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  • Official Full Name

    alpha-2-macroglobulin-like 1

  • Overview

    This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several;proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease;paraneoplastic pemphigus (PNP; PMID: 20805888). Alternative splicing results in multiple transcript variants.
  • Synonyms

    A2ML1; alpha-2-macroglobulin-like 1; C3 and PZP like, alpha 2 macroglobulin domain containing 9 , CPAMD9; alpha-2-macroglobulin-like protein 1; FLJ25179; CPAMD9; A2ML 1; Alpha 2 macroglobulin like 1; Alpha 2 macroglobulin like protein 1; C3 and PZP like alpha 2 macroglobulin domain containing protein 9; DKFZp686C1729; DKFZp686D2011; DKFZp686G1812; DKFZp686L1821; DKFZp686O1010; FLJ16045; FLJ39129; FLJ41597; FLJ41598; FLJ41607; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human A2ML1-827H Active Recombinant Human A2ML1 Protein, His-tagged HEK293 His Glu18-Glu1454
Human A2ML1-5676H Recombinant Human A2ML1 protein, His & T7-tagged E.coli His/T7 Gln1119~Thr1348 (Accession # A8K2U0)
Human a2ML1-3328H Recombinant Human a2ML1 E.coli N/A
Human A2ML1-3327H Recombinant Human A2ML1, His-tagged E.Coli or Yeast His 1454
Human A2ML1-2105HCL Recombinant Human A2ML1 cell lysate N/A
Human A2ML1-1627H Recombinant Human A2ML1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human A2ML1-742HF Recombinant Full Length Human A2ML1 Protein, GST-tagged In Vitro Cell Free System GST 158 amino acids
Human A2ML1-1833H Recombinant Human A2ML1 protein, GST-tagged E.coli GST 1375-1454 aa
Human A2ML1-240H Recombinant Human A2ML1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human A2ML1-1318HFL Recombinant Full Length Human A2ML1 Protein, C-Flag-tagged Mammalian cells Flag
Human A2ML1-240H-B Recombinant Human A2ML1 Protein Pre-coupled Magnetic Beads HEK293
Human A2ML1-0043H Recombinant Human A2ML1 Protein (Gln1119-Thr1348), N-His-tagged E.coli N-His Gln1119-Thr1348
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

A2ML1 involved in several pathways and played different roles in them. We selected most pathways A2ML1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with A2ML1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

A2ML1 has several biochemical functions, for example, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by A2ML1 itself. We selected most functions A2ML1 had, and list some proteins which have the same functions with A2ML1. You can find most of the proteins on our site.

Function Related Protein
peptidase inhibitor activitySPINK6;WFDC13;WFDC18;EPPIN;WFDC6B;SSPO;Serpina1b;WFDC15B;SPINT4
serine-type endopeptidase inhibitor activitySERPINA11;HRG;APPB;SERPINA3C;PAPLN;SERPINB1L2;A2ML1;SERPINB7;SPINK4

A2ML1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A2ML1 here. Most of them are supplied by our site. Hope this information will be useful for your research of A2ML1.


Research Area

Related articles

Poot, AM; Diercks, GFH; et al. Laboratory diagnosis of paraneoplastic pemphigus. BRITISH JOURNAL OF DERMATOLOGY 169:1016-1024(2013).
Numata, S; Teye, K; et al. Anti-Alpha-2-Macroglobulin-Like-1 Autoantibodies Are Detected Frequently and May Be Pathogenic in Paraneoplastic Pemphigus. JOURNAL OF INVESTIGATIVE DERMATOLOGY 133:1785-1793(2013).
Schepens, I; Jaunin, F; et al. The Protease Inhibitor Alpha-2-Macroglobuline-Like-1 Is the p170 Antigen Recognized by Paraneoplastic Pemphigus Autoantibodies in Human. PLOS ONE 5:-(2010).
Galliano, MF; Toulza, E; et al. Binding of alpha 2ML1 to the Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) Reveals a New Role for LRP1 in the Human Epidermis. PLOS ONE 3:-(2008).
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