NRG1 Protein

September 27-30, 2022

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NRG1

Home / Products / NRG1

NRG1

Official Full Name neuregulin 1
Background The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009]
Synonyms NRG1; neuregulin 1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; pro-neuregulin-1, membrane-bound isoform; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator);
    • Species :
    • Canine
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rattus norvegicus (Rat)
    • Zebrafish
    • Source :
    • E.coli
    • E.coli expression system
    • HEK293
    • Hordeum Vulgare
    • Human Cell
    • Insects cells
    • Mammalian Cell
    • Mammalian cells
    • Sf21 Insect Cell
    • Tag :
    • Fc
    • His
    • GST
    • HQ
    • N/A
    • N-His
    • N-His&GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NRG1-06H Recombinant Human NRG1 protein E.coli N/A
    Human NRG1-10H Recombinant Human NRG1, Fc tagged Human Cell Fc
    Human NRG1-1280H Recombinant Human Neuregulin 1, HQ-tagged Hordeum Vulgare HQ
    Human NRG1-16H Recombinant Human NRG1 protein E.coli N/A
    Human NRG1-183H Recombinant Human NRG1 E.coli N/A
    Human NRG1-239H Recombinant Human NRG1 Protein, Fc-tagged HEK293 Fc
    Human NRG1-240H Recombinant Human NRG1 Protein, His-tagged HEK293 His
    Human NRG1-2675H Recombinant Human Neuregulin 1 E.coli N/A
    Human NRG1-27577TH Recombinant Human NRG1, His-tagged His
    Human NRG1-325H Recombinant Human NRG1 Protein, Fc-tagged HEK293 Fc
    Human NRG1-678H Recombinant Human NRG1 protein E.coli N/A
    Human NRG1-679H Recombinant Human NRG1 Protein, His-tagged Sf21 Insect Cell His
    Human NRG1-709H Recombinant Human NRG1 Protein, His-tagged E.coli His
    Human NRG1-710H Recombinant Human NRG1 Protein, His-tagged E.coli His
    Human NRG1-7320H Recombinant Human NRG1, Fc tagged Human Cell Fc
    Human NRG1-7321H Recombinant Human NRG1, None tagged Human Cell N/A
    Rat Nrg1-1892R Recombinant Rat Nrg1 protein, His-tagged E.coli His
    Canine NRG1-1049C Recombinant Canine NRG1 Protein, His-tagged HEK293 His
    Canine NRG1-1050C Recombinant Canine NRG1 Protein HEK293 N/A
    Canine NRG1-154C Recombinant Canine NRG1, Fc tagged Human Cell His
    Canine NRG1-171C Recombinant Canine NRG1, His tagged Human Cell Fc/His
    Canine NRG1-172C Recombinant Canine NRG1, Fc tagged Human Cell His
    Canine NRG1-178C Recombinant Canine NRG1 Human Cell N/A
    Chicken NRG1-5693C Recombinant Chicken NRG1 Mammalian Cell His
    Zebrafish NRG1-4015Z Recombinant Zebrafish NRG1 Mammalian Cell His
    Human NRG1-029H Recombinant Human Neuregulin 1 E.coli N/A
    Human NRG1-1591HCL Recombinant Human NRG1 cell lysate Human Cell N/A
    Human NRG1-1592HCL Recombinant Human NRG1 cell lysate Human Cell N/A
    Human NRG1-1599HCL Recombinant Human NRG1 cell lysate Human Cell N/A
    Human NRG1-1675HCL Recombinant Human NRG1 cell lysate Human Cell N/A
    Canine NRG1-001CCL Recombinant Canine NRG1 cell lysate Human Cell N/A
    Canine NRG1-836CCL Recombinant Canine NRG1 cell lysate Human Cell N/A
    Human NRG1-140HG GMP Recombinant Human NRG1 protein E.coli N/A
    Rat Nrg1-1860R Recombinant Rat Nrg1 Protein, His&GST-tagged E.coli N-His&GST
    Human NRG1-2510H Recombinant Human NRG1 Protein, His-tagged E.coli N-His
    Rattus norvegicus (Rat) RFL14495RF Recombinant Full Length Rat Pro-Neuregulin-1, Membrane-Bound Isoform(Nrg1) Protein, His-Tagged E.coli expression system His
    Human NRG1-01H Recombinant Human NRG1 Protein, His-tagged Insects cells His
    Human NRG1-139HG GMP Recombinant Human NRG1 Protein E.coli N/A
    Mouse Nrg1-1755M Recombinant Mouse Nrg1 protein, His & GST-tagged E.coli His/GST
    Mouse NRG1-23M Recombinant Mouse Nrg1 Protein, His-tagged Mammalian cells His

    NRG1 involved in several pathways and played different roles in them. We selected most pathways NRG1 participated on our site, such as ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway RAF1A; NRG2B; BRAF; MAP2K4A; HRAS; PIK3CG; ARAF; TGFA; PRKCB; SHC1

    NRG1 has several biochemical functions, for example, ErbB-2 class receptor binding, ErbB-3 class receptor binding, chemorepellent activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NRG1 itself. We selected most functions NRG1 had, and list some proteins which have the same functions with NRG1. You can find most of the proteins on our site.

    Function Related Protein
    ErbB-2 class receptor binding MUC4; CDK5; NRG1
    ErbB-3 class receptor binding NRG1; ERBB2; PIK3R1; CDK5
    chemorepellent activity SEMA3BL; SEMA6B; SEMA3G; SEMA4D; SEMA3AA; NRG3; SEMA4C; SEMA4A; SEMA5B; SEMA3D
    cytokine activity NAMPT; GM13278; GM13287; INHBE; IFNW1; IL15L; TNFSF10; GDF10B; NODAL; GDF3
    growth factor activity FGF14; BMP8B; GDF3; HBEGF; INHBC; FGF20A; PDGFC; NUDT6; FGF20B; FGF1
    protein binding PKN1; MARK4; CGGBP1; LGALS14; ORAI3; KCNE3; CSRP3; KREMEN1; FBP2; PFKFB2
    protein tyrosine kinase activator activity ABI1B; ERBB3; ABI1; CD24; ABI3A; GAS6; NRG1; ERCC6; ABI1A; GHRL
    receptor binding HMGCL; RIPK2; PARK7; SERPINE2; CADM2; ITGA1; MAG; WNT4A; HSPA1A; ABL1
    receptor tyrosine kinase binding CPNE3; NRG1; SOCS5; ANGPT4; DNAJA3; NCK1; PLCG1; MYOC; TRP53; LRP4
    transcription cofactor activity MSX2; ANKRA2; POU2AF1; ZNF710; TRIP13; TFB2M; RFXANK; KAT2B; CREB1; CALCOCO1
    transmembrane receptor protein tyrosine kinase activator activity EFNA5; NRG3; GREM1; EGF; NRG1; ANGPT4

    NRG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRG1.

    EGFR; dnaE; q7cgr6_yerpe; CDC5L

    McCormick, ME; Collins, C; et al. Platelet Endothelial Cell Adhesion Molecule-1 Mediates Endothelial-Cardiomyocyte Communication and Regulates Cardiac Function. JOURNAL OF THE AMERICAN HEART ASSOCIATION 4:-(2015).
    Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).

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