PAX7
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Official Full Name
paired box 7
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Overview
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] -
Synonyms
PAX7; paired box 7; HUP1; RMS2; PAX7B; paired box protein Pax-7; paired domain gene 7; paired box homeotic gene 7; PAX7 transcriptional factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- His
- T7
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PAX7-132H | Recombinant Human PAX7 protein, T7/His-tagged | E.coli | His&T7 |
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| Human | PAX7-29057TH | Recombinant Human PAX7 | Wheat Germ | Non | 111 amino acids |
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| Human | PAX7-3414HCL | Recombinant Human PAX7 293 Cell Lysate | HEK293 | Non |
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| Human | PAX7-3413HCL | Recombinant Human PAX7 293 Cell Lysate | HEK293 | Non |
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| Human | PAX7-4801H | Recombinant Human PAX7 Protein (Arg355-Gln467), N-His tagged | E.coli | His | Arg355-Gln467 |
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| Human | PAX7-2924H | Recombinant Human PAX7 protein, His-tagged | E.coli | His | 330-378 aa | |
| Chicken | PAX7-6622C | Recombinant Chicken PAX7 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PAX7 involved in several pathways and played different roles in them. We selected most pathways PAX7 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | RELA;ID2;KLF3;IL6;BCL6;FOXO1;PPARG;H3F3C;RUNX1 |
PAX7 has several biochemical functions, for example, sequence-specific DNA binding, transcription factor activity, RNA polymerase II core promoter sequence-specific, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX7 itself. We selected most functions PAX7 had, and list some proteins which have the same functions with PAX7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | FOXN2;HOXC6B;IRX6A;ELF2B;RAX2;NKX2;HOXD4;NR1H3;MAFF |
| transcription factor activity, RNA polymerase II core promoter sequence-specific | MEF2C;TFAP2B;PAX7;HEY1;HEY2;SMAD3;NKX3;HEYL;MAX |
| transcription factor activity, sequence-specific DNA binding | SLC30A9;EOMESA;HNF1BB;ATF4B2;TCF3;TBX3A;CSRNP3;GBX2;NFAT5A |
PAX7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX7.
Dlg4; FYN; SRC; AKR1B1; NCK1; CRK
Research Area
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Q&As (7)
Ask a questionAltered PAX7 activity can contribute to the development of muscular dystrophies and other muscle disorders.
PAX7 works in conjunction with other proteins to regulate muscle cell growth and differentiation.
Targeting PAX7 offers potential treatment strategies for muscle degeneration and repair in muscular diseases.
It plays a key role in maintaining muscle stem cells, ensuring their ability to regenerate and repair muscle tissue.
Genetic mutations in PAX7 can lead to impaired muscle development and various muscular pathologies.
PAX7 is a transcription factor crucial for the development and differentiation of muscle cells.
PAX7 is involved in muscle regeneration, activating genes necessary for muscle repair after injury.
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