"STK10" Related Products


Recombinant Human Serine/Threonine Kinase 10, His-tagged

Cat. No. : STK10-555H
Product Overview : Recombinant human LOK was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW=43.2 kDa.
Description : LOK is a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. LOK can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. LOK can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. MEKK1 and LOK have opposing roles in regulating the enhancer element of the IL-2 gene during T-cell activation. While MEKK1 is responsible for the CD28 signalling pathway that activates the CD28 response element, co-expression of LOK attenuates these effects.
Source : Sf9 insect cells.
Purity : 60%.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 1 mM DTT.
Stability : >6 months at –80°C.
Gene Name : STK10 serine/threonine kinase 10 [ Homo sapiens ]
Synonyms : STK10; serine/threonine kinase 10; LOK; PRO2729; lymphocyte-oriented kinase; EC
Gene ID : 6793
mRNA Refseq : NM_005990
Protein Refseq : NP_005981
MIM : 603919
UniProt ID : O94804
Chromosome Location : 5q35.1
Function : ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity

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