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Official Full Name serine/threonine kinase 11
Background This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Synonyms STK11; serine/threonine kinase 11; PJS; LKB1; hLKB1; serine/threonine-protein kinase STK11; liver kinase B1; polarization-related protein LKB1; renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STK11-1410HCL Recombinant Human STK11 293 Cell Lysate HEK293 N/A
    Human STK11-23H Recombinant Human STK11 protein, His-tagged E.coli His
    Human STK11-240H Recombinant Human STK11 protein, GST/His-tagged E.coli GST/His
    Human STK11-29853TH Recombinant Human STK11, His-tagged E.coli His
    Mouse STK11-16132M Recombinant Mouse STK11 Protein Mammalian Cell His
    Mouse STK11-2814M Recombinant Mouse STK11 Protein (1-433 aa), His-Myc-tagged Insect Cell His/Myc
    Mouse Stk11-668M Recombinant Mouse Stk11 Protein, His-tagged E.coli His
    Rhesus Macaque STK11-4524R Recombinant Rhesus monkey STK11 Protein, His-tagged Mammalian Cell His
    Chicken STK11-3493C Recombinant Chicken STK11 Mammalian Cell His
    Zebrafish STK11-2563Z Recombinant Zebrafish STK11 Mammalian Cell His

    STK11 involved in several pathways and played different roles in them. We selected most pathways STK11 participated on our site, such as FoxO signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway CCNB2; PTEN; INSR; FOXO3B; TGFB1; GRB2B; MAP2K2; SMAD3; GABARAPL2; PLK1
    mTOR signaling pathway PRKAA2; ULK1; PDPK1; MLST8; RPS6; TNF; PRKAA1; DEPDC6; ULK2; MAPK1
    PIK-Akt signaling pathway FGF14; ITGA2B; IFNA17; GH1; FGFR3; SOS1; FGF12; Gh; STK11; PTEN
    AMPK signaling pathway CREB3; PPP2R5B; PPP2R5E; CREB3L2; SLC2A4; IRS4; LEP; ULK1; PRKAG1; CRTC2
    Adipocytokine signaling pathway MTOR; AKT3A; PRKAG3; IRS4; PCK1; NFKBIAB; MAPK9; PTPN11; CAMKK1; G6PC

    STK11 has several biochemical functions, for example, ATP binding, LRR domain binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK11 itself. We selected most functions STK11 had, and list some proteins which have the same functions with STK11. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ACSM2; CSF1RA; Abca2; GUK1; AK9; RFC2; MYO5A; FER; JAK2; LIG4
    LRR domain binding STK11; POLR2J; ZXDC; LRRFIP2; ROBO1; KRAS
    magnesium ion binding BPNT1; OPA1; ATP9B; PPM1AA; PDXK; MTHFD2; IRAK4; PDXP; DOM3Z; TSSK1
    p53 binding RNF34; BRD4; GATA1; CDKN2A; BCL2L12; TP53; HSPD1; PTTG1IP; STK11; RCHY1
    protein binding RNF10; HDDC3; BRAP; GEMIN4; SEPHS1; USP34; PHYH; PDCD4; GSG2; WNT2
    protein complex binding CRHR1; ATM; NASP; CFLAR; PDX1; ATP6V1B1; LCA5; EPCAM; RRAS; NCK2
    protein kinase activator activity STRADA; MAPK8IP2; NKX3; DAXX; CAB39; FAM58A; MT3; EPO; GPRC5B; FGF13
    protein serine/threonine kinase activity DYRK3; MLKL; OXSR1A; PLK2; MAPK14B; PIM2; NEK12; ULK1; MAPK4; MOK

    STK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK11.


    Nakada, Y; Stewart, TG; et al. The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues. PLOS ONE 8:-(2013).
    Zhong, DS; Liu, XJ; et al. LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. CANCER RESEARCH 68:7270-7277(2008).

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