PARP1

  • Official Full Name

    poly (ADP-ribose) polymerase 1

  • Overview

    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
  • Synonyms

    PARP1; poly (ADP-ribose) polymerase 1; PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 1; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mamanlian cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf21 insect cells
  • Sf9 Insect Cell
  • C
  • His
  • Myc
  • DDK
  • Flag
  • FLAG
  • Avi
  • GST
  • HA
  • His (Fc)
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PARP1-451H Active Recombinant Human PARP1, HA-tagged Sf21 Insect Cell HA
Human PARP1-58H Active Recombinant Human PARP-1 Sf9 Insect Cell N/A
Human PARP1-444H Active Recombinant Human PARP1, MYC-tagged Sf21 Insect Cell MYC
Human PARP1-03H Active Recombinant Human PARP1 Protein, MYC/His-Tagged Sf21 insect cells
Human PARP1-496H Recombinant Human Poly (ADP-ribose) Polymerase 1 E.coli N/A
Human PARP1-1658H Recombinant Human Poly (ADP-ribose) Polymerase 1 Insect Cell N/A
Human PARP1-1530H Recombinant Human PARP1, His-tagged E.coli His 1-327aa
Human PARP1-640H Recombinant Human PARP1 Protein, His-tagged Insect Cell His
Human PARP1-430H Recombinant Human Poly (ADP-ribose) Polymerase 1, GST-tagged Sf9 Insect Cell GST
Human PARP1-27540TH Recombinant Human PARP1 N/A
Human PARP1-30787TH Recombinant Human PARP1 N/A
Human PARP1-337H Recombinant Human PARP1 Mammalian Cell His
Human PARP1-101H Recombinant Human PARP1 Protein, DDK-tagged Insect Cell DDK
Human PARP1-156H Recombinant Human PARP1 Protein, His-tagged Insect Cell His Met 1-Trp 1014
Human PARP1-710HCL Recombinant Human PARP1 cell lysate Insect Cell N/A
Human PARP1-01H Recombinant Human PARP1 protein, His-tagged E.coli His
Human ZNF101-434H Recombinant Human PARP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PARP1-1531H Recombinant Human PARP1 Protein, His-tagged E.coli His Asp788~Trp1014
Human PARP1-010H Active Recombinant Human PARP1 Protein, GST-tagged Insect cell GST 2-1041
Human PARP1-2615H Recombinant Human PARP1 protein(61-370 aa), C-His-tagged E.coli C-His 61-370 aa
Human PARP1-075H Recombinant Human PARP1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PARP1-650HAF555 Recombinant Human PARP1 Protein, His-tagged, Alexa Fluor 555 conjugated Insect Cells His 1024
Human PARP1-650HAF488 Recombinant Human PARP1 Protein, His-tagged, Alexa Fluor 488 conjugated Insect Cells His 1024
Human PARP1-650HAF647 Recombinant Human PARP1 Protein, His-tagged, Alexa Fluor 647 conjugated Insect Cells His 1024
Human PARP1-59H Recombinant Human PARP1 Protein E.coli
Human PARP1-650HF Recombinant Human PARP1 Protein, His-tagged, FITC conjugated Insect Cells His 1024
Human PARP1-88H Recombinant Human PARP1 Protein, His-tagged E.coli His
Human PARP1-7683HFL Recombinant Full Length Human PARP1, Flag-tagged Mamanlian cells Flag
Human PARP1-431H Recombinant Human PARP1 Protein, FLAG/Avi-tagged Insect Cell FLAG/Avi
Human PARP1-3796H-B Recombinant Human PARP1 Protein Pre-coupled Magnetic Beads HEK293
Human PARP1-301634H Recombinant Human PARP1 protein, GST-tagged E.coli GST Pro666-Trp1014
Human PARP1-3796H Recombinant Human PARP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PARP1-4026H Recombinant Human PARP1 Protein (Thr373-Glu540), N-His tagged E.coli N-His Thr373-Glu540
Human PARP1-5332H Recombinant Human PARP1 protein(324-541aa), His-GST-tagged E.coli N-His-GST 324-541aa
Mouse Parp1-2535M Recombinant Mouse Parp1, His tagged Insect Cell His Met 1-Trp 1014
Mouse Parp1-357M Recombinant Mouse Parp1 Protein, His-tagged E.coli His Asp788~Trp1014
Mouse Parp1-358M Recombinant Mouse Parp1 Protein, His-tagged E.coli His Lys661~Pro881
Mouse PARP1-514MCL Recombinant Mouse PARP1 cell lysate Insect Cell N/A
Mouse Parp1-2535MF Recombinant Mouse Parp1 Protein, His-tagged, FITC conjugated Insect Cells His 1033
Mouse Parp1-2535MAF488 Recombinant Mouse Parp1 Protein, His-tagged, Alexa Fluor 488 conjugated Insect Cells His 1033
Mouse Parp1-2535MAF647 Recombinant Mouse Parp1 Protein, His-tagged, Alexa Fluor 647 conjugated Insect Cells His 1033
Mouse Parp1-2535MAF555 Recombinant Mouse Parp1 Protein, His-tagged, Alexa Fluor 555 conjugated Insect Cells His 1033
Mouse Parp1-548M Recombinant Mouse Parp1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat PARP1-4276R Recombinant Rat PARP1 Protein Mammalian Cell His
Rat PARP1-3938R-B Recombinant Rat PARP1 Protein Pre-coupled Magnetic Beads HEK293
Rat PARP1-3938R Recombinant Rat PARP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PARP1-4040Z Recombinant Zebrafish PARP1 Mammalian Cell His
Zebrafish parp1-1344D Recombinant Zebrafish parp1 Protein (Ser120-Trp240), N-His tagged E.coli N-His Ser120-Trp240
Chicken PARP1-6815C Recombinant Chicken PARP1 Mammalian Cell His
Kit-1792 PARP1 Chemiluminescent Assay Kit N/A
Kit-1793 PARP1 Chemiluminescent Assay Kit (384-well) N/A
Kit-1794 PARP1 Colorimetric Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PARP1 involved in several pathways and played different roles in them. We selected most pathways PARP1 participated on our site, such as Base Excision Repair, Caspase cascade in apoptosis, Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Base Excision RepairLIG1;FEN1;NEIL2;POLD1;xthA;POLL;MUTYH;MPG;HMGB1A
Caspase cascade in apoptosisTOP1;GAS2;CRADD;PARP1;CASP2;ACTA1;NUMA1;SATB1;LMNB1
Corticotropin-releasing hormoneCRHR1;PARP1;ADRBK2;JUNB;TRIM28;CRH;TCF4;CASP12;KRT14
DNA Damage Recognition in GG-NERACTR5;COPS6;GPS1;CETN2;YY1A;COPS3;COPS2;DDB2;ACTL6A
DNA Double-Strand Break RepairWRN;BARD1;BABAM1;RNF168;PARP2;HTATIP;UBE2V2;CLSPN;KDM4B
DNA RepairINO80;CHEK1;MAD2L2;KDM4A;POLD3;EME1;SMARCA5;UBE2V2;CHEK2
Downregulation of SMAD2/3:SMAD4 transcriptional activitySMAD3B;USP9X;TRIM33;SKILB;SKIB;PARP1;USP9;SKIA;RNF111

