|Official Full Name||excision repair cross-complementing rodent repair deficiency, complementation group 8|
|Background||This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.|
|Synonyms||ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8; CKN1, Cockayne syndrome 1 (classical); DNA excision repair protein ERCC-8; CSA; Cockayne syndrome WD-repeat protein CSA; cockayne syndrome WD repeat protein CSA|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ercc8 involved in several pathways and played different roles in them. We selected most pathways ercc8 participated on our site, such as DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with ercc8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|DNA Repair||TDP2; ALKBH3; SPRTN; PPIE; RBBP8; GPS1; SMARCA5; RAD1; COPS4; BARD1|
|Dual incision in TC-NER||TCEA1; ZFP830; ZNF830; ERCC8; PPIE; KIAA1530; DDB1|
|Formation of TC-NER Pre-Incision Complex||PPIE; DDB1; COPS6; COPS5; COPS7B; ZFP830; COPS8; KIAA1530; ZNF830; GPS1|
|Gap-filling DNA repair synthesis and ligation in TC-NER||DDB1; PPIE; ERCC8; ZFP830; ZNF830; KIAA1530; TCEA1|
|Nucleotide Excision Repair||MNAT1; POLD2; COPS7A; COPS7B; LIG1; CUL4B; RBX1; POLE; TFPT; COPS5|
|Transcription-Coupled Nucleotide Excision Repair (TC-NER)||COPS7A; COPS6; GPS1; COPS7B; COPS8; KIAA1530; PPIE; ZFP830; COPS3; COPS4|
|Ubiquitin mediated proteolysis||MDM2; KLHL9; UBE2U; UBE2J1; SIAH1; WWP2; TRIP12; CUL2; UBE2KA; HERC2|
ercc8 has several biochemical functions, for example, NOT DNA helicase activity, NOT DNA-dependent ATPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ercc8 itself. We selected most functions ercc8 had, and list some proteins which have the same functions with ercc8. You can find most of the proteins on our site.
|NOT DNA helicase activity||ERCC8; DNA2; ERCC6|
|NOT DNA-dependent ATPase activity||ERCC8|
|protein binding||CTCFL; YTHDF3; LINC01588; SPP1; PGF; PKP1; ZSCAN21; KRTAP9-4; LRP12; R3HDM2|
|protein complex binding||DRD1A; RNF40; SLC25A3; DLG4; ABI2; CDKN1B; NCOA1; RAN; NFYB; MAPK8IP2|
|contributes_to ubiquitin-protein transferase activity||RNF40; KLHL10; KLHL2; KLHL14; TCEB3B; KBTBD2; DBN1; KEAP1; KLHL15; ANAPC11|
ercc8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ercc8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ercc8.
XAB2; Ddb1; COPS6; COPS5; UQCRQ; CBR1; CSNK2B; CUL4B