ERCC3
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Official Full Name
excision repair cross-complementation group 3
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Overview
ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq, Jul 2008] -
Synonyms
ERCC3; excision repair cross-complementation group 3; XPB; BTF2; GTF2H; RAD25; TFIIH; TFIIH basal transcription factor complex helicase XPB subunit; BTF2 p89; TFIIH p89; TFIIH 89 kDa subunit; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; basic transcription factor 2 89 kDa subunit; xeroderma pigmentosum, complementation group B; xeroderma pigmentosum group B-complementing protein; TFIIH basal transcription factor complex 89 kDa subunit; excision repair cross-complementing rodent repair deficiency, complementation group 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ERCC3 involved in several pathways and played different roles in them. We selected most pathways ERCC3 participated on our site, such as Basal transcription factors, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal transcription factors | TBP;MNAT1;GTF2H2;TAF5;TAF6L;GTF2A1L;GTF2H3;GTF2I;TAF10 |
| Nucleotide excision repair | COPS2;ERCC4;MNAT1;POLD4;CUL4A;GPS1;RFC5;GTF2H3;INO80C |
ERCC3 has several biochemical functions, for example, 3-5 DNA helicase activity, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC3 itself. We selected most functions ERCC3 had, and list some proteins which have the same functions with ERCC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-5 DNA helicase activity | GINS1;ERCC3;WRN;FBXO18;CDC45 |
| ATP binding | NRBP1;PRKX;UBE2IB;DDX53;DDX28;P2RX3;AK7;CLCN3;MCM3L |
| ATP-dependent DNA helicase activity | CHD4;DHX9;BRIP1;CHD2;CHD1;RECQL;ERCC3;G3BP1;ERCC2 |
| ATPase activity | ATP13A;KIFC3;WRNIP1;Abca2;ERCC3;KIF27;KIF25;VWA8;KIF9 |
| DNA binding | ADNP2;CLOCK;TMEM18;POLR2H;EME2;NKX6.2;BAZ2B;ZBTB24;ZNF483 |
| contributes_to DNA-dependent ATPase activity | ERCC3;GTF2H4;RBBP4;ERCC2;GTF2H2;GTF2H3;MNAT1;BPTF;GTF2H1 |
| GTP binding | IIGP1;RAC3B;GNA15;TUBG1;GNA15.1;NKIRAS2;RAB3AA;GTPBP1;GMPPB |
| contributes_to RNA polymerase II carboxy-terminal domain kinase activity | ERCC3;GTF2H2;GTF2H4;GTF2H3;ERCC2;GTF2H1;MNAT1 |
| dATP binding | ST13;ERCC3;HSP90AB1 |
| damaged DNA binding | H2AFX;TP53;PNKP;RPS3;GTF2H3;APTX;HMGB1;NEIL2;RUVBL2 |
| peptide binding | ANPEPA;CTSB;OXTR;GNRHR;OXTRL;ANG;CALR;FURIN;AVPR1B |
| protein C-terminus binding | DLG3;CSK;SP1;AGO2;TAX1BP3;ATF4;PEX26;CDK7;IFT52 |
| protein N-terminus binding | PARP1;RPA2;RND2;NCOR2;SDCBP;ERCC6;MORF4L1;HAX1;DCTN4 |
| protein binding | DDX31;SSX3;RGR;GLB1;TH;GABPB2;FAM32A;SPINK1;SPATA7 |
| contributes_to protein kinase activity | GTF2H4;GTF2H3;GTF2H1;ERCC2;ERCC3;GTF2H2 |
| transcription factor binding | C1QBP;FOXO1;PBX1;ESR1;PPARG;THRA;EGR1;BCL3;KAT6B |
ERCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC3.
PSMC5; Psmc5; XIAP; CEP70; SRPK2; XPC; a8k1f4_human
Research Area
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