UNC13A

  • Official Full Name

    unc-13 homolog A
  • Overview

    This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play;important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be;associated with sporadic amyotrophic lateral sclerosis.
  • Synonyms

    UNC13A;unc-13 homolog A (C. elegans);protein unc-13 homolog A;KIAA1032;Munc13 1;Munc13-1

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
UNC13A-17840M Recombinant Mouse UNC13A Protein Mammalian Cells Mouse His
UNC13A-6444R Recombinant Rat UNC13A Protein Mammalian Cells Rat His
UNC13A-02H Recombinant Human UNC13A Protein, 1000-1703, His-tagged HEK293 Human His 1000-1703
UNC13A-1784H Recombinant Full Length Human UNC13A Protein, His tagged HEK293 Human His Full L.
UNC13A-4948H Recombinant Human UNC13A protein, His-tagged E.coli Human His 1-340aa
UNC13A-6100R Recombinant Rat UNC13A Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
UNC13A-6100R-B Recombinant Rat UNC13A Protein Pre-coupled Magnetic Beads HEK293 Rat
UNC13A-9909M Recombinant Mouse UNC13A Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
UNC13A-9909M-B Recombinant Mouse UNC13A Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    UNC13A involved in several pathways and played different roles in them. We selected most pathways UNC13A participated on our site, such as Synaptic vesicle cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Synaptic vesicle cycle NSF,ATP6V1E1,ATP6V0D2,SLC18A1,ATP6V1G2,SLC17A6,ATP6V0A4,VAMP2,ATP6V1C2,ATP6V1F

    Protein Function

    UNC13A has several biochemical functions, for example, SNARE binding,diacylglycerol binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13A itself. We selected most functions UNC13A had, and list some proteins which have the same functions with UNC13A. You can find most of the proteins on our site.

    Function Related Protein
    syntaxin-1 binding STXBP3,NSF,STXBP3A,CCDC167,SNPH,SNAP25B,VAMP2,VAMP3,SNAP25,CPLX1
    protein homodimerization activity TLR13,BCL2L2,P2RX4,TKT,EEA1,C6orf108,ZBTB4,EVLA,ACTN2,PEX7
    protein binding LEPROT,LETMD1,MEF2D,MAP2K6,ASCL3,FEZ1,CLEC18A,ACOT7,RPL13,TRIM25
    protein domain specific binding ARR3,RARA,VPS11,GUSB,BHLHE40,RAP2B,ATP1A1,TWIST2,ITGA3,HMGB2
    metal ion binding PLA2G4AA,PAPOLG,FTR43,ZNF566,RPE,ZNF438,ZNF143B,NGB,BTR18,ZSCAN16
    protein N-terminus binding RASSF1,PEX5,PPP1CC,DCTN4,SCFD1,NIPBL,ERCC3,ERCC2,DCN,ERCC4
    SNARE binding SEC22A,EXOC3,VAMP1,VTI1A,STX7,YKT6,STX2A,LRRK2,VAMP5,STX11A
    spectrin binding ANK1,PTPRN,CAMSAP1,KIF3A,PDE6G,GNB1,GBP1,EPB49,DCTN2,ADD2
    protein heterodimerization activity ADRA2A,TGFB3,KCNK9,BRAF,KCNA3,HIST1H2AG,ANO9A,HEXB,HMG20B,LIFR

    Interacting Protein

    UNC13A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13A here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13A.

    Ywhab

    Resources

    References

    • Luo, T; Kuriakose, JA; et al. Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization. INFECTION AND IMMUNITY 79:4382-4391(2011).
    • BROSE, N; HOFMANN, K; et al. MAMMALIAN HOMOLOGS OF CAENORHABDITIS-ELEGANS UNC-13 GENE DEFINE NOVEL FAMILY OF C-2-DOMAIN PROTEINS. JOURNAL OF BIOLOGICAL CHEMISTRY 270:25273-25280(1995).

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