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A2M

  • Official Full Name

    alpha-2-macroglobulin

  • Overview

    Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
  • Synonyms

    A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Native Proteins
  • Antibody
  • Human
  • Mouse
  • Pig
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Plasma
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Mouse Serum
  • Rat serum
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human A2M-6857H Active Recombinant Human A2M protein, His-tagged Insect Cells His Met1-Ala1474
Human A2M-01H Active Native Human A2M Protein, Fast Form Human Plasma
Human A2M-003H Recombinant Human A2M Protein, GST-tagged Wheat Germ GST
Human A2M-5731H Recombinant Human A2M protein, His-tagged E.coli His Ser616~Val856 (Accession # P01023)
Human A2M-4176H Human Alpha-2-Macroglobulin Human N/A
Human A2M-593HCL Recombinant Human A2M cell lysate Insect Cell N/A
Human A2M-10H Recombinant Human A2M Protein (Ser24-Ala1474), N-His tagged, Biotinylated HEK293 N-His Ser24-Ala1474
Human A2M-499H Recombinant Human A2M Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human A2M-239H-B Recombinant Human A2M Protein Pre-coupled Magnetic Beads HEK293
Human A2M-1H Active Human A2M Reference Standard N/A
Human A2M-2504H Recombinant Human A2M protein(1161-1250 aa), C-His-tagged E.coli C-His 1161-1250 aa
Human A2M-1097HFL Recombinant Full Length Human A2M Protein, C-Flag-tagged Mammalian cells Flag
Human A2M-13H Recombinant Human A2M Protein, N-His-tagged HEK293 His
Human A2M-239H Recombinant Human A2M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse A2m-5732M Recombinant Mouse A2m protein, His-tagged E.coli His Asn157~Pro389
Mouse A2m-367M Native Mouse Alpha-2-Macroglobulin Mouse Serum N/A
Mouse A2m-02M Recombinant Mouse A2m Protein, His-tagged E.coli N-His Ser1022-Ala1495
Mouse CPBT-27113MM Mouse Anti-Mouse A2M Polyclonal Antibody Mouse N/A
Rat A2m-5734R Recombinant Rat A2m protein, His-tagged E.coli His Arg216~Phe437 (Accession # P06238)
Rat A2M-377R Recombinant Rat A2M Protein Mammalian Cell His
Rat A2m-5735R Recombinant Rat A2m protein, His-tagged E.coli His Val574~Pro734 (Accession # P06238)
Rat A2m-5335R Recombinant Rat A2m protein, His-tagged Yeast His 620-750aa
Rat A2m-71R Rat A2M Protein Reference Standard N/A
Rat A2M-32R Recombinant Rat A2M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat A2M-32R-B Recombinant Rat A2M Protein Pre-coupled Magnetic Beads HEK293
Rat A2m-695R Native Rat Alpha-2-Macroglobulin Rat serum N/A
Pig a2M-3326P Recombinant Pig a2M, His-tagged E.coli His 1477
Pig A2M-5733P Recombinant Pig A2M protein, His-tagged E.coli His Lys1097~Cys1357 (Accession # F1SLX2)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

A2M involved in several pathways and played different roles in them. We selected most pathways A2M participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with A2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesSERPINA1E;C3;C1R;CD59;CR1L;F11;F13A1;C8G;CPB2

A2M has several biochemical functions, for example, calcium-dependent protein binding, enzyme binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A2M itself. We selected most functions A2M had, and list some proteins which have the same functions with A2M. You can find most of the proteins on our site.

Function Related Protein
calcium-dependent protein bindingRBM22;SYN1;ANXA6;ANXA4;CASQ2;MASP1;CPNE3;ANXA2;A2M
enzyme bindingAPOA5;GSTM2;SCNM1-PS;HDAC2;MAT2B;YWHAB;LGALS9;ZNHIT6;UGT1A6A
growth factor bindingOSMR;REG3B;ACVR2B;TEK;FGFBP2;ACVR2A;IL6ST;LIFR;A2M
interleukin-1 bindingHAX1;TRIM16;A2M
interleukin-8 bindingCXCR2;A2M;CXCR1
protease bindingF3;CSTA;MBP;SERPINB9;BCL2;SERPINB3;INS2;ITGB1;TNFRSF10A
protein bindingIcosl;MRPL27;EIF2B2;FANCC;RBM5;RNF183;SET;LHFPL5;HARS2
receptor bindingFZD8;LRP6;SCP2;HTT;LEPROT;FGF12B;BMP2;TNFSF13;PLA2G1B
serine-type endopeptidase inhibitor activityHRG;SERPINH2;KAL1;SPINK6;SERPINA10;PZP;SERPINB13;WFDC6B;SERPINB5
tumor necrosis factor bindingA2M;TNFRSF1A;Tnfrsf26

A2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A2M here. Most of them are supplied by our site. Hope this information will be useful for your research of A2M.

SMAP; ADAMTS12; ADAMTS7; IL1B; KLK3; MMP2; IL10; SPACA3; IFIT3; NUDT21; MGEA5; CDK2AP2; RPP14; APOE; TTR; TK1; APP; CYP2C8; UMPS

Research Area

Related articles

Lee, JH; Cho, CH; et al. Semi-quantitative Measurement of a Specific Glycoform Using a DNA-tagged Antibody and Lectin Affinity Chromatography for Glyco-biomarker Development. MOLECULAR & CELLULAR PROTEOMICS 14:782-795(2015).
Vissers, LELM; Bonetti, M; et al. Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:317-324(2015).
  • Q&As
  • Reviews

Q&As (6)

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What role does A2M protein play in the immune system? 12/18/2022

It play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.

What is the relationship between A2M protein and lung disease? 09/29/2022

Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.

In which organs or tissues are A2M proteins expressed high? 08/12/2021

The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.

How does A2M protein remove harmful proteins from the body? 10/14/2020

Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.

Can A2M protein be used as a potential therapeutic target for cardiovascular disease? 06/13/2020

A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.

In which neurological diseases are A2M proteins studied? 10/30/2019

A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.

Customer Reviews (3)

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Reviews
04/19/2022

    It can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value.

    05/23/2020

      Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients.

      03/09/2020

        The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly.

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