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Official Full Name serine/threonine kinase 4
Background The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and its possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Synonyms STK4; serine/threonine kinase 4; KRS2; MST1; YSK3; TIIAC; serine/threonine-protein kinase 4; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2));
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STK4-30118H Recombinant Human STK4 protein, GST-tagged E.coli GST
    Human STK4-1862H Recombinant Human STK4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human STK4-2960H Recombinant Human STK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human STK4-30251TH Recombinant Human STK4 N/A
    Human STK4-604HCL Recombinant Human STK4 cell lysate Insect Cell N/A
    Human STK4-709H Recombinant Human Serine/Threonine Kinase 4, GST-His Sf9 Insect Cell GST
    Human STK4-954H Recombinant Human STK4, His tagged Insect Cell His
    Mouse Stk4-6194M Recombinant Mouse Stk4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque STK4-4530R Recombinant Rhesus monkey STK4 Protein, His-tagged Mammalian Cell His
    Chicken STK4-2548C Recombinant Chicken STK4 Mammalian Cell His

    stk4 involved in several pathways and played different roles in them. We selected most pathways stk4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with stk4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNB3A; MAPK4; CACNA2D2; TGFB3; CACNG1; ELK4; STK4; NLK1; SOS1; CACNA1G
    Ras signaling pathway MAPK9; PLA2G2E; EFNA4; FGFR3; RELA; MAPK8; FGF6; RGL1; FGF1; SHC4
    FoxO signaling pathway MAPK13; S1PR1; HRASA; KLF2B; PIK3CG; PLK4; CCNB3; NLK1; SGK1; GRM1
    Pathways in cancer IGF1; ZBTB16; NFKBIA; MDM2; AGTR1B; IGF1R; CYCS; Fgf15; GLI3; LAMB4
    Non-small cell lung cancer EML4; PIK3CA; CASP9; RB1; STK4; PRKCG; HRAS; TP53; SOS1; FHIT

    stk4 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by stk4 itself. We selected most functions stk4 had, and list some proteins which have the same functions with stk4. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase kinase activity MAP3K15; MAP3K8; MAP3K5; MAP3K6; MAP3K4; BRAF; TAOK2; MAP3K12; MAP3K13; MOS
    identical protein binding VCP; HOOK1; C1QL2; PSMA7; CLPP; PDCD6; ATL1; VAMP2; NOL3; HGF
    magnesium ion binding NLK; COMTA; PRPSAP1; GCLC; PRPS1A; NT5C1BA; ITPK1; EYA2; STK11; FAN1
    protein binding LAIR1; RPS10; MAP1B; OCIAD1; CCNL2; FGF21; THG1L; SULT1E1; JIP1; CD14
    protein dimerization activity FIGLA; HIF1AB; MAX; ATOH1; RIMKLB; CLOCK; PTF1A; NCOA3; ID2B; SRFB
    protein homodimerization activity SMAGP; BAXA; CADM2; DNTTIP1; TPD52L1; TREX2; ALDH1A3; BOKA; ACTN3; SLC22A6
    protein kinase activity MAP3K11; STK25A; DAPK2A; PTK2AB; EPHB4A; BMPR2B; RNASEL; PLK1; PRKACAA; CDK5R1
    protein serine/threonine kinase activator activity STRADA; CDK5R1; MAP2K2; CALM2; MAP2K1; IGF2; LTF; CALM1; STK4; SPRY2
    protein serine/threonine kinase activity PRKCE; TSSK5; MAPK12B; PSKH1; AAK1; SMOK3A; PIK3CA; PRKD2; PINK1; CDC7
    transcription factor binding GATA2; GNPTAB; TMEM173; PSMC5; HEYL; TRIM6; TRIB2; SIX2; MYBBP1A; NKX2-5

    stk4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with stk4 here. Most of them are supplied by our site. Hope this information will be useful for your research of stk4.

    SAV1; RASSF2

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