PARP1 has several biochemical functions, for example, DNA binding, NAD binding, NAD+ ADP-ribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP1 itself. We selected most functions PARP1 had, and list some proteins which have the same functions with PARP1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingSOX8;ZFP628;ZFP292;REPIN1;CRY2;HOXC10A;MUS81;IRF3;ZBED1
NAD bindingHADHA;CYB5R3;GRHPRA;ADH1;TESCA;GRHPRB;NNT;IDH1;HSD3B5
NAD+ ADP-ribosyltransferase activityPARP14;GIG2I;PARP3;TIPARP;ART5;CHAT2;ART3;CHAT1;SIRT6
R-SMAD bindingSMAD6;SMAD3;SMURF1;PPM1A;PAX6;CTNNB1;C18orf1;SMAD4;ZC3H3
chromatin bindingSIX1;HMGB2B;GATA3;MSL1A;HOXC13;ZEB1;BEND6;MBD1;HMGXB4A
enzyme bindingSCARB2;CYP2E1;A2M;DDC;HDAC1;HIST1H2AL;RPS2;PRKCH;PRMT1
identical protein bindingUSP15;PAFAH1B3;NIF3L1;VWA1;LEPR;KHDC1B;DYNLRB1;HSD17B10;NFKBIA
poly(A) RNA bindingPTPN1;ZFP36;DDX46;SRP19;EIF3D;NXF2;HIST1H4M;EIF4H;MTHFSD
protein N-terminus bindingSERPINB1A;PPP1CC;ERCC4;YWHAQ;RPS21;RND2;VWF;ACTN4;SMARCC1
protein bindingRHPN1;PA2G4;NUDT14;TBC1D23;POLR1B;TAOK1;DSN1;RBKS;FOXO3
protein kinase bindingSOCS1;B4GALT1;ZBTB4;CHRNA7;MAP3K13;PPP1R15A;SPDYB;RELA;CDH2
transcription factor bindingNKX3;ZFPM1;GPX3;GATA3;ATF7;PAX6;KAT8;HDAC1;NAB2
zinc ion bindingAKAP8;HIF1AN;TIMM9;GATAD2AB;PYGO2;ENPP1;LTA4H;PHRF1;LMX1BA

