Native Human a-Macroglobulin


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Native Human a-Macroglobulin

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Cat.No. : a-Macroglobulin-535H
Product Overview : Native Human a-Macroglobulin was purified from human plasma.
Description : alpha-2-Macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis.
Source : human plasma
Species : Human
Form : Lyophilized from 0.02 M Tris, 0.13 M glycine, pH 8.0, and 0.08 M trehalose
Bio-activity : This product is a preparation of the intact protein with proteolytic inhibitory activity. One mg of protein will inhibit a minimum of 10 mg of trypsin with an activity of 10,000 BAEE units/mg protein.
Molecular Mass : mol wt ~720 kDa (four glycoprotein subunits)
Purity : ≥98% (SDS-PAGE)
Applications : Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin sequence, the macroglobulin rearranges and traps the protease.
Notes : Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.
Storage : The lyophilized powder is stable for at least 2 years when stored at -20 °C.

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