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A1CF

Official Full Name

APOBEC1 complementation factor
Background

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.
Synonyms

A1CF; APOBEC1 complementation factor; ACF; ACF64; ACF65; APOBEC1CF; ASP; apo-B RNA editing protein; APOBEC-1 stimulating protein; apobec-1 complementation factor (ACF) (ASP); RP11-564C4.2; MGC163391;

Type:
Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species :
Human
Mouse
Rat

Source :
E.coli
HEK293
HEK293T
Mammalian Cell

Tag :
His
His (Fc)
Avi
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	A1CF-641H	Recombinant Human A1CF Protein, His-tagged	E.coli	His	$269.00 / 10ug $1,998.00 / 1mg
Human	A1CF-9165HCL	Recombinant Human A1CF 293 Cell Lysate	HEK293	N/A	Inquiry
Human	A1CF-1197H	Recombinant Human A1CF Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Human	A1CF-0375H	Recombinant Human A1CF Protein (Gly389-Arg587), His-tagged	E.coli	His	$269.00 / 10ug $1,998.00 / 1mg
Human	A1CF-3507H	Recombinant Human A1CF protein, His-tagged	E.coli	His	$319.00 / 25ug
Human	A1CF-0376H	Recombinant Human A1CF Protein (Gly389-Arg587), N-His-tagged	E.coli	N-His	$269.00 / 10ug $1,998.00 / 1mg
Mouse	A1cf-1446M	Recombinant Mouse A1cf Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	A1cf-01M	Recombinant Mouse A1cf Protein, His-tagged	E.coli	N-His	$269.00 / 10ug $1,998.00 / 1mg
Rat	A1CF-376R	Recombinant Rat A1CF Protein	Mammalian Cell	His	Inquiry
Rat	A1CF-31R	Recombinant Rat A1CF Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Rat	A1CF-31R-B	Recombinant Rat A1CF Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
A1CF Related Articles

A1CF involved in several pathways and played different roles in them. We selected most pathways A1CF participated on our site, such as Formation of the Editosome, Gene Expression, mRNA Editing, which may be useful for your reference. Also, other proteins which involved in the same pathway with A1CF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Formation of the Editosome	A1CF;APOBEC1
Gene Expression	ZNF486;ZNF498;MED8;DARS;TNPO1;CCNT2B;ZNF37A;ZNF143A;ZNF615
mRNA Editing	ADARB1A;A1CF;ADARB1;APOBEC1
mRNA Editing: C to U Conversion	A1CF;APOBEC1

A1CF has several biochemical functions, for example, RNA binding, NOT double-stranded RNA binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A1CF itself. We selected most functions A1CF had, and list some proteins which have the same functions with A1CF. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	EIF2S1B;RPL21;EIF3B;NABP1;NOM1;RPL24;TLR13;NHP2L1B;DDX19B
NOT double-stranded RNA binding
nucleotide binding	ATP1A1A.5;HNRNPA1A;UBE2D2A;GNA11A;CAMKK1B;SETD1B;ABCG2C;PRKG1A;FGFR1A
protein binding	SMOC1;PAX3;PSMC4;POP7;DDX42;G3BP2;PPP4R4;NOP58;SH3BP2
single-stranded RNA binding	PIWIL1;RBMX;HNRNPF;POLR2G;DHX58;IFIH1;SNRPC;TLR7;AGO3

A1CF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A1CF here. Most of them are supplied by our site. Hope this information will be useful for your research of A1CF.

REL; TRAF1; FHL3; uvrB; ssrna_au

Nonaka, T; Doi, T; et al. Carboxy-terminal domain of AID required for its mRNA complex formation in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106:2747-2751(2009).

Conticello, SG; et al. The AID/APOBEC family of nucleic acid mutators. GENOME BIOLOGY 9:-(2008).