ERCC6

  • Official Full Name

    excision repair cross-complementing rodent repair deficiency, complementation group 6

  • Overview

    This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B.

  • Synonyms

    ERCC6;excision repair cross-complementing rodent repair deficiency, complementation group 6;CSB;CKN2;COFS;ARMD5;COFS1;RAD26;DNA excision repair protein ERCC-6;Rad26 homolog;Cockayne syndrome B protein;ATP-dependent helicase ERCC6;cockayne syndrome protein CSB;Cockayne syndrome group B protein;OTTHUMP00000019581;EC 3.6.4.-;EC 3.6.1

Recombinant Proteins

  • Human
  • Mouse
  • Wheat Germ
  • E.coli
  • HEK293
  • Non
  • His
  • GST
  • DDK
  • Myc
  • T7
Cat.# Product name Source (Host) Species Tag Protein Length Price
ERCC6-26417TH Recombinant Human ERCC6 Wheat Germ Human Non 100 amino acids
ERCC6-2672H Recombinant Human ERCC6, His-tagged E.coli Human His
ERCC6-3461H Recombinant Human ERCC6 Protein, GST-tagged Wheat Germ Human GST
Ercc6-1435M Recombinant Mouse Ercc6 Protein, His-tagged E.coli Mouse His Gln13-Tyr179
ERCC6-2113H Recombinant Human ERCC6 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
ERCC6-2114H Recombinant Human ERCC6 Protein, His&T7-tagged E.coli Human His&T7 Val843~Tyr1002
Ercc6-2855M Recombinant Mouse Ercc6 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
ERCC6-4775H Recombinant Human ERCC6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc

    Involved Pathway

    ERCC6 involved in several pathways and played different roles in them. We selected most pathways ERCC6 participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nucleotide Excision Repair RAD23B,RPA1,RBX1,YY1,POLD2,CUL4B,GTF2H3-2,COPS6,RPA2,COPS8

    Protein Function

    ERCC6 has several biochemical functions, for example, ATP binding,DNA binding,NOT DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC6 itself. We selected most functions ERCC6 had, and list some proteins which have the same functions with ERCC6. You can find most of the proteins on our site.

    Function Related Protein
    protein N-terminus binding ID1,PDCD10,SMARCA4,SCT,GTF2H2,RPS21,ACOX1,NTSR1,TRAF6,SMARCC1
    DNA-dependent ATPase activity CDK7,SMARCA2,XRCC2,SMARCA4,DDX11,ERCC2,MSH3,MSH4,XRCC3,TOP2A
    DNA binding GCM2,ASCL4,POLR2F,FOXO1A,ZFP37,ZNF266,FOXA2,PBRM1,ZNF547,NR1D4B
    protein tyrosine kinase activator activity AFAP1L2,ABI1B,GHRL,PAK2,CD24,Cd24a,ABI1,NRG1,ABI3A,ABI1A
    ATP binding PAK3,PAPSS2A,DHX16,SRPK1B,UBE2Z,TPK1,GRK7,KIT,FAM20C,DMPK
    protein complex binding ATG101,PFKP,PROS1,MLKL,LRRC16A,NSF,CPS1,PPP2R2A,WRN,ST13
    NOT DNA helicase activity DNA2,ERCC8
    chromatin binding HMGB1A,SIRT2,SKIL,YAP1,TDRD3,MEIS1,CREBBP,RCC1,EED,UBTFL
    protein binding KBTBD7,COQ7,TRIM17,PHOSPHO2,ATP6V0A2,DUSP5,ASB6,NR2C2AP,PEPD,ATCAY

    Interacting Protein

    ERCC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC6.

    ERCC8;POLR2A;XAB2;NFKB1;RNF11;Srp72;CBX4;NOP56;CDK2AP1;Eif3a;RPL10;HNRNPU;BAX;HDAC1;Naa50;Rpl35;Mta1

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