ERCC8

  • Official Full Name

    excision repair cross-complementing rodent repair deficiency, complementation group 8

  • Overview

    This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
  • Synonyms

    ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8; CKN1, Cockayne syndrome 1 (classical); DNA excision repair protein ERCC-8; CSA; Cockayne syndrome WD-repeat protein CSA; cockayne syndrome WD repeat protein CSA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ERCC8-26850TH Recombinant Human ERCC8 Wheat Germ N/A 396 amino acids
Human ERCC8-3463H Recombinant Human ERCC8 Protein, GST-tagged Wheat Germ GST
Human ERCC8-12527H Recombinant Human ERCC8, His-tagged E.coli His 1-205a.a.
Human ERCC8-6562HCL Recombinant Human ERCC8 293 Cell Lysate HEK293 N/A
Human ERCC8-1436H Recombinant Human ERCC8 Protein, His&GST-tagged E.coli N-His&GST Met1-Gly396
Human ERCC8-160HF Recombinant Full Length Human ERCC8 Protein In Vitro Cell Free System 396 amino acids
Human ERCC8-4563HF Recombinant Full Length Human ERCC8 Protein, GST-tagged In Vitro Cell Free System GST 205 amino acids
Mouse ERCC8-5291M Recombinant Mouse ERCC8 Protein Mammalian Cell His
Mouse ERCC8-2845M Recombinant Mouse ERCC8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ERCC8-2845M-B Recombinant Mouse ERCC8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ercc8-1437M Recombinant Mouse Ercc8 Protein, His&GST-tagged E.coli N-His&GST Met1-Gly397
Zebrafish ERCC8-1509Z Recombinant Zebrafish ERCC8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ERCC8 involved in several pathways and played different roles in them. We selected most pathways ERCC8 participated on our site, such as DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA RepairRHNO1;SPRTN;EME2;RTEL1;USP10;ZNF830;ALKBH3;ASCC3;PAXIP1
Dual incision in TC-NERERCC8;KIAA1530;DDB1;TCEA1;ZNF830;PPIE;ZFP830
Formation of TC-NER Pre-Incision ComplexCOPS7B;COPS7A;KIAA1530;COPS8;COPS4;ZNF830;ZFP830;ERCC8;COPS3
Gap-filling DNA repair synthesis and ligation in TC-NERDDB1;PPIE;KIAA1530;ERCC8;TCEA1;ZNF830;ZFP830
Nucleotide Excision RepairGTF2H3;COPS6;INO80C;POLE;ERCC6;LIG1;YY1A;COPS5;ZNF830
Transcription-Coupled Nucleotide Excision Repair (TC-NER)COPS6;COPS7B;KIAA1530;GPS1;COPS7A;COPS8;ERCC8;ZNF830;COPS4
Ubiquitin mediated proteolysisRHOBTB2;VHL;UBE2G2;MGRN1;HUWE1;PML;UBE2D2A;TRAF6;CUL5

ERCC8 has several biochemical functions, for example, NOT DNA helicase activity, NOT DNA-dependent ATPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC8 itself. We selected most functions ERCC8 had, and list some proteins which have the same functions with ERCC8. You can find most of the proteins on our site.

Function Related Protein
NOT DNA helicase activityDNA2;ERCC6;ERCC8
NOT DNA-dependent ATPase activity
protein bindingPAX6;NKAP;ST6GAL1;HBD;IRAK1BP1;ITGB4;LARP1;CBX1;DHX40
protein complex bindingGNB2;CYFIP1;SHARPIN;MTHFR;HCLS1;UQCRC2;RBM10;ATG101;ATF1
contributes_to ubiquitin-protein transferase activityBARD1;KBTBD5;KLHL38;KLHL7;KBTBD7;RBX1;ANAPC11;DDB2;TCEB1

ERCC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC8.

XAB2; Ddb1; COPS6; COPS5; UQCRQ; CBR1; CSNK2B; CUL4B

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