Recombinant Canine NRG1, Fc tagged

• Cat.No.: NRG1-172C
• Product Overview: Recombinant Canine NRG1 isoform alpha (XP_858147.1) (Ser176-Lys240), fused with the Fc region of mouse IgG1 at the N-terminus, was produced in Human Cells.

Specification

• Source: Human Cells
• Species: Canine
• Tag: Fc
• Predicted N Terminal: Asp
• Form: Lyophilized from sterile PBS, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
• Molecular Mass: The recombinant canine NRG1 is a disulfide-linked homodimer. The reduced monomer comprises 301 amino acids and has a predicted molecular mass of 34 kDa. The apparent molecular mass of the protein is approximately 37 and 34 kDa in SDS-PAGE under reducing c
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: (92.0+7.0) % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70oC.
• Storage: Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: NRG1 neuregulin 1 [ Canis lupus familiaris (dog) ]
• Official Symbol: NRG1
• Gene ID: 482861
• mRNA Refseq: XM_852768
• Protein Refseq: XP_857861
• Chromosome Location: 16

Reviews

08/12/2022

Excellent results, very consistent.

01/27/2021

Worked great in assays.

01/02/2019

Great product, very reliable.

Q&As

How is NRG1 implicated in neural development and synaptic plasticity?

NRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.

What role does NRG1 play in cardiac development and function?

In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.

Are there any associations between NRG1 mutations or dysregulation and diseases?

Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.

What are the therapeutic implications of targeting NRG1 in various diseases?

Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.

Are there different isoforms of NRG1, and how do they differ in function?

Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.

How does NRG1 interact with its receptor, and what are the downstream signaling pathways activated?

NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.

What is the primary biological function of the NRG1 protein?

NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.