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PAX4

  • Official Full Name

    paired box 4

  • Overview

    This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]
  • Synonyms

    PAX4; paired box 4; KPD; MODY9; paired box protein Pax-4; paired box gene 4; paired domain gene 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • Fc
  • Avi
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PAX4-29532TH Recombinant Human PAX4 Wheat Germ Non 97 amino acids
Human PAX4-392H Recombinant Human PAX4 Protein, His-tagged E.coli His
Human PAX4-3417HCL Recombinant Human PAX4 293 Cell Lysate HEK293 Non
Mouse PAX4-12393M Recombinant Mouse PAX4 Protein Mammalian Cell His
Mouse PAX4-6518M Recombinant Mouse PAX4 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse PAX4-6518M-B Recombinant Mouse PAX4 Protein Pre-coupled Magnetic Beads HEK293
Rat PAX4-4283R Recombinant Rat PAX4 Protein Mammalian Cell His
Rat PAX4-3945R Recombinant Rat PAX4 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rat PAX4-3945R-B Recombinant Rat PAX4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PAX4-8070Z Recombinant Zebrafish PAX4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PAX4 involved in several pathways and played different roles in them. We selected most pathways PAX4 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Maturity onset diabetes of the youngONECUT1;MAFA;FOXA2;NR5A2;IAPP;HNF1A;PDX1;NEUROD1;SLC2A2

PAX4 has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX4 itself. We selected most functions PAX4 had, and list some proteins which have the same functions with PAX4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingMB21D1;NUSAP1;BLM;PAX2B;ZFP354B;IRX7;GLYR1;HLFB;ZBTB32
RNA polymerase II distal enhancer sequence-specific DNA bindingPOU4F1;NFKB1;NR2F6;H3F3B;NFE2L2;MIXL1;H2AFZ;NFATC1;PROP1
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific bindingPROP1;ARX;PAX4;MSC;GZF1;ZBTB16;BACH2;BACH1

PAX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX4.

Research Area

Related articles

Bonnavion, R; Jaafar, R; et al. Both PAX4 and MAFA Are Expressed in a Substantial Proportion of Normal Human Pancreatic Alpha Cells and Deregulated in Patients with Type 2 Diabetes. PLOS ONE 8:-(2013).
Lorenzo, PI; Moreno, CMJ; et al. Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors. HISTOCHEMISTRY AND CELL BIOLOGY 136:595-607(2011).
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