PARP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP1.

XRCC5; TP53; WRN

Research Area

Related articles

Beck, C; Robert, I; et al. Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3. EXPERIMENTAL CELL RESEARCH 329:18-25(2014).
Kim, J; Lim, W; et al. Photodynamic therapy (PDT) resistance by PARP1 regulation on PDT-induced apoptosis with autophagy in head and neck cancer cells. JOURNAL OF ORAL PATHOLOGY & MEDICINE 43:675-684(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Does PARP1 protein cause cells to die in time? 12/30/2022

Yes, overactivation of the PARP1 protein can lead to apoptosis or necrosis of cells, which may be exploited in the treatment of certain diseases.

How is the PARP1 protein involved in DNA repair? 02/25/2022

The PARP1 protein can repair DNA damage by attaching ADP-ribose groups to damaged DNA strands and recruiting other repair proteins.

What are the other regulatory mechanisms of PARP1 protein in DNA damage repair? 01/07/2022

In addition to PARP1's involvement in direct DNA repair, it can also modulate the selection of repair pathways and initiate other DNA damage sensing mechanisms.

What is the potential of PARP1 protein in tumor immunotherapy? 09/29/2019

Some studies have proposed that the interaction of PARP1 protein with DNA damage in tumor immunotherapy may affect the efficacy of immunotherapy.

Is PARP1 protein involved in cell cycle regulation? 05/19/2019

Yes, the PARP1 protein is involved in the normal regulation of the cell cycle, especially G1/S and G2/M switching during DNA damage.

What are the effects of overactivation of PARP1 protein on cells? 01/07/2019

Overactivation of PARP1 depletes energy stores such as NAD+ and ATP and leads to apoptosis, or cell death.

Customer Reviews (3)

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Reviews
06/01/2020

    This range of applications of PARP1 is breathtaking, and it can play an important role in any field.

    12/02/2019

      This short half-life and high clearance of PARP1 make it have greater potential in the treatment of tumors, infections and other diseases, and it is expected to become a new generation of therapeutic drugs.

      03/18/2019

        The purity and bioactivity of PARP1 make it a valuable resource for scientific research.

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