ERCC1

  • Official Full Name

    excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

  • Overview

    The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision.
  • Synonyms

    ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); DNA excision repair protein ERCC-1; RAD10; UV20; COFS4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ERCC1-3455H Recombinant Human ERCC1 Protein, GST-tagged Wheat Germ GST
Human ERCC1-2396H Recombinant Human ERCC1 E.coli N/A
Human ERCC1-6778H Recombinant Human ERCC1, His-tagged E.coli His
Human ERCC1-12521H Recombinant Human ERCC1, GST-tagged E.coli GST 1-323a.a.
Human ERCC1-28691TH Recombinant Human ERCC1 E.coli N/A
Human ERCC1-6567HCL Recombinant Human ERCC1 293 Cell Lysate HEK293 N/A
Human ERCC1-6568HCL Recombinant Human ERCC1 293 Cell Lysate HEK293 N/A
Human ERCC1-2237H Recombinant Human ERCC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ERCC1-4665H Recombinant Human ERCC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ERCC1-4529HF Recombinant Full Length Human ERCC1 Protein, GST-tagged In Vitro Cell Free System GST 323 amino acids
Human ERCC1-2820H Recombinant Human ERCC1 Protein (Met1-Pro297), N-His tagged E.coli N-His Met1-Pro297
Human ERCC1-2821H Recombinant Human ERCC1 Protein (Met1-Pro323), His tagged E.coli His Met1-Pro323
Mouse Ercc1-972M Recombinant Mouse Ercc1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish ERCC1-5967Z Recombinant Zebrafish ERCC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ERCC1 involved in several pathways and played different roles in them. We selected most pathways ERCC1 participated on our site, such as Nucleotide excision repair, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nucleotide excision repairXPA;YY1A;CUL4B;RAD23A;COPS3;BIVM-ERCC5;RAD23B;POLE3;ACTR5
Fanconi anemia pathwayFANCG;SLX4;RAD51C;APITD1;ERCC1;FANCF;ERCC4;FUZ;STRA13

ERCC1 has several biochemical functions, for example, TFIID-class transcription factor binding, damaged DNA binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC1 itself. We selected most functions ERCC1 had, and list some proteins which have the same functions with ERCC1. You can find most of the proteins on our site.

Function Related Protein
TFIID-class transcription factor bindingNOP58;ZNHIT6;FBL;ERCC4;ERCC1
damaged DNA bindingTP63;POLI;TP53BP1;XRCC5;PCNA;TDG;XPC;RAD18;RBBP8
protein C-terminus bindingCALCOCO1;BLOC1S2;SAE1;PDZD3;TAX1BP3;MYO1C;CLIC6;PEX1;NCF2
protein bindingPPIAL4A;LILRB2;MFN2;LYL1;FRS3;KDM5B;SSB;FBXO11;RALGAPA1
protein domain specific bindingKCNN2;PRKAR2B;MYO7A;ATP1A1;RARA;TACC1;HIST1H4H;CALM1;NEDD4
single-stranded DNA bindingFBXO18;CSDA;MCM7;NEIL3;YBX1;TDP2;DDX11;SSBP2;CNBPA
contributes_to single-stranded DNA endodeoxyribonuclease activityRAD50;ERCC1
contributes_to structure-specific DNA bindingERCC4;ERCC1

ERCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC1.

UBL7; SLX4; EGFR

Research Area

Related articles

Kuhlmann, JD; Wimberger, P; et al. ERCC1-Positive Circulating Tumor Cells in the Blood of Ovarian Cancer Patients as a Predictive Biomarker for Platinum Resistance. CLINICAL CHEMISTRY 60:1282-1289(2014).
Dudas, J; Schartinger, VH; et al. Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer. TUMOR BIOLOGY 35:7807-7819(2014).
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