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Official Full Name excision repair cross-complementing rodent repair deficiency, complementation group 2
Background The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms ERCC2; excision repair cross-complementing rodent repair deficiency, complementation group 2; xeroderma pigmentosum complementary group D , XPD; TFIIH basal transcription factor complex helicase XPD subunit; EM9; excision repair cross complementing rodent
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ERCC2-30131TH Recombinant Human ERCC2, His-tagged E.coli His
    Human ERCC2-3457H Recombinant Human ERCC2 Protein, GST-tagged Wheat Germ GST
    Human ERCC2-6566HCL Recombinant Human ERCC2 293 Cell Lysate HEK293 N/A
    Mouse ERCC2-5285M Recombinant Mouse ERCC2 Protein Mammalian Cell His
    Zebrafish ERCC2-11166Z Recombinant Zebrafish ERCC2 Mammalian Cell His

    ercc2 involved in several pathways and played different roles in them. We selected most pathways ercc2 participated on our site, such as Basal transcription factors, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ercc2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal transcription factors GTF2E1; GTF2A1L; GTF2H5; TAF2; ERCC2; TAF6; TAF7; TBP; TAF13; TBPL1
    Nucleotide excision repair RFC5; CUL4B; INO80E; POLE; INO80; RFC3; GPS1; COPS3; ERCC4; XPC

    ercc2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, 5-3 DNA helicase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ercc2 itself. We selected most functions ercc2 had, and list some proteins which have the same functions with ercc2. You can find most of the proteins on our site.

    Function Related Protein
    4 iron, 4 sulfur cluster binding TYW1; DEM1; CDKAL1; POLD1; ETFDH; POLE; BRIP1; ERCC2; PPAT; NDUFS8B
    5-3 DNA helicase activity C10orf2; DNA2; ERCC2; PEO1
    ATP binding MOV10; AXL; TARSL2; CHD4A; DCLK2; WNK1; CAMK2D2; EPRS; UBE2U; P2RX5
    ATP-dependent DNA helicase activity GTF2H4; CHST13; DDX11; BRIP1; DHX9; ERCC3; CHD2; RUVBL2; XRCC5; WRN
    DNA binding HER2; SIX4; ZFP322A; ZNF554; APITD1; SCXB; BHLHA15; FOXO3B; SCRT1; ZIM3
    contributes_to DNA-dependent ATPase activity GTF2H2; MNAT1; GTF2H3; ERCC2; GTF2H4; RBBP4; GTF2H1; ERCC3; BPTF
    DNA-dependent ATPase activity TTF2; CDK7; RAD51D; RAD51B; ERCC2; IGHMBP2; MSH6; MSH5; XRCC3; MSH4
    contributes_to RNA polymerase II carboxy-terminal domain kinase activity ERCC3; GTF2H1; ERCC2; GTF2H4; GTF2H3; MNAT1; GTF2H2
    metal ion binding ZFP583; ZNF334; POLR3A; ATP2A3; CYP2X10.2; ISL2A; FGD4; SALL1; ZNF559; CYB5D1
    protein C-terminus binding PPM1A; HPCAL4; ARL6IP5; KCNK3; KSR1; DLG3; ERCC3; PFKM; PPP1R9B; SIAH1A
    protein N-terminus binding RPA2; PEX5; KCNQ2; SMARCC1; TSC1; ID1; SERPINB1A; LACRT; DCTN4; HAX1
    protein binding CCDC94; DDX23; NKD2; MATN1; ARNTL; CMTM3; TRIP6; FAM212A; C14orf118; ERCC6
    contributes_to protein kinase activity GTF2H3; GTF2H1; GTF2H2; ERCC2; ERCC3; GTF2H4

    ercc2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ercc2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ercc2.

    GTF2H2C; b4dyc6_human; STIP1; HSF2; HSP90AB1; NUDCD3; q96be0_human; PPP5C; AARSD1; CACYBP; EGFR; CDK7; GTF2H5

    Yu, M; Bell, RH; et al. Deficiency in Nucleotide Excision Repair Family Gene Activity, Especially ERCC3, Is Associated with Non-Pigmented Hair Fiber Growth. PLOS ONE 7:-(2012).
    Capella, G; Pera, G; et al. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 37:1316-1325(2008).

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