A2M
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Official Full Name
alpha-2-macroglobulin
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Background
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008] -
Synonyms
A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;
- Involved Pathway
- Protein Function
- Interacting Protein
- A2M Related Articles
- A2M Related Research Area
A2M involved in several pathways and played different roles in them. We selected most pathways A2M participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with A2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C4A;F8;C1RA;CD59;CR1;SERPINA1;CFH;GM5077;F11 |
A2M has several biochemical functions, for example, calcium-dependent protein binding, enzyme binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A2M itself. We selected most functions A2M had, and list some proteins which have the same functions with A2M. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent protein binding | A2M;SYN1;STX2;S100B;CASQ2;SEC31A;CHP;TSG101;MASP1 |
| enzyme binding | AKT1;PTPLAD2;KALRN;CASP2;HIST1H2AI;RCOR2;CNTNAP2;SRC;EIF2AK3 |
| growth factor binding | GHR;LIFR;SDCBP;A2M;HTRA1B;OSMR;KDR;FLT4;BMPR2 |
| interleukin-1 binding | HAX1;TRIM16;A2M |
| interleukin-8 binding | A2M;CXCR2;CXCR1 |
| protease binding | ITGB1;CD70;C10orf2;PINK1;IL1R1;BDKRB2;DVL3;POLG;COMP |
| protein binding | ACTN1;COG8;FGF1;EIF4ENIF1;RPL11;DDRGK1;UHRF1;EN1;TDRD9 |
| receptor binding | FGF8A;FGF18B;CADM3;WNT2BA;CADM2A;GAS6;ECH1;PVRL3;NPY |
| serine-type endopeptidase inhibitor activity | SERPINH1A;SERPINB11;PTI;SPINT2;WFDC1;WFDC12;SERPINH1B;SERPINA3C;ITIH3 |
| tumor necrosis factor binding | TNFRSF1A;A2M;Tnfrsf26 |
A2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A2M here. Most of them are supplied by our site. Hope this information will be useful for your research of A2M.
SMAP; ADAMTS12; ADAMTS7; IL1B; KLK3; MMP2; IL10; SPACA3; IFIT3; NUDT21; MGEA5; CDK2AP2; RPP14; APOE; TTR; TK1; APP; CYP2C8; UMPS
- Q&As
- Reviews
Q&As (6)
Ask a questionIt play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.
Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.
The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.
Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.
A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.
A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.
Customer Reviews (3)
Write a reviewIt can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value. -
Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients. -
The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly. -
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