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Official Full Name serine/threonine kinase 4
Background The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and its possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Synonyms STK4; serine/threonine kinase 4; KRS2; MST1; YSK3; TIIAC; serine/threonine-protein kinase 4; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2));
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STK4-2960H Recombinant Human STK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human STK4-30251TH Recombinant Human STK4 N/A
    Human STK4-361H Recombinant Human Serine/Threonine Kinase 4, GST-tagged, Active Sf9 Insect Cell GST
    Human STK4-604HCL Recombinant Human STK4 cell lysate Insect Cell N/A
    Human STK4-709H Recombinant Human Serine/Threonine Kinase 4, GST-His Sf9 Insect Cell GST
    Human STK4-954H Recombinant Human STK4, His tagged Insect Cell His
    Rhesus Macaque STK4-4530R Recombinant Rhesus monkey STK4 Protein, His-tagged Mammalian Cell His
    Chicken STK4-2548C Recombinant Chicken STK4 Mammalian Cell His

    stk4 involved in several pathways and played different roles in them. We selected most pathways stk4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with stk4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway RAP1AB; FLNA; PPM1AB; RPS6KA3; FGF6A; RAC2; ACVR1C; MRAS; CACNG4; GRB2B
    Ras signaling pathway RASAL3; NGF; SOS1; KRAS; GNG7; Kitl; PDGFRB; PGF; FGF19; RRAS2
    FoxO signaling pathway CCND2A; RAG1; MDM2; HOMER1B; SMAD2; PLK1; KLF2B; EP300; BCL6A; AKT3A
    Pathways in cancer TRAF6; PTK2; NRAS; TRAF2; PDGFRA; PDGFB; TCF7L2; FGFR3; CDH1; PLCB1
    Non-small cell lung cancer RXRB; STK4; NRAS; CCND1; PIK3CG; BAD; PIK3CA; PIK3CB; PRKCA; RARB

    stk4 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by stk4 itself. We selected most functions stk4 had, and list some proteins which have the same functions with stk4. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase kinase activity RAF1; MAP3K3; MOS; ALPK2; MAP3K14; KIAA1804; TAOK3; BRAF; MAP3K2; MAP3K4
    identical protein binding TK1; G6PD; IFI16; MAP1S; CLDN23; KIRRELA; TRIM39; AHI1; TYROBP; CEP72
    magnesium ion binding ATP8B5; COMT; COMTB; PAPOLA; PPA1A; ERN1; PTEN; SPHK1; SRPK2; PRPSAP1
    protein binding FBN1; OSGIN1; AGPAT5; ANKRD10; SCNN1G; BEX1; C1orf51; FIBCD1; DNAJA3; DEF6
    protein dimerization activity MESPBB; MYO5A; GGN; NCOA3; TCF23; ASCL3; BETA3; NCOA2; STK4; HES4
    protein homodimerization activity CRTAM; AXIN1; NRF1; TYW5; TENM2; ACTN4; SLC24A6; KLHL7; GPD1L; CHRNA7
    protein kinase activity SGK3; MAPKAPK2; DCLK1; MAP3K5; PRKACAA; CSNK1G2A; MYO3A; Fert2; LIMK1; PTK2AA
    protein serine/threonine kinase activator activity LTF; MAP2K2; CDK5R1; ALS2; FAM20A; STK4; CALM2; STRADA; CALM1; STK3
    protein serine/threonine kinase activity STK39; MASTL; TSSK1; TGFBR1B; LRRK2; ACVR1BA; MAP2K2; PDPK1; MAP3K4; RAF1B
    transcription factor binding RPS3; HEYL; SIRT1; EGR1; TFDP1; ESRRB; PIM1; PRICKLE1; HDAC2; SIRT2

    stk4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with stk4 here. Most of them are supplied by our site. Hope this information will be useful for your research of stk4.

    SAV1; RASSF2

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