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Recombinant Human PAX6

Cat.No. : PAX6-29055TH
Product Overview : Recombinant fragment corresponding to amino acids 1-209 of Human PAX6; 209 amino acids, Predicted MWt 22.8 kDa.
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Description : This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peters anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene.
Protein length : 209 amino acids
Molecular Weight : 22.800kDa
Source : E. coli
Tissue specificity : Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS (8.1mM Dibasic monohydrogen sodium phosphate, 500mM Sodium chloride, 2.7mM Potassium chloride, 1.5mM Monobasic dihydrogen potassium phosphate, pH 7.4)
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the paired homeobox family.Contains 1 homeobox DNA-binding domain.Contains 1 paired domain.
Gene Name : PAX6 paired box 6 [ Homo sapiens ]
Official Symbol : PAX6
Synonyms : PAX6; paired box 6; AN2, paired box gene 6 (aniridia, keratitis); paired box protein Pax-6; AN; aniridia; keratitis; D11S812E; WAGR;
Gene ID : 5080
mRNA Refseq : NM_000280
Protein Refseq : NP_000271
MIM : 607108
Uniprot ID : P26367
Chromosome Location : 11p13
Pathway : CDC42 signaling events, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Insulin Synthesis and Processing, organism-specific biosystem;
Function : DNA binding; R-SMAD binding; RNA polymerase II core promoter sequence-specific DNA binding; protein binding; sequence-specific DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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