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Official Full Name excision repair cross-complementing rodent repair deficiency, complementation group 8
Background This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Synonyms ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8; CKN1, Cockayne syndrome 1 (classical); DNA excision repair protein ERCC-8; CSA; Cockayne syndrome WD-repeat protein CSA; cockayne syndrome WD repeat protein CSA
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ERCC8-12527H Recombinant Human ERCC8, His-tagged E.coli His
    Human ERCC8-26850TH Recombinant Human ERCC8 Wheat Germ N/A
    Human ERCC8-3463H Recombinant Human ERCC8 Protein, GST-tagged Wheat Germ GST
    Human ERCC8-6562HCL Recombinant Human ERCC8 293 Cell Lysate HEK293 N/A
    Mouse ERCC8-5291M Recombinant Mouse ERCC8 Protein Mammalian Cell His
    Zebrafish ERCC8-1509Z Recombinant Zebrafish ERCC8 Mammalian Cell His

    ercc8 involved in several pathways and played different roles in them. We selected most pathways ercc8 participated on our site, such as DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with ercc8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dual incision in TC-NER TCEA1; ZFP830; ZNF830; ERCC8; PPIE; KIAA1530; DDB1
    Formation of TC-NER Pre-Incision Complex PPIE; DDB1; COPS6; COPS5; COPS7B; ZFP830; COPS8; KIAA1530; ZNF830; GPS1
    Gap-filling DNA repair synthesis and ligation in TC-NER DDB1; PPIE; ERCC8; ZFP830; ZNF830; KIAA1530; TCEA1
    Nucleotide Excision Repair MNAT1; POLD2; COPS7A; COPS7B; LIG1; CUL4B; RBX1; POLE; TFPT; COPS5
    Transcription-Coupled Nucleotide Excision Repair (TC-NER) COPS7A; COPS6; GPS1; COPS7B; COPS8; KIAA1530; PPIE; ZFP830; COPS3; COPS4
    Ubiquitin mediated proteolysis MDM2; KLHL9; UBE2U; UBE2J1; SIAH1; WWP2; TRIP12; CUL2; UBE2KA; HERC2

    ercc8 has several biochemical functions, for example, NOT DNA helicase activity, NOT DNA-dependent ATPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ercc8 itself. We selected most functions ercc8 had, and list some proteins which have the same functions with ercc8. You can find most of the proteins on our site.

    Function Related Protein
    NOT DNA helicase activity ERCC8; DNA2; ERCC6
    NOT DNA-dependent ATPase activity ERCC8
    protein binding CTCFL; YTHDF3; LINC01588; SPP1; PGF; PKP1; ZSCAN21; KRTAP9-4; LRP12; R3HDM2
    protein complex binding DRD1A; RNF40; SLC25A3; DLG4; ABI2; CDKN1B; NCOA1; RAN; NFYB; MAPK8IP2
    contributes_to ubiquitin-protein transferase activity RNF40; KLHL10; KLHL2; KLHL14; TCEB3B; KBTBD2; DBN1; KEAP1; KLHL15; ANAPC11

    ercc8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ercc8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ercc8.


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