a-Macroglobulin
-
Official Full Name
a-Macroglobulin
-
Synonyms
α2-M; a-Macroglobulin;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | a-Macroglobulin-535H | Active Native Human a-Macroglobulin | human plasma | Non |
a-Macroglobulin involved in several pathways and played different roles in them. We selected most pathways a-Macroglobulin participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with a-Macroglobulin were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|
a-Macroglobulin has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by a-Macroglobulin itself. We selected most functions a-Macroglobulin had, and list some proteins which have the same functions with a-Macroglobulin. You can find most of the proteins on our site.
Function | Related Protein |
---|
a-Macroglobulin has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with a-Macroglobulin here. Most of them are supplied by our site. Hope this information will be useful for your research of a-Macroglobulin.
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewMinimal sample consumption for precious samples.
Easy adaptation to high-throughput formats for large-scale experiments.
Accurate determination of protein stability under different conditions.
Q&As (10)
Ask a questionAlpha-Macroglobulin interacts with various extracellular matrix components, including collagens, elastin, and glycosaminoglycans, influencing tissue remodeling, cell adhesion, and matrix homeostasis in different physiological and pathological contexts.
Targeting alpha-Macroglobulin may provide therapeutic opportunities to modulate protease activity in specific pathological conditions, either by enhancing its inhibitory function or developing small molecules that mimic its protease-trapping activity.
Alpha-Macroglobulin levels or activity may serve as a diagnostic marker for conditions associated with abnormal protease activity, such as cancer, cardiovascular diseases, or neurodegenerative disorders.
Alpha-Macroglobulin interacts with cell surface receptors, such as low-density lipoprotein receptor-related protein 1 (LRP1), to mediate endocytosis and downstream signaling events that regulate cell behavior and inflammation.
The structural features of alpha-Macroglobulin, such as its bait region and thioester domain, play critical roles in recognizing and trapping proteases, allowing for their subsequent clearance or degradation.
Alpha-Macroglobulin interacts with a wide range of proteases, including serine proteases, metalloproteases, and cysteine proteases, targeting specific cleavage sites within their catalytic domains.
Alpha-Macroglobulin is involved in modulating inflammation and immune responses by regulating the activity of proteases that are implicated in these processes, thereby influencing the activation and function of immune cells.
Alpha-Macroglobulin acts as a protease inhibitor by undergoing conformational changes upon protease binding, leading to the formation of a covalent complex that sequesters the protease and prevents its activity.
Alpha-Macroglobulin clearance occurs through receptor-mediated endocytosis, with LRP1 playing a major role in its internalization and subsequent trafficking to lysosomes for degradation.
Genetic variations or mutations in alpha-Macroglobulin can affect its protease inhibitory capacity, leading to altered protease regulation and potential associations with diseases such as familial hypercholesterolemia or Alzheimer's disease.
Ask a Question for All a-Macroglobulin Products
Required fields are marked with *
My Review for All a-Macroglobulin Products
Required fields are marked with *