| Description : |
STK32A (Serine/Threonine Kinase 32A) is a serine/threonine protein kinase that is expressed in a variety of tissues, including the brain, liver, and heart. STK32A has been implicated in the regulation of several cellular processes, including cell proliferation, cell survival, and autophagy. Research has suggested that STK32A may play a role in the development and progression of cancer. STK32A has been shown to be overexpressed in several types of cancer, including lung cancer, breast cancer, and ovarian cancer, and high levels of STK32A expression have been associated with poor prognosis. Additionally, STK32A has been suggested as a potential therapeutic target in cancer, and efforts to develop small-molecule inhibitors of the kinase are underway. |
| Source : |
Sf21 |
| Species : |
Human |
| Tag : |
His |
| Protein length : |
Full Length |
| Form : |
2.45mg/ml of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Bio-activity : |
16U/mg, where one unit of STK32A activity is defined as 1nmol phosphate incorporated into 2mg/ml casein per minute at 30 centigrade with a final ATP concentration of 100μM. |
| Molecular Mass : |
50 kDa |
| AA Sequence : |
1 MSYYHHHHHH DYDIPTTENL YFQGAMDPEF MGANTSRKPP VFDENEDVNF DHFEILRAIG 61 KGSFGKVCIV QKNDTKKMYA MKYMNKQKCV ERNEVRNVFK ELQIMQGLEH PFLVNLWYSF 121 QDEEDMFMVV DLLLGGDLRY HLQQNVHFKE ETVKLFICEL VMALDYLQNQ RIIHRDMKPD 181 NILLDEHGHV HITDFNIAAM LPRETQITTM AGTKPYMAPE MFSSRKGAGY SFAVDWWSLG 241 VTAYELLRGR RPYHIRSSTS SKEIVHTFET TVVTYPSAWS QEMVSLLKKL LEPNPDQRFS 301 QLSDVQNFPY MNDINWDAVF QKRLIPGFIP NKGRLNCDPT FELEEMILES KPLHKKKKRL 361 AKKEKDMRKC DSSQTCLLQE HLDSVQKEFI IFNREKVNRD FNKRQPNLAL EQTKDPQGED 421 GQNNNL |
| Purity : |
Purity 85% by SDS-PAGE and Coomassie blue staining. |
| Applications : |
Drug Discovery & Development |
| Storage : |
1 year at -70 centigrade. |
| Handling Advice : |
Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade. |
| Use/Stability : |
On receipt of material store at -70 centigrade. Unopened reagent is stable for a minimum of 1 year from date of shipment when stored at recommended storage temperature. Avoid repeat freeze/thaw cycles. For maximum recovery of product, centrifuge original vial prior to removing the cap. |
