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Parp2

  • Official Full Name

    poly (ADP-ribose) polymerase 2

  • Overview

    This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.
  • Synonyms

    PARP2; poly (ADP-ribose) polymerase 2; ADP ribosyltransferase (NAD+; poly(ADP ribose) polymerase) like 2 , ADPRTL2, poly (ADP ribose) polymerase family, member 2; poly [ADP-ribose] polymerase 2; ADP ribosyltransferase like 2; ADPRT 2; ADPRT-2; ADPRT2; ADPRTL 2; ADPRTL 3; ADPRTL2; ADPRTL3; hPARP 2; hPARP-2; hPARP2; NAD(+) ADP ribosyltransferase 2; NAD(+) ADP-ribosyltransferase 2; pADPRT 2; pADPRT-2; pADPRT2; PARP 2; PARP-2; PARP2_HUMAN; Poly (ADP ribose) polymerase family member 2; Poly (ADP ribosyl) transferase like 2; Poly [ADP ribose] synthetase 2; Poly(ADP ribose) synthetase; Poly[ADP-ribose] synthase 2; OTTHUMP00000231900; OTTHUMP00000231902; OTTHUMP00000231904; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthetase 2; poly (ADP-ribosyl) transferase-like 2; poly (ADP-ribose) polymerase family, member 2; ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PARP2-157H Recombinant Human PARP2 Protein, GST-tagged Insect Cell GST 2-583
Human PARP2-433H Recombinant Human Poly (ADP-ribose) Polymerase 2, GST-tagged Sf9 Insect Cell GST
Human PARP2-7559H Recombinant Human PARP2, His-tagged E.coli His 233-583aa
Human PARP2-006H Recombinant Human PARP2 Protein, GST-tagged Insect cell GST 2-583
Human PARP2-3858H Recombinant Human PARP2 Protein (Ser223-Trp583), N-His tagged E.coli N-His Ser223-Trp583
Mouse Parp2-453M Active Recombinant Mouse Parp2, His-tagged Sf21 Insect Cell His
Mouse Parp2-613M Recombinant Mouse Poly (ADP-ribose) Polymerase Family, Member 2 Sf9 Insect Cell N/A
Mouse Parp2-641M Recombinant Mouse Parp2, His-tagged Sf21 Insect Cell His
Mouse PARP2-12373M Recombinant Mouse PARP2 Protein Mammalian Cell His
Mouse PARP2-6506M-B Recombinant Mouse PARP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse PARP2-6506M Recombinant Mouse PARP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PARP2-3308R Recombinant Rhesus monkey PARP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PARP2-3126R Recombinant Rhesus Macaque PARP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PARP2-3126R-B Recombinant Rhesus Macaque PARP2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PARP2-8014Z Recombinant Zebrafish PARP2 Mammalian Cell His
Kit-1799 PARP2 Chemiluminescent Assay Kit N/A
Kit-1800 PARP2 Colorimetric Assay Kit N/A
Kit-1801 PARP2 Homogeneous Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Parp2 involved in several pathways and played different roles in them. We selected most pathways Parp2 participated on our site, such as Base Excision Repair, DNA Damage Recognition in GG-NER, DNA Double-Strand Break Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with Parp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Base Excision RepairUNGA;NEIL1;POLE4;PARP3;PARP2;MUTYH;HMGB1A;POLD2;PARP4
DNA Damage Recognition in GG-NERCOPS6;INO80;YY1A;NFRKB;YY1;CETN2;INO80C;INO80B;GPS1
DNA Double-Strand Break RepairRAD50;THRSP;TDP2B;PPP4R2B;CHEK1;BABAM1;RNF4;EYA4;CLSPN
DNA RepairMCRS1;ASCC3;CETN2;USP45;BRCC3;TOPBP1;UIMC1;SPRTN;INO80
Dual Incision in GG-NERDDB1;PARP2;CHD1L;DDB2
Formation of Incision Complex in GG-NERDDB1;CETN2;CHD1L;USP45;PARP2;RNF111;DDB2;PIAS3
Global Genome Nucleotide Excision Repair (GG-NER)PIAS3;COPS2;COPS6;INO80C;CHD1L;PARP2;GPS1;MCRS1;INO80B

Parp2 has several biochemical functions, for example, DNA binding, NAD+ ADP-ribosyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Parp2 itself. We selected most functions Parp2 had, and list some proteins which have the same functions with Parp2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPDCD2;MTERFD1;THAP5;PCBP2;POLR2I;SOX21;ZFY1;ZFP422;ZNF729
NAD+ ADP-ribosyltransferase activityPARP16;ART5;PARP14;PARP2;GIG2J;SIRT6;ART3;GIG2H;GIG2F
protein bindingFGF3;HSPA13;SERPING1;CD47;NPDC1;DDX23;GZMM;FAM134B;ZFP746

Parp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Parp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Parp2.

FKBP3; STAC; FAM168B; VPS37C; nad+; mgc:39545; NDUFA4; SYNJ2; DFFB; MYO1D; RTN3; IFNA16; PCCA; HMGN2; HIST1H1E; CD58; PTMS

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