Parp2
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Official Full Name
poly (ADP-ribose) polymerase 2
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Overview
This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. -
Synonyms
PARP2; poly (ADP-ribose) polymerase 2; ADP ribosyltransferase (NAD+; poly(ADP ribose) polymerase) like 2 , ADPRTL2, poly (ADP ribose) polymerase family, member 2; poly [ADP-ribose] polymerase 2; ADP ribosyltransferase like 2; ADPRT 2; ADPRT-2; ADPRT2; ADPRTL 2; ADPRTL 3; ADPRTL2; ADPRTL3; hPARP 2; hPARP-2; hPARP2; NAD(+) ADP ribosyltransferase 2; NAD(+) ADP-ribosyltransferase 2; pADPRT 2; pADPRT-2; pADPRT2; PARP 2; PARP-2; PARP2_HUMAN; Poly (ADP ribose) polymerase family member 2; Poly (ADP ribosyl) transferase like 2; Poly [ADP ribose] synthetase 2; Poly(ADP ribose) synthetase; Poly[ADP-ribose] synthase 2; OTTHUMP00000231900; OTTHUMP00000231902; OTTHUMP00000231904; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthetase 2; poly (ADP-ribosyl) transferase-like 2; poly (ADP-ribose) polymerase family, member 2; ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect cell
- Insect Cell
- Insect cells
- Mammalian Cell
- Sf21 Insect Cell
- Sf9 Insect Cell
- GST
- His
- Fc
- Avi
- N
- C
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
Parp2 involved in several pathways and played different roles in them. We selected most pathways Parp2 participated on our site, such as Base Excision Repair, DNA Damage Recognition in GG-NER, DNA Double-Strand Break Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with Parp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base Excision Repair | mutY;PNKP;POLD2;UNGA;PARP3;SMUG1;xthA;TDG;POLL |
| DNA Damage Recognition in GG-NER | GPS1;ACTL6A;NFRKB;DDB1;INO80B;YY1;COPS3;CETN2;COPS8 |
| DNA Double-Strand Break Repair | GEN1;WRN;RHNO1;RNF4;PPP4CA;BABAM1;TDP1;FUZ;KIAA0146 |
| DNA Repair | WRN;PPP4CB;PPP4CA;EYA2;ASCC1;BARD1;COPS4;YY1A;ALKBH2 |
| Dual Incision in GG-NER | DDB2;PARP2;CHD1L;DDB1 |
| Formation of Incision Complex in GG-NER | DDB1;DDB2;CETN2;CHD1L;PIAS3;PARP2;USP45;RNF111 |
| Global Genome Nucleotide Excision Repair (GG-NER) | TFPT;COPS2;COPS3;MCRS1;GPS1;COPS8;ACTR5;YY1;COPS7B |
Parp2 has several biochemical functions, for example, DNA binding, NAD+ ADP-ribosyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Parp2 itself. We selected most functions Parp2 had, and list some proteins which have the same functions with Parp2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF7;CRY2;POLA2;ZFP110;EPAS1B;SIX4A;THRAA;Ar;PIAS1 |
| NAD+ ADP-ribosyltransferase activity | GIG2O;GIG2I;GIG2F;TNKS;GIG2P;GIG2J;PARP3;TIPARP;SIRT6 |
| protein binding | SYT7;TLR2;SUPT5H;SSBP3;TARDBP;CD5;TRMT12;RAPGEF4;DPCD |
Parp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Parp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Parp2.
FKBP3; STAC; FAM168B; VPS37C; nad+; mgc:39545; NDUFA4; SYNJ2; DFFB; MYO1D; RTN3; IFNA16; PCCA; HMGN2; HIST1H1E; CD58; PTMS
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