A4GNT
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Official Full Name
alpha-1,4-N-acetylglucosaminyltransferase -
Overview
This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. -
Synonyms
A4GNT;alpha-1,4-N-acetylglucosaminyltransferase;alpha4GnT;MGC149493
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| A4GNT-2462H | Recombinant Human A4GNT protein, His-tagged | E.coli | Human | His | 76-340 aa | |
| A4GNT-16H | Recombinant Human A4GNT, His-tagged | HEK293 | Human | His | 26-340 a.a. |
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| A4GNT-17H | Recombinant Human A4GNT, His-DHFR-tagged | E.coli | Human | DHFR&His |
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| A4GNT-9162HCL | Recombinant Human A4GNT 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
A4GNT involved in several pathways and played different roles in them. We selected most pathways A4GNT participated on our site, such as Metabolism of proteins,O-linked glycosylation,O-linked glycosylation of mucins, which may be useful for your reference. Also, other proteins which involved in the same pathway with A4GNT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | ANKRD28,THSD7A,EIF5A2,TFG,ADAMTSL4,NAT8,IGFBP5,ASNA1,MUC5AC,MPDU1B |
| heparan sulfate biosynthesis | MAPK1IP1L,HS3ST4 |
| heparan sulfate biosynthesis (late stages) | HS3ST4 |
| O-linked glycosylation | ADAMTS8,SPON1B,ADAMTSL5,ADAMTS18,KCNA6,ADAMTS5,GALNTL2,SSPO,ADAMTS4,ST6GALNAC2 |
| Post-translational protein modification | GALNT13,MUCL1,RING1,NEU4,PHC2,MUC13,SMC5,TMED2,TRAPPC4,TRAPPC6B |
| O-linked glycosylation of mucins | B3GNT6,MUC13,MUC4,B3GNT8,MUC1,MUC21,B3GNT2A,MUC5AC,GALNT6,ST6GALNAC2 |
Protein Function
A4GNT has several biochemical functions, for example, acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by A4GNT itself. We selected most functions A4GNT had, and list some proteins which have the same functions with A4GNT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylglucosaminyltransferase activity | GALNT18A,XYLT2,EXT1,C3orf39,B3GNT9-PS,OGT,DPY19L1,B3GALNT2,LARGE,POC1BL |
Interacting Protein
A4GNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A4GNT here. Most of them are supplied by our site. Hope this information will be useful for your research of A4GNT.
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References
- Karasawa, F; Shiota, A; et al. Essential role of gastric gland mucin in preventing gastric cancer in mice. JOURNAL OF CLINICAL INVESTIGATION 122:923-934(2012).
- Nakayama, J; Katsuyama, T; et al. Recent progress in paradoxical concanavalin A staining. ACTA HISTOCHEMICA ET CYTOCHEMICA 33:153-157(2000).
