Recombinant Mouse Unc13d Protein, Myc/DDK-tagged

• Cat.No.: Unc13d-6836M
• Product Overview: Purified recombinant protein of mouse full-length unc-13 homolog D (Unc13d), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 122.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Unc13d unc-13 homolog D [ Mus musculus (house mouse) ]
• Official Symbol: Unc13d
• Synonyms: UNC13D; unc-13 homolog D (C. elegans); protein unc-13 homolog D; likely ortholog of H. sapiens unc-13 homolog D (UNC13D); Jinx; Munc13-4; mFLJ00067; RP23-42F6.5; 2610108D09Rik; FLJ00067
• Gene ID: 70450
• mRNA Refseq: NM_001009573
• Protein Refseq: NP_001009573
• UniProt ID: B2RUP2