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Official Full Name serine/threonine kinase 3
Background This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein;functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal;portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which;promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have;been found for this gene.
Synonyms STK3; serine/threonine kinase 3; serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; KRS1; MST2; MST-2; STE20-like kinase MST2; mammalian STE20-like protein kinase 2; serine/threonine-protein kinase Krs-1; serine/threonine
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STK3-1405HCL Recombinant Human STK3 293 Cell Lysate HEK293 N/A
    Human STK3-1486H Recombinant Human STK3 (Active), GST-tagged Sf9 Insect Cell GST
    Human STK3-437H Recombinant Human STK3, GST-tagged, Active Sf9 Insect Cell GST
    Human Stk3-669H Recombinant Human Stk3 Protein, His-tagged E.coli His
    Human STK3-731H Recombinant Human Serine/threonine Kinase 3 (STE20 Homolog, Yeast) Sf9 Insect Cell N/A
    Mouse STK3-16139M Recombinant Mouse STK3 Protein Mammalian Cell His
    Mouse Stk3-6188M Recombinant Mouse Stk3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat STK3-5793R Recombinant Rat STK3 Protein Mammalian Cell His
    Rhesus Macaque STK3-4527R Recombinant Rhesus monkey STK3 Protein, His-tagged Mammalian Cell His
    Chicken STK3-2991C Recombinant Chicken STK3 Mammalian Cell His
    Zebrafish STK3-10071Z Recombinant Zebrafish STK3 Mammalian Cell His

    STK3 involved in several pathways and played different roles in them. We selected most pathways STK3 participated on our site, such as MAPK signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway GRB2B; MAP4K4; KCNA3; MAPK12; MAX; CASP3A; MAP4K2; PLA2G4C; GNG12; RAC1A
    Hippo signaling pathway SCRIB; AMH; MOBKL1A; WNT5A; AXIN1; CDH1; LATS1; FZD1; TEAD4; ID2

    STK3 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK3 itself. We selected most functions STK3 had, and list some proteins which have the same functions with STK3. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase kinase activity MAP3K13; YSK4; MAP3K8; RAF1; MAP3K1; STK3; TAOK2; BRAF; MAP3K15; STK4
    magnesium ion binding PGM2; OPA1; NCS1; ABL2; GCLC; NEK6; ENO3; PPM1N; MARK2; STK4
    protein binding HSPA14; VTI1B; NEDD4; IARS; ALOX5AP; E2F3; ZBTB5; NUDC; MON1B; TGIF1
    protein dimerization activity MXD4; TCF3B; MXI1; HER7; NCOA1; ATOH1B; HER4.3; SMG1; HER12; LDB1A
    protein kinase activity SGK196; TAOK1; CDK5; PRKCDA; PTK6B; GSK3AA; PRKCA; SBK1; STK17B; JAK2A
    protein serine/threonine kinase activator activity STK4; CALM1; SPRY2; ALS2; CALM2; PARP16; CALM3; FAM20A; STRADA; CDK5R1
    protein serine/threonine kinase activity MAPKAPK5; NIM1; ROCK2A; SNRKA; ACVR1BA; PKN1; RAF1B; PIK3CG; UHMK1; RPS6KA3B

    STK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK3.

    SAV1; STK4

    Hammer, A; Oladimeji, P; et al. Phosphorylation of tyrosine 285 of PAK1 facilitates beta PIX/GIT1 binding and adhesion turnover. FASEB JOURNAL 29:943-959(2015).
    Kamato, D; Rostam, MA; et al. Transforming growth factor beta-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. JOURNAL OF PHARMACY AND PHARMACOLOGY 66:1722-1733(2014).

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