| Description : |
This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the vasopressin-like subfamily that also includes vasopressin and oxytocin receptors. The silencing of this gene, due to promoter methylation, is associated with ovarian cancer progression. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
46.2 kDa |
| AA Sequence : |
MEDLFSPSILPPAPNISVPILLGWG LNLTLGQGAPASGPPSRRVRLVFLG VILVVAVAGNTTVLCRLCGGGGPWA GPKRRKMDFLLVQLALADLYACGGT ALSQLAWELLGEPRAATGDLACRFL QLLQASGRGASAHLVVLIALERRRA VRLPHGRPLPARALAALGWLLALLL ALPPAFVVRGDSPSPLPPPPPPTSL QPGAPPAARAWPGERRCHGIFAPLP RWHLQVYAFYEAVAGFVAPVTVLGV ACGHLLSVWWRHRPQAPAAAAPWSA SPGRAPAPSALPRAKVQSLKMSLLL ALLFVGCELPYFAARLAAAWSSGPA GDWEGEGLSAALRVVAMANSALNPF VYLFFQAGDCRLRRQLRKRLGSLCC APQGGAEDEEGPRGHQALYRQRWPH PHYHHARREPLDEGGLRPPPPRPRP LPCSCESAFSGPTRTRRLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
