PAX3
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Official Full Name
paired box 3
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Overview
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically;contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development.;Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and;alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead;gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding;isoforms with different C-termini. -
Synonyms
PAX3; paired box 3; paired box gene 3 (Waardenburg syndrome 1) , Waardenburg syndrome 1 , WS1; paired box protein Pax-3; HUP2; paired domain gene 3; paired domain gene HuP2; paired box homeotic gene 3; WS1; WS3; CDHS; MGC120381; MGC120382; MGC120383; MGC;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PAX3 involved in several pathways and played different roles in them. We selected most pathways PAX3 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | RARA;FLT3;HIST1H3F;RUNX2;HDAC2;HIST2H3C2;KDM6A;PTK2;BCL2A1 |
PAX3 has several biochemical functions, for example, HMG box domain binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX3 itself. We selected most functions PAX3 had, and list some proteins which have the same functions with PAX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| HMG box domain binding | HOXC4;EGR2;MEOX1;HOXA3;GATA3;OLIG2;DLX5;ALX4;POU3F3 |
| chromatin binding | L3MBTL1;CBX5;CBX7;SP140L;MEIS3;SMARCE1;PELP1;EBF2;EGR2 |
| protein binding | BLOC1S1;SEC22B;RND2;SLC22A6;NDFIP2;YWHAZ;PCDH18;MEF2A;PKMYT1 |
| sequence-specific DNA binding | ATF6B;TCF7L1A;TRP53;NFYBB;HSFY1;IRX6A;TEFA;HOXC3A;MAFGA |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | MEIS1;MITF;MEF2C;HNF4A;PROX1;MYOD1;RFX3;CEBPB;CEBPA |
| transcription factor activity, sequence-specific DNA binding | SOX1;KDM5B;FOXA;ZFP36L1;ZNF383;NKX6-2;HOXB4A;TBX19;ZFP191 |
PAX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX3.
POU3F2; MEOX2; SOX10; ABL1; FYN; SRC; NCK1; GRB2
Research Area
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