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PARP4

Official Full Name

poly (ADP-ribose) polymerase family, member 4
Overview

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.
Synonyms

PARP4; poly (ADP-ribose) polymerase family, member 4; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 1 , ADPRTL1; poly [ADP-ribose] polymerase 4; p193; VAULT3; von Willebrand factor A domain containing 5C; VPARP; VWA5C; PARP-related; H5;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PARP4-8198H	Recombinant Human PARP4 protein, His & T7-tagged	E.coli	His/T7	Val338~Thr609 (Accession # Q9UKK3)	Inquiry
Human	PARP4-2162H	Recombinant Human PARP4, His-tagged	E.coli	His		Inquiry
Human	PARP4-156H	Recombinant Human PARP4 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	PARP4-1291H	Recombinant Human PARP4 protein(607-1046aa), His-tagged	E. coli	N-His	607-1046aa	Inquiry
Chicken	PARP4-4049C	Recombinant Chicken PARP4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PARP4 Related Research Area

PARP4 involved in several pathways and played different roles in them. We selected most pathways PARP4 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Base excision repair	NEIL2;POLE4;PARP3;HMGB1A;mutY;nth;UNGA;LIG3;NEIL1

PARP4 has several biochemical functions, for example, DNA binding, NAD+ ADP-ribosyltransferase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP4 itself. We selected most functions PARP4 had, and list some proteins which have the same functions with PARP4. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZNF182;FOXG1;LIG1;JRKL;NFE2L2A;SCXB;NHEJ1;DACH1;RFXANK
NAD+ ADP-ribosyltransferase activity	TNKS;GIG2E;PARP9;GIG2H;ART3;GIG2D;GIG2F;ART5;TNKS2
enzyme binding	ECM1;MAT2B;CD4;U2AF2;ATXN10;ARRB2;HDAC1;PPP3CA;ANK1
protein binding	KRT17;ZFYVE16;ACOT7;CIAPIN1;TRIM63;KCP;PSMA3;SALL1;MOB3C

PARP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP4.

ORF; brrf1_ebvg; CCT6A; SMAD3; purL; flgE; trpE; q81m31_bacan; q81uh3_bacan; cof4; fimD7; flgH2; q9wmx2-pro_0000037548; 2_aha_camp; CLTC; Lgals3bp; SNW1

ADP-ribosyltransferases (ARTs)