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A4GALT

Official Full Name

Alpha 1,4-Galactosyltransferase
Overview

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.
Synonyms

A4GALT; alpha 1,4-galactosyltransferase; P1; PK; Gb3S; P(k); A14GALT; A4GALT1; lactosylceramide 4-alpha-galactosyltransferase; GB3 synthase; alpha4Gal-T1; CD77 synthase; P1/Pk synthase; P(k) antigen synthase; P blood group (P one antigen); globotriaosylceramide synthase; alpha-1,4-N-acetylglucosaminyltransferase; UDP-galactose: beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase; NP_059132.1; EC 2.4.1.228;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	A4GALT-9187H	Recombinant Human A4GALT protein, GST-tagged	Wheat Germ	GST	1 a.a. - 353 a.a.	Inquiry
Human	A4GALT-9186H	Recombinant Human A4GALT, GST-tagged	E.coli	GST	41-353a.a.	$319 / 25μg
Human	A4GALT-005H	Recombinant Human A4GALT Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	A4GALT-9163HCL	Recombinant Human A4GALT 293 Cell Lysate	HEK293	Non		Inquiry
Human	A4GALT-483H	Recombinant Human A4GALT Protein, His-tagged	E.coli	His	Gly44~Leu353	Inquiry
Human	A4GALT-574HF	Recombinant Full Length Human A4GALT Protein, GST-tagged	In Vitro Cell Free System	GST	353 amino acids	Inquiry
Mouse	A4galt-484M	Recombinant Mouse A4galt Protein, His-tagged	E.coli	His	Thr94~Ile270	Inquiry
Rat	A4GALT-379R	Recombinant Rat A4GALT Protein	Mammalian Cell	His		Inquiry
Rat	A4GALT-34R	Recombinant Rat A4GALT Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	A4GALT-34R-B	Recombinant Rat A4GALT Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	A4galt-485R	Recombinant Rat A4galt Protein, His-tagged	E.coli	His	Cys142~Thr357	Inquiry
Chicken	A4GALT-5510C	Recombinant Chicken A4GALT	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

A4GALT involved in several pathways and played different roles in them. We selected most pathways A4GALT participated on our site, such as Glycosphingolipid biosynthesis - globo series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with A4GALT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycosphingolipid biosynthesis - globo series	HEXB;ST3GAL2;NAGA;A4GALT;FUT1;FUT9;ST3GAL1;FUT9A;GBGT1
Metabolic pathways	DGAT1;RABGNT1;POLR3C;GDA;POLR1A;BHMT;CECR1A;mt-Atp8;HK3

A4GALT has several biochemical functions, for example, galactosyltransferase activity, lactosylceramide 4-alpha-galactosyltransferase activity, toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A4GALT itself. We selected most functions A4GALT had, and list some proteins which have the same functions with A4GALT. You can find most of the proteins on our site.

Function	Related Protein
galactosyltransferase activity	DPY19L4;B4GALT1;POC1BL;PIGB;B4GALT4;GTDC2;B3GNT6;C1GALT1;B3GNT5
lactosylceramide 4-alpha-galactosyltransferase activity
toxic substance binding	Alb;H2-AB1;GUCY2C;CHRNA7;AZU1;ASS1;PHAX;EPHX2;NEFH

A4GALT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A4GALT here. Most of them are supplied by our site. Hope this information will be useful for your research of A4GALT.

Dlg4; rab40c

Research Area

Lai, YJ; Wu, WY; et al. A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P-1/P-2 blood groups. TRANSFUSION 54:3222-3231(2014).

Westman, JS; Hellberg, A; et al. Large deletions involving the regulatory upstream regions of A4GALT give rise to principally novel P1PK-null alleles. TRANSFUSION 54:1831-1835(2014).