Recombinant Human Serine/Threonine Kinase 10, His-tagged
Cat.No. : | STK10-555H |
Product Overview : | Recombinant human LOK was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW=43.2 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | STK10-555H |
Description : | LOK is a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. LOK can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. LOK can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. MEKK1 and LOK have opposing roles in regulating the enhancer element of the IL-2 gene during T-cell activation. While MEKK1 is responsible for the CD28 signalling pathway that activates the CD28 response element, co-expression of LOK attenuates these effects. |
Source : | Sf9 insect cells. |
Purity : | 60%. |
Application : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 1 mM DTT. |
Stability : | >6 months at –80°C. |
Gene Name : | STK10 serine/threonine kinase 10 [ Homo sapiens ] |
Synonyms : | STK10; serine/threonine kinase 10; LOK; PRO2729; lymphocyte-oriented kinase; EC 2.7.11.1 |
Gene ID : | 6793 |
mRNA Refseq : | NM_005990 |
Protein Refseq : | NP_005981 |
MIM : | 603919 |
UniProt ID : | O94804 |
Chromosome Location : | 5q35.1 |
Function : | ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity |
Products Types
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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