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UNC5B

  • Official Full Name

    unc-5 homolog B (C. elegans)

  • Overview

    This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
  • Synonyms

    UNC5B; unc-5 homolog B (C. elegans); unc5 (C.elegans homolog) b; netrin receptor UNC5B; p53RDL1; UNC5H2; 6330415E02Rik; A630020F16; D10Bwg0792e; Netrin receptor UNC5B Precursor; p53 regulated receptor for death and life; p53 regulated receptor for death and life protein 1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; Protein unc-5 homolog B; Protein XUNC 5; Transmembrane receptor Unc5H2; Unc 5 homolog 2; Unc 5 homolog B; UNC 5B; UNC5B_HUMAN; unc-5 homolog 2; OTTHUMP00000019771; OTTHUMP00000019772;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • hFc
  • Fc
  • hIgG
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UNC5B-2438H Recombinant Human Unc-5 Homolog B (C. Elegans), Fc Chimera CHO Fc
Human UNC5B-31670TH Recombinant Human UNC5B, Fc-tagged HEK293 Fc 336 amino acids
Human Unc5b-2439M Recombinant Mouse Unc-5 Homolog B (C. Elegans), Fc Chimera HEK293 Fc
Human UNC5B-555H Recombinant Human UNC5B protein(Met1-Pro363), hFc-tagged HEK293 C-hFc Met1-Pro363
Human UNC5B-556H Recombinant Human UNC5B Protein, His-tagged HEK293 His
Human UNC5B-634H Recombinant Human UNC5B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse UNC5B-17848M Recombinant Mouse UNC5B Protein Mammalian Cell His
Mouse Unc5b-330M Recombinant Mouse Unc5b Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse UNC5B-9917M-B Recombinant Mouse UNC5B Protein Pre-coupled Magnetic Beads HEK293
Mouse UNC5B-9917M Recombinant Mouse UNC5B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Unc5b-915R Active Recombinant Rat Unc5b Protein, Fc Chimera Mammalian cells Fc
Rat UNC5B-101R Recombinant Rat Unc5b, Fc tagged Human Cell His
Rat UNC5B-6451R Recombinant Rat UNC5B Protein Mammalian Cell His
Rat UNC5B-767RCL Recombinant Rat UNC5B cell lysate Human Cell N/A
Rat Unc5b-22R-B Recombinant Rat Unc5b Protein Pre-coupled Magnetic Beads HEK293
Rat Unc5b-005R Recombinant Rat Unc5b Protein, hIgG/His-tagged HEK293 hIgG/His 27-373aa
Rat UNC5B-2181R Recombinant Rat UNC5B protein, hFc-tagged HEK293 hFc Met1-Asp373
Rat Unc5b-039R Recombinant Rat Unc5b Protein, hIgG/His-tagged HEK293 hIgG/His
Rat Unc5b-22R Recombinant Rat Unc5b Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish UNC5B-6223Z Recombinant Zebrafish UNC5B Mammalian Cell His
Chicken UNC5B-2887C Recombinant Chicken UNC5B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UNC5B Related Articles
  • UNC5B Related Research Area

UNC5B involved in several pathways and played different roles in them. We selected most pathways UNC5B participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceEFNA4;EVL;PHB;KBTBD7;EPHB3;NRG2A;EFNB2A;KDR;CLASP1

UNC5B has several biochemical functions, for example, netrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC5B itself. We selected most functions UNC5B had, and list some proteins which have the same functions with UNC5B. You can find most of the proteins on our site.

Function Related Protein
netrin receptor activityUNC5C;Unc5b
protein bindingTNNI3;CXCL11;TFCP2;BCKDHB;ABCC2;CASKIN1;DPYSL4;WDR48;UPF1

UNC5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC5B here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC5B.

Agap2; Ppp2r1b

Tu, T; Zhang, CX; et al. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. CELL RESEARCH 25:275-287(2015).
Oksala, N; Parssinen, J; et al. Association of Neuroimmune Guidance Cue Netrin-1 and Its Chemorepulsive Receptor UNC5B With Atherosclerotic Plaque Expression Signatures and Stability in Human(s) Tampere Vascular Study (TVS). CIRCULATION-CARDIOVASCULAR GENETICS 6:579-587(2013).
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