NRG1
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Official Full Name
neuregulin 1
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Overview
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009] -
Synonyms
NRG1; neuregulin 1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; pro-neuregulin-1, membrane-bound isoform; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator);
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canine
- Chicken
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Hordeum Vulgare
- Human Cell
- Insects cells
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Fc
- His
- Avi
- GST
- HQ
- mFc
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
NRG1 involved in several pathways and played different roles in them. We selected most pathways NRG1 participated on our site, such as ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | NCK2B;MAP2K7;RPS6KB1B;CBLB;ERBB3A;ERBB4A;MAPK3;TGFA;RAF1A |
NRG1 has several biochemical functions, for example, ErbB-2 class receptor binding, ErbB-3 class receptor binding, chemorepellent activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NRG1 itself. We selected most functions NRG1 had, and list some proteins which have the same functions with NRG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ErbB-2 class receptor binding | NRG1;MUC4;CDK5 |
| ErbB-3 class receptor binding | PIK3R1;ERBB2;NRG1;CDK5 |
| chemorepellent activity | SEMA3AA;SEMA3C;SEMA3B;SEMA6E;SEMA4E;SEMA4C;SEMA4D;FLRT2;EFNA5 |
| cytokine activity | FGF2;NDP;IFNB1;INHA;IL8L2;IFNPHI2;GPI1;IFNA7;IL4 |
| growth factor activity | GDF9;GDF6;CSF1B;LIF;INHBAB;FBRS;BMP10;PPBP;CNTF |
| protein binding | SULT1A1;NDC80;ILF2;MC4R;KBTBD6;CEP72;EML2;HIST1H4L;GNAS |
| protein tyrosine kinase activator activity | CD24;ABI1A;ERCC6;ABI1B;PAK2;AFAP1L2;ERBB3;ABI3A;GHRL |
| receptor binding | NRG2;DECR2;ZAP70;FGG;REN;PAOX;POU2F1;F2;GSDMA2 |
| receptor tyrosine kinase binding | GNB2L1;PCNA;LRP4;HYAL2;FNTA;ANXA5;ANGPT2;PTPN2;NCK1 |
| transcription cofactor activity | THRAP3;MED17;TMF1;TADA2A;KAT2B;PRKCBP1L;IRF3;MSX2;AIRE |
| transmembrane receptor protein tyrosine kinase activator activity | ANGPT4;NRG3;NRG1;EGF;EFNA5;GREM1 |
NRG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRG1.
EGFR; dnaE; q7cgr6_yerpe; CDC5L
Research Area
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Q&As (7)
Ask a questionNRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.
In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.
Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.
Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.
Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.
NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.
NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.
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