"PARP1" Related Products

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Recombinant Human Poly (ADP-ribose) Polymerase 1

Cat. No.: PARP1-496H
Product Overview: Recombinant Human PARP1 protein was expressed inE.coliand purified by using conventional chromatography techniques, 39.6 kDa (354aa).
Description: PARP1 is a nuclear DNA-binding zinc finger protein which can exist as a homo- or hetero-dimer, and is strongly activated by DNA strand breaks. This protein involved in chromatin architecture and DNA metabolism, and participates in protein modification to enhance or repress transcription. PARP1 also plays a role in other cellular processes, including cell proliferation and differentiation. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADPribosyl)ation contributes to the efficient maintenance of genome integrity.
Source: E.coli.
Sequences Of Amino Acids: MKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK LSKRQIQAAY SILSEVQQAV SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KAEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE REGECQRYKP FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW.
Formulation: Liquid. In 20mM Tris buffer(pH 8.0) containing 10% glycerol 1mM DTT.
Purity: > 95% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Base excision repair
Gene Name: PARP1 poly (ADP-ribose) polymerase 1 [ Homo sapiens ]
Synonyms: PARP1; poly (ADP-ribose) polymerase 1; PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1; poly (ADP-ribose) polymerase family, member 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1; EC 2.4.2.30
Gene ID: 142
mRNA Refseq: NM_001618
Protein Refseq: NP_001609
MIM: 173870
UniProt ID: P09874
Chromosome Location: 1q41-q42
Function: DNA binding; NAD or NADH binding; NAD+ ADP-ribosyltransferase activity; identical protein binding; metal ion binding; protein N-terminus binding; protein binding; transcription factor binding; transferase activity, transferring glycosyl groups; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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