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PARP3

  • Official Full Name

    poly (ADP-ribose) polymerase family, member 3

  • Overview

    The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3 , ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Assay Kits
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • GST
  • HA
  • His
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PARP3-454H Active Recombinant Human PARP3, HA-tagged Sf21 Insect Cell HA
Human PARP3-59H Recombinant Human PARP-3 Sf9 Insect Cell N/A
Human PARP3-434H Recombinant Human Poly (ADP-ribose) Polymerase 3, GST-tagged Sf9 Insect Cell GST
Human PARP3-1533H Recombinant Human PARP3, GST-tagged E.coli GST C-term-300aa
Human PARP3-304H Recombinant Human PARP3 Protein, His & GST-tagged Insect Cell His/GST
Human PARP3-642H Recombinant Human PARP3 Protein, His-tagged Insect Cells His
Human PARP3-27634TH Recombinant Human PARP3, GST-tagged GST
Human PARP3-525HCL Recombinant Human PARP3 cell lysate Insect Cell N/A
Human PARP3-432H Recombinant Human PARP3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PARP3-2607H Recombinant Human PARP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Parp3-4679M Recombinant Mouse Parp3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish PARP3-10795Z Recombinant Zebrafish PARP3 Mammalian Cell His
Kit-1802 PARP3 Chemiluminescent Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PARP3 Related Research Area

PARP3 involved in several pathways and played different roles in them. We selected most pathways PARP3 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Base excision repairTDG.1;LIG3;APEX2;POLE3;NTHL1;POLE;OGG1;NEIL1;POLL

PARP3 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP3 itself. We selected most functions PARP3 had, and list some proteins which have the same functions with PARP3. You can find most of the proteins on our site.

Function Related Protein
NAD+ ADP-ribosyltransferase activityGIG2D;PARP1;GIG2G;TIPARP;PARP9;PARP14;GIG2I;GIG2P;GIG2K
catalytic activityTKTB;UQCRC2B;ZRANB3;HOGA1;ACSL3A;ETNPPL;LANCL1;PGAM1;AGXTA

PARP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP3.

MTHFD2; RPA3; HIST2H2BE; HIST2H3D

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does PARP3 interact with other proteins in the DNA repair pathway? 03/26/2023

PARP3 interacts with various proteins involved in DNA repair, forming complexes that coordinate the repair process.

How does the dysregulation of PARP3 relate to cancer development? 12/12/2019

Dysregulation of PARP3 can lead to genomic instability and impaired DNA repair, contributing to the development and progression of certain cancers.

Are there any diagnostic tools specifically detecting PARP3 activity? 03/09/2018

While there are research tools for studying PARP3 activity in the laboratory, clinical diagnostic tools targeting PARP3 are still in the early stages of development.

Is PARP3 involved in the regulation of immune responses? 02/05/2018

Emerging research suggests that PARP3 may play a role in immune regulation, and its modulation could potentially impact immune responses in diseases such as cancer.

Are there any clinical trials involving PARP3 inhibitors? 09/09/2016

Some clinical trials are exploring the efficacy and safety of PARP inhibitors, and their potential application in cancers where PARP3 is implicated.

Customer Reviews (3)

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Reviews
01/25/2023

    An additional advantage of selecting the PARP3 protein is the outstanding technical support offered by its manufacturer.

    09/09/2019

      Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.

      01/13/2016

        The combination of the protein's excellence and the manufacturer's exceptional technical support equips me with the necessary resources to overcome experimental obstacles and achieve groundbreaking results.

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