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Official Full Name alpha-2-macroglobulin
Background Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
Synonyms A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;
    • Species :
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Serum
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Mouse Serum
    • Rat serum
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human A2M-003H Recombinant Human A2M Protein, GST-tagged Wheat Germ GST
    Human A2M-1H Human A2M Reference Standard N/A
    Human A2M-242H Recombinant Human A2M Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human A2M-27054TH Native Human A2M N/A
    Human A2M-4176H Human Alpha-2-Macroglobulin Human N/A
    Human A2M-499H Recombinant Human A2M Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human A2M-5731H Recombinant Human A2M protein, His-tagged E.coli His
    Human A2M-593HCL Recombinant Human A2M cell lysate Insect Cell N/A
    Human A2M-6857H Recombinant Human A2M, His tagged Insect Cell His
    Human A2M-8019H Native Human Serum Alpha 2 MacroGlobulin Human Serum N/A
    Mouse A2m-367M Native Mouse Alpha-2-Macroglobulin Mouse Serum N/A
    Mouse A2m-5732M Recombinant Mouse A2m protein, His-tagged E.coli His
    Mouse A2m-8030M Native Mouse A2m Mouse Serum N/A
    Mouse CPBT-27113MM Mouse Anti-Mouse A2M Polyclonal Antibody Mouse N/A
    Rat A2M-377R Recombinant Rat A2M Protein Mammalian Cell His
    Rat A2m-5734R Recombinant Rat A2m protein, His-tagged E.coli His
    Rat A2m-5735R Recombinant Rat A2m protein, His-tagged E.coli His
    Rat A2m-695R Native Rat Alpha-2-Macroglobulin Rat serum N/A
    Rat A2m-71R Rat A2M Protein Reference Standard N/A
    Rat A2m-8020R Native Rat Serum Alpha-2-MacroGlobulin Rat Serum N/A
    Pig a2M-3326P Recombinant Pig a2M, His-tagged E.coli His
    Pig A2M-5733P Recombinant Pig A2M protein, His-tagged E.coli His

    A2M involved in several pathways and played different roles in them. We selected most pathways A2M participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with A2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades CD46; TFPI; PROS1; A2M; SERPING1; F2; F8; C9; C4BPA; F12

    A2M has several biochemical functions, for example, calcium-dependent protein binding, enzyme binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A2M itself. We selected most functions A2M had, and list some proteins which have the same functions with A2M. You can find most of the proteins on our site.

    Function Related Protein
    calcium-dependent protein binding MBL1; S100P; ANXA11; STX2; RAC3; ANXA7; CPNE3; ANXA2; VAMP2; CD209A
    enzyme binding PPP1R3B; KDM1A; KMT2E; GBP1; RAD9A; A2M; RYR2; HDAC1; YWHAE; FAM84B
    growth factor binding HTRA1A; NKD2; ERBB3; OSMR; NRP2; BMPR2; RPL37; ACVR2A; FGFBP2; A2M
    interleukin-1 binding TRIM16; HAX1; A2M
    interleukin-8 binding CXCR1; CXCR2; A2M
    protease binding CFLAR; SRI; FADD; MBL1; PINK1; BCL2; ITGA3; TIMP2; ADAMTSL4; SERPINA1
    protein binding NCOA5; TRIM44; FABP3; RTN1; TES; FATE1; VANGL1; PRPF19; SPATA8; PSMA3
    receptor binding MLYCD; MTSS1; CDH5; CCL2; PTPRD; NPY; HSPA1B; ACOX2; STOML2; VTCN1
    serine-type endopeptidase inhibitor activity EPPIN; SERPINA6; APP; FURIN; ITIH6; TFPI; A2M; PAPLN; SPINK1; WFDC6B
    tumor necrosis factor binding Tnfrsf26; TNFRSF1A; A2M

    A2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A2M here. Most of them are supplied by our site. Hope this information will be useful for your research of A2M.


    Lee, JH; Cho, CH; et al. Semi-quantitative Measurement of a Specific Glycoform Using a DNA-tagged Antibody and Lectin Affinity Chromatography for Glyco-biomarker Development. MOLECULAR & CELLULAR PROTEOMICS 14:782-795(2015).
    Vissers, LELM; Bonetti, M; et al. Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:317-324(2015).

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