|Official Full Name||excision repair cross-complementing rodent repair deficiency, complementation group 2|
|Background||The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2; xeroderma pigmentosum complementary group D , XPD; TFIIH basal transcription factor complex helicase XPD subunit; EM9; excision repair cross complementing rodent|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ercc2 involved in several pathways and played different roles in them. We selected most pathways ercc2 participated on our site, such as Basal transcription factors, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ercc2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Basal transcription factors||GTF2E1; GTF2A1L; GTF2H5; TAF2; ERCC2; TAF6; TAF7; TBP; TAF13; TBPL1|
|Nucleotide excision repair||RFC5; CUL4B; INO80E; POLE; INO80; RFC3; GPS1; COPS3; ERCC4; XPC|
ercc2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, 5-3 DNA helicase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ercc2 itself. We selected most functions ercc2 had, and list some proteins which have the same functions with ercc2. You can find most of the proteins on our site.
|4 iron, 4 sulfur cluster binding||TYW1; DEM1; CDKAL1; POLD1; ETFDH; POLE; BRIP1; ERCC2; PPAT; NDUFS8B|
|5-3 DNA helicase activity||C10orf2; DNA2; ERCC2; PEO1|
|ATP binding||MOV10; AXL; TARSL2; CHD4A; DCLK2; WNK1; CAMK2D2; EPRS; UBE2U; P2RX5|
|ATP-dependent DNA helicase activity||GTF2H4; CHST13; DDX11; BRIP1; DHX9; ERCC3; CHD2; RUVBL2; XRCC5; WRN|
|DNA binding||HER2; SIX4; ZFP322A; ZNF554; APITD1; SCXB; BHLHA15; FOXO3B; SCRT1; ZIM3|
|contributes_to DNA-dependent ATPase activity||GTF2H2; MNAT1; GTF2H3; ERCC2; GTF2H4; RBBP4; GTF2H1; ERCC3; BPTF|
|DNA-dependent ATPase activity||TTF2; CDK7; RAD51D; RAD51B; ERCC2; IGHMBP2; MSH6; MSH5; XRCC3; MSH4|
|contributes_to RNA polymerase II carboxy-terminal domain kinase activity||ERCC3; GTF2H1; ERCC2; GTF2H4; GTF2H3; MNAT1; GTF2H2|
|metal ion binding||ZFP583; ZNF334; POLR3A; ATP2A3; CYP2X10.2; ISL2A; FGD4; SALL1; ZNF559; CYB5D1|
|protein C-terminus binding||PPM1A; HPCAL4; ARL6IP5; KCNK3; KSR1; DLG3; ERCC3; PFKM; PPP1R9B; SIAH1A|
|protein N-terminus binding||RPA2; PEX5; KCNQ2; SMARCC1; TSC1; ID1; SERPINB1A; LACRT; DCTN4; HAX1|
|protein binding||CCDC94; DDX23; NKD2; MATN1; ARNTL; CMTM3; TRIP6; FAM212A; C14orf118; ERCC6|
|contributes_to protein kinase activity||GTF2H3; GTF2H1; GTF2H2; ERCC2; ERCC3; GTF2H4|
ercc2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ercc2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ercc2.
GTF2H2C; b4dyc6_human; STIP1; HSF2; HSP90AB1; NUDCD3; q96be0_human; PPP5C; AARSD1; CACYBP; EGFR; CDK7; GTF2H5