GPR68

  • Official Full Name

    G protein-coupled receptor 68

  • Overview

    Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.

  • Synonyms

    GPR68;G protein-coupled receptor 68;ovarian cancer G-protein coupled receptor 1;OGR1;G-protein coupled receptor 68;sphingosylphosphorylcholine receptor;ovarian cancer G protein-coupled receptor, 1;GPR12A;MGC111379;MGC156983

    Involved Pathway

    GPR68 involved in several pathways and played different roles in them. We selected most pathways GPR68 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR68 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G alpha (q) signalling events EDN1,ANXA1A,OPN4.1,DGKQ,QRFP,NMBB,KALRNB,LPAR5A,LPAR2A,TRH
    GPCRs, Class A Rhodopsin-like CCRL2,GPR17,GPR50,CCR8,NMUR1,DRD4,GPR45,SSTR1,GPR65,ADORA1
    Gastrin-CREB signalling pathway via PKC and MAPK OPN4.1,GPRC6A,NMBB,EDN2,NMUR1,GCGB,EDN1,RGS21,NPFF,EDN3
    Signal Transduction PYYA,UTS2D,RDH14A,RTN4,CCL35.2,OPN1LW1,PROKR1,NF2A,SDR9C7,CLPS
    GPCR downstream signaling RLN3A,HRH3,CHRM1,OR4D2,INSL3,CHRM3,FPR-RS3,GPR55,DRD5,FGD4A
    GPCR ligand binding SETD6,RHOL,KEL,EMR2,SST,PYYA,LPAR1,ADM2A,CYSLTR1,TAS2R13
    Osteoclast Signaling AIMP2
    Class A/1 (Rhodopsin-like receptors) INSL5,S1PR5B,EDN1,RGR,PTGDR2,EDNRA,ADORA1,PRLH,CXCL13,NMBA

    Protein Function

    GPR68 has several biochemical functions, for example, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR68 itself. We selected most functions GPR68 had, and list some proteins which have the same functions with GPR68. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity MCHR1,CALCRLA,MRGPRD,ADCYAP1R1A,MTNR1BB,GRIN1A,TAS2R117,F2RL1.2,OLFR13,OR2A42

    Interacting Protein

    GPR68 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR68 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR68.

    Resources

    Research Area

    References

    • Yang, MH; Mailhot, G; et al. Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis. JOURNAL OF BIOLOGICAL CHEMISTRY 281:23598-23605(2006).

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