XPB subunit; BTF2 p89; TFIIH p89; TFIIH 89 kDa subunit; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; basic transcription factor 2 89 kDa subunit; xeroderma pigmentosum, complementation group B; xeroderma pigmentosum group B-complementing protein; TFIIH basal transcription factor complex 89 kDa subunit; excision repair cross-complementing rodent repair deficiency, complementation group 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ERCC3-2671H Active Recombinant Human ERCC3, His-tagged E.coli His
Human ERCC3-30702TH Recombinant Human ERCC3 Wheat Germ N/A 782 amino acids
Human ERCC3-3459H Recombinant Human ERCC3 Protein, GST-tagged Wheat Germ GST
Human ERCC3-6565HCL Recombinant Human ERCC3 293 Cell Lysate HEK293 N/A
Human ERCC3-1692H Recombinant Human ERCC3 protein, His & T7-tagged E.coli His/T7 Arg542~Ala702 (Accession # P19447)
Human ERCC3-4549HF Recombinant Full Length Human ERCC3 Protein, GST-tagged In Vitro Cell Free System GST 782 amino acids
Human ERCC3-158HF Recombinant Full Length Human ERCC3 Protein In Vitro Cell Free System 782 amino acids
Human ERCC3-2297H Recombinant Human ERCC3 Protein (Arg542-Ala702), N-His tagged E.coli N-His Arg542-Ala702
Human ERCC3-45433H Recombinant Human ERCC3 protein, GST-tagged E.coli N-GST 1-782aa
Mouse ERCC3-5286M Recombinant Mouse ERCC3 Protein Mammalian Cell His
Mouse ERCC3-2843M Recombinant Mouse ERCC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ERCC3-2843M-B Recombinant Mouse ERCC3 Protein Pre-coupled Magnetic Beads HEK293
Rat ERCC3-2137R Recombinant Rat ERCC3 Protein Mammalian Cell His
Rat ERCC3-1794R-B Recombinant Rat ERCC3 Protein Pre-coupled Magnetic Beads HEK293
Rat ERCC3-1794R Recombinant Rat ERCC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ERCC3-494C Recombinant Cynomolgus ERCC3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ERCC3-239C Recombinant Cynomolgus Monkey ERCC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ERCC3-239C-B Recombinant Cynomolgus Monkey ERCC3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ERCC3-1491R Recombinant Rhesus monkey ERCC3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ERCC3-1316R-B Recombinant Rhesus Macaque ERCC3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ERCC3-1316R Recombinant Rhesus Macaque ERCC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ERCC3-11564Z Recombinant Zebrafish ERCC3 Mammalian Cell His
Chicken ERCC3-1661C Recombinant Chicken ERCC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ERCC3 involved in several pathways and played different roles in them. We selected most pathways ERCC3 participated on our site, such as Basal transcription factors, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Basal transcription factorsTAF12;GTF2H3-2;TAF9B;GTF2H2;TAF1L;TBP;CCNH;TAF8;TAF6L
Nucleotide excision repairTFPT;BIVM-ERCC5;POLD4;POLE4;USP45;POLE2;RPA1;MCRS1;LIG1

ERCC3 has several biochemical functions, for example, 3-5 DNA helicase activity, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC3 itself. We selected most functions ERCC3 had, and list some proteins which have the same functions with ERCC3. You can find most of the proteins on our site.

Function Related Protein
3-5 DNA helicase activityGINS1;CDC45;WRN;ERCC3;FBXO18
ATP-dependent DNA helicase activityERCC2;DDX11;FBXO18;RTEL1;ERCC3;BRIP1;BLM;DDX3X;CHD4
contributes_to DNA-dependent ATPase activityGTF2H1;MNAT1;GTF2H4;BPTF;ERCC2;GTF2H2;ERCC3;RBBP4;GTF2H3
contributes_to RNA polymerase II carboxy-terminal domain kinase activityGTF2H2;ERCC3;GTF2H1;GTF2H3;ERCC2;MNAT1;GTF2H4
dATP bindingST13;ERCC3;HSP90AB1
protein C-terminus bindingSLC4A1;SAE1;DYNLL1;ERCC4;SDCBP2;HRAS;TAE1;KSR1;PHB
protein N-terminus bindingMAP2K1;MORF4L1;SNF8;NCOA1;TDRD7;CSNK2A1;PEX14;HAX1;DCTN4
protein bindingRTN4R;SPEF1;NCKAP1L;FRA10AC1;WRAP53;HSPB8;EDC3;RAB8A;ZNF329
contributes_to protein kinase activityGTF2H2;GTF2H1;GTF2H3;GTF2H4;ERCC3;ERCC2
transcription factor bindingMLXIPL;CDKN2A;TAF7L;TRIB1;KLF5;CD34;CEBPG;CDK9;TRP53

ERCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC3.

PSMC5; Psmc5; XIAP; CEP70; SRPK2; XPC; a8k1f4_human

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