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STK3

  • Official Full Name

    serine/threonine kinase 3

  • Overview

    This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein;functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal;portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which;promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have;been found for this gene.
  • Synonyms

    STK3; serine/threonine kinase 3; serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; KRS1; MST2; MST-2; STE20-like kinase MST2; mammalian STE20-like protein kinase 2; serine/threonine-protein kinase Krs-1; serine/threonine;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • SUMO
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STK3-1486H Active Recombinant Human STK3, GST-tagged Sf9 Insect Cell GST Full length
Human STK3-164H Active Recombinant Human STK3(2-end) Protein, N-His-tagged Sf21 His 2-end
Human STK3-731H Recombinant Human Serine/threonine Kinase 3 (STE20 Homolog, Yeast) Sf9 Insect Cell N/A
Human STK3-437H Recombinant Human STK3, GST-tagged, Active Sf9 Insect Cell GST
Human STK3-1405HCL Recombinant Human STK3 293 Cell Lysate HEK293 N/A
Human STK3-1232H Recombinant Human STK3 Protein (M1-F491), GST tagged Insect Cell GST M1-F491
Human STK3-1231H Recombinant Human STK3 Protein (M1-F491), Tag Free Insect Cell No tag M1-F491
Human Stk3-669H Recombinant Human Stk3 Protein, His-tagged E.coli His Thr235~Ala460
Human STK3-7040HF Active Recombinant Full Length Human STK3 Protein, GST-tagged Insect (sf21) GST 1-491
Mouse STK3-16139M Recombinant Mouse STK3 Protein Mammalian Cell His
Mouse Stk3-6188M Recombinant Mouse Stk3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Stk3-1243M Recombinant Mouse Stk3 Protein, His&SUMO-tagged E.coli N-His&SUMO Thr235-Ala460
Mouse STK3-8805M Recombinant Mouse STK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse STK3-8805M-B Recombinant Mouse STK3 Protein Pre-coupled Magnetic Beads HEK293
Rat STK3-5793R Recombinant Rat STK3 Protein Mammalian Cell His
Rat STK3-5452R Recombinant Rat STK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat STK3-5452R-B Recombinant Rat STK3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque STK3-4527R Recombinant Rhesus monkey STK3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque STK3-4343R Recombinant Rhesus Macaque STK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque STK3-4343R-B Recombinant Rhesus Macaque STK3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish STK3-10071Z Recombinant Zebrafish STK3 Mammalian Cell His
Chicken STK3-2991C Recombinant Chicken STK3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • STK3 Related Articles
  • STK3 Related Research Area

STK3 involved in several pathways and played different roles in them. We selected most pathways STK3 participated on our site, such as MAPK signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF6A;TRAF2;STMN1;MAPKAPK5;PPM1NA;HSPA2;MAP3K2;RAP1B;RAC3B
Hippo signaling pathwaySAV1;PPP1CC;PPP2R2B;PPP2CA;WNT4;TP73;AREG;MOBKL1A;FRMD6

STK3 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK3 itself. We selected most functions STK3 had, and list some proteins which have the same functions with STK3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTAOK3;DNAH11;TRPV4;RTEL1;UBE2L3A;SMARCA2;HSPA4A;PAK2;CSNK2A1
MAP kinase kinase kinase activityMAP3K6;STK3;STK4;TAOK2;MAP3K4;MAP3K8;BRAF;MAP3K13;YSK4
magnesium ion bindingAtp8a2;CLYBL;GTPBP5;ENOSF1;FOXK2;HACL1;CDC42BPA;TSSK1;PPM1AB
protein bindingMALSU1;NOD1;TPRKB;RPL15;ARHGEF12;CAML;DCUN1D1;SSX2;NR0B1
protein dimerization activitySREBF1;AIFM1;DAO1;NPAS4A;TFEC;OLIG4;ID4;SREBF2;HER1
protein kinase activityBRAF;TRIOA;WNK2;NLK1;CDC42BPB;ERBB3A;EPHA1;CDC7;MAP4K1
protein serine/threonine kinase activator activityPARP16;LTF;STK4;CALM1;CALM3;MAP2K1;SPRY2;CALM2;FAM20A
protein serine/threonine kinase activityGSK3B;MARK3;MAPK1;TGFBR1A;CAMK2D2;TNNI3K;SMOK3A;CHEK2;MAPK12

STK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK3.

SAV1; STK4

Hammer, A; Oladimeji, P; et al. Phosphorylation of tyrosine 285 of PAK1 facilitates beta PIX/GIT1 binding and adhesion turnover. FASEB JOURNAL 29:943-959(2015).
Kamato, D; Rostam, MA; et al. Transforming growth factor beta-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. JOURNAL OF PHARMACY AND PHARMACOLOGY 66:1722-1733(2014).
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