Recombinant Human NRG1 Protein (Ser20-Lys241), Animal-free, Carrier-free
Cat.No. : | NRG1-142H |
Product Overview : | Recombinant Human NRG1 Protein (Ser20-Lys241) without tag was expressed in E. coli and Animal-free as well as Carrier-free. |
- Specification
- Gene Information
- Related Products
Description : | Neuregulin-1 (NRG-1, also called heuregulin1 or neu differentiation factor) is a glycoprotein that belongs to the neuregulins family. Structurally, Neuregulin-1 harbors tissue-specific N terminal sequence, followed by immunoglobulin-like (Ig-like) domains, an EGF-like domain, a transmembrane domain, and a cytoplasmic domain. Neuregulin-1 exerts its actions upon engagement of its EGF-like domain to the extracellular binding region of HER RTK family members (EGFR, HER2, HER3, and HER4), subsequently leading to receptor dimerization which activates a variety of signal pathways such as MAPK-ERK and PI3K-AKT pathways. These signal cascades are essential for regulating cardiac development, neuronal differentiation, neuromuscular synapses formation, and stem cell proliferation. |
Source : | E. coli |
Species : | Human |
Tag : | Tag Free |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 24.29 kDa. The protein migrates as 28-30 kDa under reducing condition (SDS-PAGE analysis). |
Protein Length : | Ser20-Lys241 |
Endotoxin : | < 1 EU/μg of the protein by the LAL method. |
Purity : | >95% as determined by SDS-PAGE analysis. |
Storage : | This product is stable after storage at: -20 centigrade for 12 months in lyophilized state from date of receipt. -20 or -80 centigrade for 1 month under sterile conditions after reconstitution. Avoid repeated freeze/thaw cycles. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Reconstitution : | It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved. |
Shipping : | The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage. |
Gene Name : | NRG1 neuregulin 1 [ Homo sapiens (human) ] |
Official Symbol : | NRG1 |
Synonyms : | NRG1; neuregulin 1; HGL; pro-neuregulin-1, membrane-bound isoform; GGF; HRG; NDF; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator); ARIA; GGF2; HRG1; HRGA; SMDF; MST131; |
Gene ID : | 3084 |
mRNA Refseq : | NM_001159995 |
Protein Refseq : | NP_001153467 |
MIM : | 142445 |
UniProt ID : | Q02297 |
Products Types
◆ Recombinant Protein | ||
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NRG1-215H | Recombinant Human NRG1-β Protein | +Inquiry |
NRG1-29H | Recombinant Human/Bovine/Porcine NRG1 Protein | +Inquiry |
NRG1-3227H | Recombinant Human NRG1 protein(Ser2-Lys246), Biotinylated | +Inquiry |
NRG1-141H | Active Recombinant Human NRG1 Protein (Ser177-Glu241), C-His tagged, Animal-free, Carrier-free | +Inquiry |
◆ Lysates | ||
NRG1-836CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
NRG1-1599HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
NRG1-001CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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