STK11

  • Official Full Name

    serine/threonine kinase 11

  • Overview

    This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    STK11; serine/threonine kinase 11; PJS; LKB1; hLKB1; serine/threonine-protein kinase STK11; liver kinase B1; polarization-related protein LKB1; renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STK11-23H Recombinant Human STK11 protein, His-tagged E.coli His
Human STK11-240H Recombinant Human STK11 protein, GST/His-tagged E.coli GST/His
Human STK11-29853TH Recombinant Human STK11, His-tagged E.coli His
Human STK11-1410HCL Recombinant Human STK11 293 Cell Lysate HEK293 N/A
Human STK11-4447H Recombinant Human STK11 protein, His-SUMO-tagged E.coli His-SUMO 1-430aa
Human STK11-4048HF Active Recombinant Full Length Human STK11 Protein, GST-tagged Insect (sf21) GST 1-433
Mouse STK11-16132M Recombinant Mouse STK11 Protein Mammalian Cell His
Mouse STK11-2814M Recombinant Mouse STK11 Protein (1-433 aa), His-Myc-tagged Insect Cell His/Myc 1-433 aa
Mouse Stk11-668M Recombinant Mouse Stk11 Protein, His-tagged E.coli His Tyr49~Phe309
Mouse STK11-8801M Recombinant Mouse STK11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse STK11-8801M-B Recombinant Mouse STK11 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque STK11-4524R Recombinant Rhesus monkey STK11 Protein, His-tagged Mammalian Cell His
Rhesus Macaque STK11-4340R Recombinant Rhesus Macaque STK11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque STK11-4340R-B Recombinant Rhesus Macaque STK11 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish STK11-2563Z Recombinant Zebrafish STK11 Mammalian Cell His
Chicken STK11-3493C Recombinant Chicken STK11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • STK11 Related Articles
  • STK11 Related Signal Pathway

STK11 involved in several pathways and played different roles in them. We selected most pathways STK11 participated on our site, such as FoxO signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayARAF;MAPK9;MAP2K2;RAF1B;S1PR1;SGK1;TGFBR1B;PRKAB1;ATM
mTOR signaling pathwayCAB39L1;RRN3;PRKAA2;RPS6KA3A;RPS6KA6;PDPK1B;CAB39;PTENB;INS2
PIK-Akt signaling pathwayPPP2R5A;IL3;FGF8;NFKB1;HRAS;PPP2R2C;GNG2;TCL1B1;IGF1
AMPK signaling pathwayRAB11B;INSR;ULK1;RAB10;RPS6KB2;PFKM;MTOR;PIK3CA;FOXO3
Adipocytokine signaling pathwayPRKAB1;IKBKB;ACSL4B;PCK1;MAPK8A;RXRG;IRS4;G6PCA.1;IKBKG

STK11 has several biochemical functions, for example, ATP binding, LRR domain binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STK11 itself. We selected most functions STK11 had, and list some proteins which have the same functions with STK11. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACSL5;UBE2D2;TTF2;KIF23;ABCB6A;PRKCZ;EIF4A2;ADCK1;LRGUK
LRR domain bindingROBO1;KRAS;POLR2J;ZXDC;LRRFIP2;STK11
magnesium ion bindingTREX2;NT5C1AA;THTPA;RPS6KAL;ITPK1A;SNRK;ATP8B3;ENOPH1;ENO1
p53 bindingHTT;CHD8;RNF34;TP53BP1;TAF1;TRIM24;GSK3B;BCL2L12;SETD7
protein bindingFAM164A;C15orf23;MBNL1;NCF2;RABL2A;CBLN3;RAB1;NBL1;FBP2
protein complex bindingUGT1A6B;AKAP5;Ctsl;PROS1;PGAM5;TXN2;HCLS1;SLC25A3;PPARA
protein kinase activator activityTOM1L1;DUSP19;DBF4B;STRADA;AGAP2;STK11;DAXX;FAM58A;MT3
protein serine/threonine kinase activityALPK1;TSSK3;TAOK2;MAP3K8;PIM2;MAP3K2;RPS6KB2;PRKCB;ULK2

STK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of STK11.

STRADA; CAB39

Nakada, Y; Stewart, TG; et al. The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues. PLOS ONE 8:-(2013).
Zhong, DS; Liu, XJ; et al. LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. CANCER RESEARCH 68:7270-7277(2008).
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