Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

NRG3

Official Full Name

neuregulin 3
Overview

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
Synonyms

NRG3; neuregulin 3; pro-neuregulin-3, membrane-bound isoform; neuregulin 3 variant 1; neuregulin 3 variant 3; neuregulin 3 variant 4; neuregulin 3 variant 5; neuregulin 3 variant 6; neuregulin 3 variant 7; neuregulin 3 variant 8; neuregulin 3 variant 9; n;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Homo sapiens (Human)
Human
Mus musculus (Mouse)

Source

E.coli
E.coli expression system
HEK293

Tag

C
His
Fc
His|SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NRG3-762H	Recombinant Human NRG3 Protein, Fc-tagged	HEK293	Fc		Inquiry
Human	NRG3-763H	Recombinant Human NRG3 protein(Glu282-Pro342), His-tagged	HEK293	C-His	Glu282-Pro342	Inquiry
Human	NRG3-3697HCL	Recombinant Human NRG3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NRG3-1791H	Recombinant Human NRG3 Protein (1-360 aa), His-SUMO-tagged	E.coli	His/SUMO	1-360 aa	Inquiry
Homo sapiens (Human)	RFL11233HF	Recombinant Full Length Human Pro-Neuregulin-3, Membrane-Bound Isoform(Nrg3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-720)	Inquiry
Mus musculus (Mouse)	RFL15481MF	Recombinant Full Length Mouse Pro-Neuregulin-3, Membrane-Bound Isoform(Nrg3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-713)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
NRG3 Related Articles
NRG3 Related Research Area

NRG3 involved in several pathways and played different roles in them. We selected most pathways NRG3 participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ARMS-mediated activation	DLG4;JAK1;DUSP4;SPRED3;KBTBD7;RASGEF1A;EGF;NRG4;DUSP6
Adaptive Immune System	FAM49BA;MGC174857;RNF144B;RNF182;KIF3C;IGHM;ITK;MAPKAP1;KIR2DS2
Axon guidance	EPHA2;ARPC2;CDK5;ADAM10;DUSP10;KALRNB;EFNA3B;SDCBP;PAK3
Constitutive Signaling by Aberrant PI3K in Cancer	NRG3;FRS2;TRAT1;EGF;NRG4;HBEGF;KLB
Cytokine Signaling in Immune system	NRG4;DUSP10;NOD1;EDA;TRIM5;TRIM46;CRKL;DUSP4;SAMHD1
DAP12 interactions	PEA15;PAQR3B;DUSP9;TREM1;GRAP2A;FRS2B;IL17RD;CSF2RB;SPTB
DAP12 signaling	SPNA1;GRAP2A;DAB2IPB;SPRED2;NRG2A;PAQR3B;CSF2RB;FGF20A;PHB
Developmental Biology	FRS3;SCN2B;FOXH1;RGMA;LGI2;CAP1;RNF8;SEMA4D;DUSP5

NRG3 has several biochemical functions, for example, chemorepellent activity, growth factor activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRG3 itself. We selected most functions NRG3 had, and list some proteins which have the same functions with NRG3. You can find most of the proteins on our site.

Function	Related Protein
chemorepellent activity	APOA1;SEMA3FA;SEMA3GA;SEMA3BL;SEMA6D;FLRT3;NRG1;EPHA7;SEMA3GB
growth factor activity	GDF5;NDP;MSTNA;FGF2;ANGPTL3;NTF3;Kitl;BMP8B;F2
receptor binding	RSPO1;ARPP19;HACL1;NPFFL;F7;SRI;MSTN;PTK6B;NRG2A
receptor tyrosine kinase binding	ELMO2;SHC3;GAS6;NCK1;CPNE3;FLT3LG;GNB2L1;SHC4;ANGPT2
transmembrane receptor protein tyrosine kinase activator activity	NRG1;EGF;ANGPT4;EFNA5;NRG3;GREM1

NRG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRG3.

Mahtouk, K; Moreaux, J; et al. Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays. BMC CANCER 10:-(2010).

Dunn, M; Sinha, P; et al. Co-expression of neuregulins 1, 2, 3 and 4 in human breast cancer. JOURNAL OF PATHOLOGY 203:672-680(2004).

Diabetic Peripheral Neuropathy