a2m
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  • Official Full Name
  • alpha-2-macroglobulin
  • Background
  • Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
  • Synonyms
  • A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;
Cat.#:A2M-242HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human A2M Protein, MYC/DDK-tagged
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Cat.#:A2M-003HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human A2M Protein, GST-tagged
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Cat.#:A2M-4176HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameHuman Alpha-2-Macroglobulin
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Cat.#:A2M-5731HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human A2M protein, His-tagged
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Cat.#:A2M-6857HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human A2M, His tagged
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Cat.#:A2m-5732MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse A2m protein, His-tagged
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Cat.#:A2M-377RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat A2M Protein
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Cat.#:A2m-5734RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat A2m protein, His-tagged
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Cat.#:A2m-5735RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat A2m protein, His-tagged
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Cat.#:a2M-3326PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig a2M, His-tagged
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Cat.#:A2M-5733PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig A2M protein, His-tagged
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Cat.#:A2M-27054THTag:
Source (Host):Species:Human
Product nameNative Human A2M
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Cat.#:A2M-8019HTag:N/A
Source (Host):Human SerumSpecies:Human
Product nameNative Human Serum Alpha 2 MacroGlobulin
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Cat.#:A2m-367MTag:N/A
Source (Host):Mouse serumSpecies:Mouse
Product nameNative Mouse Alpha-2-Macroglobulin
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Cat.#:A2m-8030MTag:N/A
Source (Host):Mouse serumSpecies:Mouse
Product nameNative Mouse A2m
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Cat.#:A2m-695RTag:N/A
Source (Host):Rat SerumSpecies:Rat
Product nameNative Rat Alpha-2-Macroglobulin
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Cat.#:A2m-8020RTag:N/A
Source (Host):Rat SerumSpecies:Rat
Product nameNative Rat Serum Alpha-2-MacroGlobulin
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Cat.#:A2M-593HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human A2M cell lysate
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Cat.#:A2M-1HTag:
Source (Host):Species:Human
Product nameHuman A2M Reference Standard
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Cat.#:A2m-71RTag:N/A
Source (Host):Species:Rat
Product nameRat A2M Protein Reference Standard
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Involved Pathway

A2M involved in several pathways and played different roles in them. We selected most pathways A2M participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with A2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
LOC100514666; C1QA; C9; F13A1; CPB2; C4BP; F13B; F2; Hc; CD59

Protein Function

A2M has several biochemical functions, for example, calcium-dependent protein binding, enzyme binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A2M itself. We selected most functions A2M had, and list some proteins which have the same functions with A2M. You can find most of the proteins on our site.
Function
Related Protein
Function calcium-dependent protein binding
Related Protein STX2; ANXA11; SYT1; DDX5; SELP; VPS37B; TSG101; CALM2; RAC3; CHP
Function enzyme binding
Related Protein WWOX; DVL1; CALU; CTNNB1; CCDC99; DIS3L; TARBP2; TAF10; RFC5; NOP14
Function growth factor binding
Related Protein SDCBP; NKD2; IGFBP2B; ERBB3; RHBDF1; ACVR2B; NRP1; FLT4; GHR; IGFBP2A
Function interleukin-1 binding
Related Protein A2M; HAX1; TRIM16
Function interleukin-8 binding
Related Protein CXCR1; CXCR2; A2M
Function protease binding
Related Protein FAP; DPP4; FLOT2; F3; Serpina1b; PYCARD; LDLR; C10orf2; MBP; TIMP1
Function protein binding
Related Protein ADORA1; SLIRP; PCK2; FBL; ZNF643; NAA10; CCDC25; WSB1; SAFB2; FAM161A
Function receptor binding
Related Protein HRG; TAC1; ITGA1; HLA-B; BAAT; IAPP; IL1RAPL1; HSD17B4; ARPP19A; TNFSF8
Function serine-type endopeptidase inhibitor activity
Related Protein MUG1; ITIH6; SERPINA1L; SERPINB6; SERPING1; SERPINA3C; SPOCK1; WFIKKN2; COL6A3; SERPINE1
Function tumor necrosis factor binding
Related Protein TNFRSF1A; A2M; Tnfrsf26

Interacting Protein

A2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A2M here. Most of them are supplied by our site. Hope this information will be useful for your research of A2M.
SMAP; ADAMTS12; ADAMTS7; IL1B; KLK3; MMP2; IL10; SPACA3; IFIT3; NUDT21; MGEA5; CDK2AP2; RPP14; APOE; TTR; TK1; APP; CYP2C8; UMPS

A2M Related Articles

Lee, JH; Cho, CH; et al. Semi-quantitative Measurement of a Specific Glycoform Using a DNA-tagged Antibody and Lectin Affinity Chromatography for Glyco-biomarker Development. MOLECULAR & CELLULAR PROTEOMICS 14:782-795(2015).
Vissers, LELM; Bonetti, M; et al. Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:317-324(2015).