PARP3
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Official Full Name
poly (ADP-ribose) polymerase family, member 3
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Overview
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3 , ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Assay Kits
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21 Insect Cell
- Sf9 Insect Cell
- GST
- HA
- His
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PARP3 Related Research Area
PARP3 involved in several pathways and played different roles in them. We selected most pathways PARP3 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Base excision repair | TDG.1;LIG3;APEX2;POLE3;NTHL1;POLE;OGG1;NEIL1;POLL |
PARP3 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP3 itself. We selected most functions PARP3 had, and list some proteins which have the same functions with PARP3. You can find most of the proteins on our site.
Function | Related Protein |
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NAD+ ADP-ribosyltransferase activity | GIG2D;PARP1;GIG2G;TIPARP;PARP9;PARP14;GIG2I;GIG2P;GIG2K |
catalytic activity | TKTB;UQCRC2B;ZRANB3;HOGA1;ACSL3A;ETNPPL;LANCL1;PGAM1;AGXTA |
PARP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP3.
MTHFD2; RPA3; HIST2H2BE; HIST2H3D
- Q&As
- Reviews
Q&As (5)
Ask a questionPARP3 interacts with various proteins involved in DNA repair, forming complexes that coordinate the repair process.
Dysregulation of PARP3 can lead to genomic instability and impaired DNA repair, contributing to the development and progression of certain cancers.
While there are research tools for studying PARP3 activity in the laboratory, clinical diagnostic tools targeting PARP3 are still in the early stages of development.
Emerging research suggests that PARP3 may play a role in immune regulation, and its modulation could potentially impact immune responses in diseases such as cancer.
Some clinical trials are exploring the efficacy and safety of PARP inhibitors, and their potential application in cancers where PARP3 is implicated.
Customer Reviews (3)
Write a reviewAn additional advantage of selecting the PARP3 protein is the outstanding technical support offered by its manufacturer.
Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.
The combination of the protein's excellence and the manufacturer's exceptional technical support equips me with the necessary resources to overcome experimental obstacles and achieve groundbreaking results.
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