• Official Full Name


  • Background

    Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
  • Synonyms

    A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Transfected Stable Cell Lines
    • Native Proteins
    • Antibody
    • Species :
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Plasma
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Mouse Serum
    • Rat serum
    • Wheat Germ
    • Yeast
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Price
    Human A2M-6857H Active Recombinant Human A2M protein, His-tagged Insect Cells His
    Human A2M-003H Recombinant Human A2M Protein, GST-tagged Wheat Germ GST
    Human A2M-4176H Human Alpha-2-Macroglobulin Human N/A
    Human A2M-5731H Recombinant Human A2M protein, His-tagged E.coli His
    Human A2M-593HCL Recombinant Human A2M cell lysate Insect Cell N/A
    Human A2M-10H Recombinant Human A2M Protein (Ser24-Ala1474), N-His tagged, Biotinylated HEK293 N-His
    Human A2M-499H Recombinant Human A2M Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human A2M-239H-B Recombinant Human A2M Protein Pre-coupled Magnetic Beads HEK293
    Human A2M-01H Active Native Human A2M Protein, Fast Form Human Plasma
    Human A2M-1097HFL Recombinant Full Length Human A2M Protein, C-Flag-tagged Mammalian cells Flag
    Human A2M-1H Active Human A2M Reference Standard N/A
    Human A2M-13H Recombinant Human A2M Protein, N-His-tagged HEK293 His
    Human A2M-239H Recombinant Human A2M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse A2m-5732M Recombinant Mouse A2m protein, His-tagged E.coli His
    Mouse A2m-367M Native Mouse Alpha-2-Macroglobulin Mouse Serum N/A
    Mouse A2m-02M Recombinant Mouse A2m Protein, His-tagged E.coli N-His
    Mouse CPBT-27113MM Mouse Anti-Mouse A2M Polyclonal Antibody Mouse N/A
    Rat A2m-5734R Recombinant Rat A2m protein, His-tagged E.coli His
    Rat A2M-377R Recombinant Rat A2M Protein Mammalian Cell His
    Rat A2m-5735R Recombinant Rat A2m protein, His-tagged E.coli His
    Rat A2m-5335R Recombinant Rat A2m protein, His-tagged Yeast His
    Rat A2m-71R Rat A2M Protein Reference Standard N/A
    Rat A2M-32R Recombinant Rat A2M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat A2M-32R-B Recombinant Rat A2M Protein Pre-coupled Magnetic Beads HEK293
    Rat A2m-695R Native Rat Alpha-2-Macroglobulin Rat serum N/A
    Pig a2M-3326P Recombinant Pig a2M, His-tagged E.coli His
    Pig A2M-5733P Recombinant Pig A2M protein, His-tagged E.coli His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • A2M Related Articles
    • A2M Related Research Area

    A2M involved in several pathways and played different roles in them. We selected most pathways A2M participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with A2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascadesC4A;F8;C1RA;CD59;CR1;SERPINA1;CFH;GM5077;F11

    A2M has several biochemical functions, for example, calcium-dependent protein binding, enzyme binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A2M itself. We selected most functions A2M had, and list some proteins which have the same functions with A2M. You can find most of the proteins on our site.

    Function Related Protein
    calcium-dependent protein bindingA2M;SYN1;STX2;S100B;CASQ2;SEC31A;CHP;TSG101;MASP1
    growth factor bindingGHR;LIFR;SDCBP;A2M;HTRA1B;OSMR;KDR;FLT4;BMPR2
    interleukin-1 bindingHAX1;TRIM16;A2M
    interleukin-8 bindingA2M;CXCR2;CXCR1
    protease bindingITGB1;CD70;C10orf2;PINK1;IL1R1;BDKRB2;DVL3;POLG;COMP
    protein bindingACTN1;COG8;FGF1;EIF4ENIF1;RPL11;DDRGK1;UHRF1;EN1;TDRD9
    receptor bindingFGF8A;FGF18B;CADM3;WNT2BA;CADM2A;GAS6;ECH1;PVRL3;NPY
    serine-type endopeptidase inhibitor activitySERPINH1A;SERPINB11;PTI;SPINT2;WFDC1;WFDC12;SERPINH1B;SERPINA3C;ITIH3
    tumor necrosis factor bindingTNFRSF1A;A2M;Tnfrsf26

    A2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A2M here. Most of them are supplied by our site. Hope this information will be useful for your research of A2M.


    Lee, JH; Cho, CH; et al. Semi-quantitative Measurement of a Specific Glycoform Using a DNA-tagged Antibody and Lectin Affinity Chromatography for Glyco-biomarker Development. MOLECULAR & CELLULAR PROTEOMICS 14:782-795(2015).
    Vissers, LELM; Bonetti, M; et al. Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:317-324(2015).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    What role does A2M protein play in the immune system? 12/18/2022

    It play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.

    What is the relationship between A2M protein and lung disease? 09/29/2022

    Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.

    In which organs or tissues are A2M proteins expressed high? 08/12/2021

    The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.

    How does A2M protein remove harmful proteins from the body? 10/14/2020

    Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.

    Can A2M protein be used as a potential therapeutic target for cardiovascular disease? 06/13/2020

    A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.

    In which neurological diseases are A2M proteins studied? 10/30/2019

    A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.

    Customer Reviews (3)

    Write a review

      It can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value. -


        Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients. -


          The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly. -

          Ask a Question for All A2M Products

          Required fields are marked with *

          My Review for All A2M Products

          Required fields are marked with *


          Stay Updated on the
          Latest Bioscience Trends

          Copyright © 2023 Creative BioMart. All Rights Reserved.

          Terms and Conditions        Privacy Policy