UNC13A
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Official Full Name
unc-13 homolog A -
Overview
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play;important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be;associated with sporadic amyotrophic lateral sclerosis. -
Synonyms
UNC13A;unc-13 homolog A (C. elegans);protein unc-13 homolog A;KIAA1032;Munc13 1;Munc13-1
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UNC13A-17840M | Recombinant Mouse UNC13A Protein | Mammalian Cells | Mouse | His |
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| UNC13A-6444R | Recombinant Rat UNC13A Protein | Mammalian Cells | Rat | His |
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| UNC13A-02H | Recombinant Human UNC13A Protein, 1000-1703, His-tagged | HEK293 | Human | His | 1000-1703 |
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| UNC13A-4948H | Recombinant Human UNC13A protein, His-tagged | E.coli | Human | His | 1-340aa |
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| UNC13A-6100R | Recombinant Rat UNC13A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| UNC13A-6100R-B | Recombinant Rat UNC13A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| UNC13A-9909M | Recombinant Mouse UNC13A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| UNC13A-9909M-B | Recombinant Mouse UNC13A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
UNC13A involved in several pathways and played different roles in them. We selected most pathways UNC13A participated on our site, such as Synaptic vesicle cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Synaptic vesicle cycle | STX3,STX1A,ATP6V1E1,SLC17A6,CPLX2,ATP6V1C1,RIMS1,ATP6V0A4,ATP6V1C2,CPLX4 |
Protein Function
UNC13A has several biochemical functions, for example, SNARE binding,diacylglycerol binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13A itself. We selected most functions UNC13A had, and list some proteins which have the same functions with UNC13A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | VWF,GTF2H3,ERCC6,TBL1XR1,TP53,SMARCE1,SLA2,SMARCA4,SMARCC1,CSNK2A2 |
| syntaxin-1 binding | SNAP25A,CCDC167,RNF40,GOLSYN,SNAP25,MYO5A,VAMP3,STXBP2,DAPK1,NSF |
| protein homodimerization activity | TERF2,INHBB,KCNN2,CCL5,NR0B2,CCDC103,CADM1B,SYNE1,LDB1,TPD52L2 |
| protein binding | FAM161A,KRTAP10-7,CBR2,C2orf50,PDZD3,UPRT,COASY,TFIP11,FGF12,BRIP1 |
| metal ion binding | ZNF488,ZNF658,CHSY3,CBS,CMTM2A,ZFP13,KLF12B,PPM1L,MICALL2A,GNA14 |
| SNARE binding | STX11B.1,MYO5A,EXOC3L,STX11A,STX1B,GOSR1,ANKRD27,TNFAIP2A,VAMP5,STX4 |
| diacylglycerol binding | RASGRP3,CDIPT,UNC13B,RASGRP4,TRPC2,RASGRP1,UNC13C,RASGRP2 |
| protein domain specific binding | RAB27A,CASP2,CALM1,DRD3,CSNK2B,TFDP2,GNAI3,CHMP2A,SLC34A2,ARFIP2B |
| protein heterodimerization activity | HIST1H2BH,HIST3H2A,TGFB1,TAS1R3,HIST1H4L,EGFR,DVL3,NEFH,ARNT,TENM3 |
Interacting Protein
UNC13A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13A here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13A.
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References
- Luo, T; Kuriakose, JA; et al. Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization. INFECTION AND IMMUNITY 79:4382-4391(2011).
- BROSE, N; HOFMANN, K; et al. MAMMALIAN HOMOLOGS OF CAENORHABDITIS-ELEGANS UNC-13 GENE DEFINE NOVEL FAMILY OF C-2-DOMAIN PROTEINS. JOURNAL OF BIOLOGICAL CHEMISTRY 270:25273-25280(1995).
